Globin digest, acidic protease hydrolysate, inhibits dietary hypertriglyceridemia and Val-Val-Tyr-Pro, one of its constituents, possesses most superior effect

Kagawa, Keiichiro; Matsutaka, Hisako; Fukuhama, Chizuko; Watanabe, Yukiko; Fujino, Hiroaki

doi:10.1016/0024-3205(96)00156-7

Cited by 70 publications

(62 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that these mechanisms differ from that of Alaska pollack protein. On the other hand, globin digests are considered to act through an oligopeptide (Val-ValTyr-Pro), which inhibits pancreatic lipase activity, to prevent fat digestion and fatty acid absorption in the intestine (13,14). In the case of Alaska pollack protein, it is possible that peptides similar to those in globin digests are released either during the preparation of the test diets or during digestion in the intestinal tract.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alaska Pollack Protein Prevents the Accumulation of Visceral Fat in Rats Fed a High Fat Diet

Oishi

Dohmoto

2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryIn the first study (Study 1), 4-wk-old Sprague-Dawley (SD) rats were fed high fat diets containing casein, Alaska pollack, yellowfin tuna, or chicken as the protein source for 28 d. The purpose of this study was to compare the effect of Alaska pollack protein with other animal proteins (casein, yellowfin tuna, and chicken) on the prevention of visceral fat accumulation. We found that Alaska pollack protein was a more potent inhibitor of visceral fat accumulation than the other proteins ( p Ͻ 0.05). In the second study (Study 2), we determined the quantity of Alaska pollack protein needed to have an effect. To test this, 4-wk-old SD rats were fed diets containing different percentages of Alaska pollack proteins (0, 3, 10, 30 or 100%) to replace casein as the protein source for 28 d. The diets with 30 or 100% Alaska pollack protein as the protein source prevented visceral fat accumulation and elevated plasma adiponectin levels. Based on these findings, an inhibitory effect on the accumulation of visceral fats can be achieved by consuming a diet in which 30% or more of the total protein content comes from Alaska pollack.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Several neutraceuticals such as catechin (12) and globin digests (13,14), that prevent accumulation of visceral fat have been developed. These have mechanisms of action that vary widely and are not yet fully understood.…”

Section: Discussionmentioning

confidence: 99%

Alaska Pollack Protein Prevents the Accumulation of Visceral Fat in Rats Fed a High Fat Diet

Oishi

Dohmoto

2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…Concerning the action of low-molecular peptide, the oligopeptide produced by the digestion of globin has an anti-hypertriglyceridemic effect. 30) Soybean phytochemicals such as isoflavone and saponin have been demonstrated to exert hypocholesterolemic effect. [31][32][33][34] Since these components might be contained in intact soybean protein and its peptides, 18) it is necessary to investigate these activities in the future.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Soybean Peptides on Hepatic Production of Ketone Bodies and Secretion of Triglyceride by Perfused Rat Liver

Tamaru

Kurayama

Sakono

et al. 2007

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

“…Lifestyle education during primary care visits to emphasize the need for an appropriate diet and exercise routine is an important basic strategy to treat childhood obesity [7,8,9,10]; however, the success of these efforts is often hampered by the limited contact the child has with their primary care facility [8,9,10]. Thus, there is interest in using drugs or functional foods and beverages that are easily taken at home and could help prevent or reduce childhood obesity [11,12,13,21,22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Obesity occurs most often as a consequence of excessive caloric intake resulting in increased storage of triglycerides in adipose tissue [20]; therefore, pharmacological inhibition of triglyceride (TG) synthesis or absorption is a potential therapeutic strategy to reduce obesity [11,12,13,22,23]. Previously, globin digest (GD), an oligopeptide mixture derived from edible globin proteins, was developed as a functional food or beverage and has been shown to be effective at reducing hyperlipidemia and to have hepatoprotective effects in humans and other mammals [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Globin Digest as a Functional Beverage for the Treatment of Childhood Obesity

Tokuhara¹,

Cho²,

Shintaku³

2017

JFNR

View full text Add to dashboard Cite

Background and aims:Childhood obesity is a serious health concern in many countries in the world.In addition to lifestyle education, functional foods or beverages may be useful for preventing and treating obesity. Here we evaluated the effectiveness and safety of a globin digest (GD) functional beverage for the treatment of childhood obesity. Methods: Twenty-eight obese Japanese children (median age, 12.4 years; range, 6.0-17.3 years; 18 males) were randomly assigned to receive orally either placebo beverage (n = 14) or GD beverage containing 6 mg of the amino acid residue Val-Val-Tyr-Pro (n = 14) within 1 h of eating dinner daily for 3 months. Changes in body weight, body mass index percentile, and percentage overweight were based on Japanese age-, sex-, and heightspecific body-weight standards. The prevalence of adverse events was also evaluated. Results: The changes in body weight, body mass index percentile, or percentage overweight were not significantly different between the two groups at 3 months or at 6 months after the start of GD intake. No adverse events were reported in any of the subjects. Conclusions: Although the effectiveness of GD beverages for the treatment of childhood obesity needs further evaluation, the GD beverage used in the present study was safe and had good compliance in obese Japanese children.

show abstract

Globin digest, acidic protease hydrolysate, inhibits dietary hypertriglyceridemia and Val-Val-Tyr-Pro, one of its constituents, possesses most superior effect

Cited by 70 publications

References 10 publications

Alaska Pollack Protein Prevents the Accumulation of Visceral Fat in Rats Fed a High Fat Diet

Alaska Pollack Protein Prevents the Accumulation of Visceral Fat in Rats Fed a High Fat Diet

Effects of Dietary Soybean Peptides on Hepatic Production of Ketone Bodies and Secretion of Triglyceride by Perfused Rat Liver

Efficacy and Safety of Globin Digest as a Functional Beverage for the Treatment of Childhood Obesity

Contact Info

Product

Resources

About