Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies

Vetvik, Katja; Sonerud, Tonje; Lindeberg, Mona M.; Lüders, Torben; Størkson, Ragnhild H.; Jónsdóttir, Kristín; Frengen, Eirik; Pietiläinen, Kirsi H.; Bukholm, Ida Rashida Khan

doi:10.1016/j.metabol.2014.02.001

Cited by 26 publications

(29 citation statements)

References 46 publications

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“…Full-length adiponectin can be posttranslationally modified to produce a globular domain with potent metabolic consequence. The relative ratio between globular adiponectin and full-length adiponectin was considerably higher in tumor samples than in the surrounding colorectal mucosa from the same individuals [117]. These results suggest that CRC tumors synthesize adiponectin locally and then posttranslationally modified it to produce globular adiponectin to higher levels than in the surrounding healthy colorectal mucosa.…”

Section: Colorectal Cancer Obesity and Adiponectinmentioning

confidence: 79%

“…Full-length adiponectin was found at lower levels in tumors than in the surrounding colorectal mucosa. In contrast the total expression of adiponectin transcript was higher in tumors [117]. Full-length adiponectin can be posttranslationally modified to produce a globular domain with potent metabolic consequence.…”

Section: Colorectal Cancer Obesity and Adiponectinmentioning

confidence: 86%

“…Adiponectin is expressed by both colorectal tumors and the surrounding colorectal mucosa [117]. Full-length adiponectin was found at lower levels in tumors than in the surrounding colorectal mucosa.…”

Section: Colorectal Cancer Obesity and Adiponectinmentioning

confidence: 94%

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Role of adiponectin in obesity related gastrointestinal carcinogenesis

Nagaraju

Aliya

Alese

2015

Cytokine & Growth Factor Reviews

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Section: Colorectal Cancer Obesity and Adiponectinmentioning

confidence: 79%

Section: Colorectal Cancer Obesity and Adiponectinmentioning

confidence: 86%

See 1 more Smart Citation

Role of adiponectin in obesity related gastrointestinal carcinogenesis

Nagaraju

Aliya

Alese

2015

Cytokine & Growth Factor Reviews

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“…Adiponectin receptor has two isoforms: the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). Adiponectin after binding to its receptors can activate several intracellular pathways, including AMPK/mTOR, mitogen-activated protein kinases (MAPK), and phosphoinositide 3-kinase (PI3K)/AKT [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

AdipoRon: a possible drug for colorectal cancer prevention?

Malih

Najafi

2015

Tumor Biol.

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Colorectal cancer (CRC) is in the third place of the most common cancers. Certain risk factors can increase the development of CRC, including diet and inheritance. Several studies have shown that there is a potential link between obesity and CRC. Adipose tissue is known to be a largest endocrine organ in the body, with the ability to produce various cytokines including adiponectin. Two types of adiponectin receptor, AdipoR1 and AdipoR2, have been detected in various cancer tissues such as CRC. There is mounting evidence that AdipoR1 signaling occurs mainly through 5′ AMP-activated protein kinase (AMPK) and adiponectin inhibits colorectal cancer cell growth via activation of AMPK, thereby suppression of the mammalian target of rapamycin (mTOR) pathway. Thus, adiponectin replacement-based therapies may represent a novel approach in CRC cell growth inhibition in early stages. AdipoRon is an adiponectin-like synthetic small molecule that activated both adiponectin receptors 1 and 2. We hypothesize that AdipoRon has antiproliferative effects of adiponectin and may suppress the CRC cell growth. With clarification of this drug's role in CRC, it can be used as chemoprevention in patients at risk of developing the disease.

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“…Adiponektinin antikanserojen aktivitesi vardır ve obez bireylerde adiponektin plazma konsantrasyonu belirgin şekilde azalır. Yapılan araştırmalarda Adipor1 ve Adipor2'nin adenokarsinomlarda normal dokulara kıyasla fazla miktarda eksprese edildiği, aynı zamanda bu hastalarda adiponektin serum seviyesinin de artış gös-terdiği [13], ayrıca serum adiponektin seviyesinin ve adiponektin reseptörlerinin ekspresyon düzeylerinin kolorektal kanser gelişimi ve evresiyle ilişkili olabileceği de gösterilmiştir [1,[11][12][13][14][15]. Bu nedenlerle adiponektin son zamanlarda obezite ile ilişkili kolorektal karsinogenezis gelişimi mekanizmasında rol alabileceği düşünülen popüler bir moleküldür.…”

Section: Introductionunclassified