GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists

Deo, S. V. S.; Sharma, Jyoti; Kumar, Sunil

doi:10.1245/s10434-022-12151-6

Cited by 250 publications

(155 citation statements)

References 17 publications

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“…466 prognosis related genes were reserved for further analysis, and then the 466 survival related genes were analyzed by lasso and multivariate Cox (multicox), and finally 8 candidate genes were included in this angiogenesis-related signature. ARG_scores (risk socre) were calculated using the following method: ARG_ Score = gene expression ( 1 ) × Corresponding coefficient ( 1 ) + gene expression ( 2 ) × Corresponding coefficient ( 2 ) + gene expression [n] × Corresponding coefficient [n]. The patients were categorized into high-risk and low-risk groups based on the median score.…”

Section: Methodsmentioning

confidence: 99%

Section: Construction Of the Angiogenesis-related Prognostic Arg_scorementioning

confidence: 99%

“…Colorectal cancer (CRC) is one of the most common malignant tumors. According to the latest global cancer statistics, CRC has the third highest incidence (10.0%) and the second highest mortality rate (9.4%) in the world ( 1 ). Moreover, the incidence of CRC is trending younger, with an annual increase of 2% in incidence and 1.3% in mortality among people under 50 years of age ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma

Cui

Liu²,

Wang³

et al. 2022

Front. Immunol.

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BackgroundColorectal adenocarcinoma (COAD) is one of the most common malignancies and angiogenesis is vital to the development of cancer. Here, we explored the roles of angiogenesis-related genes (ARGs) that affect the prognosis of COAD and constructed risk models to assess patient prognosis, immune characteristics, and treatment outcomes.MethodsWe comprehensively characterized the transcriptional and genetic modifications of 48 ARGs in COAD and evaluated the expression patterns. We identified two ARG subgroups using the consensus clustering algorithm. Based on the differentially expressed genes (DEGs) of two ARG subtypes, we calculated risk score, namely ARG_scores, and calssified COAD patients into different risk groups. To investigate the expression of ARG_score-related genes, qRT-PCR was performed. Subsequently, we mapped the nomogram to visually and accurately describe the value of the application of ARG_score. Finally, the correlation between ARG_score and clinical features, immune infiltration along with drug sensitivity were explored.ResultsWe identified two ARG related subgroups and there were great differences in overall survival (OS) and tumor microenvironment. Then, we created an ARG_score for predicting overall survival based on eight DEGs and confirmed its reliable predictive power in COAD patients, with higher ARG_score associated with worse prognosis. Furthermore, eight ARG_score-related genes expression was investigated by qRT-PCR. To make the ARG_score clinically feasible, we created a highly reliable nomogram. We also found a higher proportion of microsatellite instability-high (MSI-H) and higher tumor mutational burden (TMB) in the high-risk group. In addition, ARG_score was notably correlated with cancer stem cell indices and drug sensitivity.ConclusionThis scoring model has potential clinical application value in the prognosis, immune microenvironment and therapeutic drug sensitivity of COAD, which provides new insights for personalized treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Construction Of the Angiogenesis-related Prognostic Arg_scorementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma

Cui

Liu²,

Wang³

et al. 2022

Front. Immunol.

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“…As GLOBOCAN 2020 reports, there were 19.3 million new cancer cases diagnosed in 2020, and almost 10.0 million people died due to cancer. GLOBOCAN predicts that the number of cancer cases will increase to 28.4 million by 2040 [2,3]. Female breast cancer is the most common type of cancer (2.26 million cases), with a significant disease burden and high mortality rates [4].…”

Section: Introductionmentioning

confidence: 99%

Antifungal, antiradical, anti-inflammatory and antineoplastic activities of essential oils of some medicinal plants of the Annonaceae family of Chad and Cameroon

Bakarnga-Via¹,

DJIMADOUM²,

Fokou³

et al. 2022

JPP

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Yeasts infections, cancer and other diseases associated with free radical generation and inflammation are currently a critical public health issue that needs innovative control measures. In order to search for solutions, this study was designed to assess the antifungal, radical scavenging, anti-inflammatory, and antineoplastic activities of essential oils from four Annonaceae plants (Monodora myristica, Xylopia aethiopica, and Xylopia parviflora) collected in Chad and Cameroon. Essential oils were extracted by hydrodistillation. The antifungal activity of the oils was determined using the microdilution method; and their antiradical activity was determined using the DPPH free radical scavenging assay. The anti-inflammatory activity was assessed using the inhibitory effect of oils against the 5-lipoxigenase. Flow cytometry was used to assess the effect of essential oils on cell cycle. The essential oils of X. aethiopica, X. parviflora, and M. myristica inhibited the growth of Candida albicans ATCC24433, Candida parapsilosis ATCC22019, and Cryptococcus neoformans IP95026 with MIC values ranging from 5 to 10 mg/mL. Essential oils of X. aethiopica, X. parviflora, and M. myristica showed free radical scavenging potential with SC50 values between 8.9 and 11.74 g/L. The oils samples at 100 μg/mL from both origins significantly inhibited cancer cell (MCF-7) and normal epithelial cells of the eye (ARPE-19) growth, with a notable cell cycle arrest at phases G0/G1 and S at 72h respectively. According to the findings of this study, essential oils from Annonaceae plants contain bioactive secondary metabolites that have the potential to inhibit pathogenic yeasts, free radicals, inflammatory and cancer cells. Further research is needed to confirm these findings and formalize their eventual application to control the targeted affections.

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“…Along with the patrolling of tissue integrity, iNKT cells actively participate in the immune surveillance against malignant transformation and tumor progression, including human colorectal cancer (CRC) 10 . CRC is the third most prevalent cancer worldwide and the second leading cause of cancer-related death 11 . Microbiota-elicited inflammation is an important contributor to CRC pathogenesis regardless of pre-cancer inflammatory history 12 .…”

Section: Introductionmentioning

confidence: 99%

Tumor infiltrating iNKT cells sustain neutrophil pro-tumorigenic functions influencing disease progression in human colorectal cancer

Lattanzi

Strati

Díaz‐Basabe

et al. 2022

Preprint

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AbstractiNKT cells account for a relevant fraction of effector T-cells in the intestine. Although iNKT cells are cytotoxic lymphocytes, their role in colorectal cancer (CRC) remains controversial. From the analysis of colonic LPMCs of human and murine CRC specimens we report that tumor-infiltrating iNKT cells are characterized by an IL17/GM-CSF pro-tumorigenic phenotype, while maintaining cytotoxic properties in the adjacent non-tumoral tissue. Exposure of iNKT cells to the tumor-associated pathobiontFusobacterium nucleatumblunted their cytotoxic capability and enhanced iNKT cell-mediated neutrophils chemotaxis, which upregulated PMN-MDSC gene signatures and functions. Importantly,in vivostimulation of iNKT cells with αGalCer restored their anti-tumorigenic functions. Survival analyses demonstrated that human CRC co-infiltration by iNKT cells and tumor-associated neutrophils correlates with negative outcomes.Our results reveal a functional plasticity of human intestinal iNKT cells with pro- and anti-tumorigenic activities in CRC, suggesting an iNKT pivotal role in shaping the cancer developmental trajectory.

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GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists

Cited by 250 publications

References 17 publications

Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma

Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma

Antifungal, antiradical, anti-inflammatory and antineoplastic activities of essential oils of some medicinal plants of the Annonaceae family of Chad and Cameroon

Tumor infiltrating iNKT cells sustain neutrophil pro-tumorigenic functions influencing disease progression in human colorectal cancer

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