Globus pallidus internus activity during simultaneous bilateral microelectrode recordings in status dystonicus

Levi, Vincenzo; Franzini, Andrea; Rinaldo, Sara; Coelli, Stefania; Bianchi, Anna Maria; Nardocci, Nardo; Eleopra, Roberto; Zorzi, Giovanna

doi:10.1007/s00701-020-04618-w

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…In addition to the results derived from this study, increasing evidence shows that plastic changes occur in the contralesional and ipsilesional cortex simultaneously [67][68][69]. Neural responses recorded from multi-areas were required to understand the mechanism(s) underlying the integration between the contralesional and ipsilesional cortex [70,71]. Moreover, further experimental paradigms, such as introducing task-specific obstacle-induced perturbations and unanticipated gait perturbations [72,73], are required to explore the neural mechanisms underling steady walking after SCI.…”

Section: Discussionmentioning

confidence: 90%

Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles

Wang

et al. 2021

Brain Sciences

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Recent studies have shown that motor recovery following spinal cord injury (SCI) is task-specific. However, most consequential conclusions about locomotor functional recovery from SCI have been derived from quadrupedal locomotion paradigms. In this study, two monkeys were trained to perform a bipedal walking task, mimicking human walking, before and after T8 spinal cord hemisection. Importantly, there is no pharmacological therapy with nerve growth factor for monkeys after SCI; thus, in this study, the changes that occurred in the brain were spontaneous. The impairment of locomotion on the ipsilateral side was more severe than that on the contralateral side. We used information theory to analyze single-cell activity from the left primary motor cortex (M1), and results show that neuronal populations in the unilateral primary motor cortex gradually conveyed more information about the bilateral hindlimb muscle activities during the training of bipedal walking after SCI. We further demonstrated that, after SCI, progressively expanded information from the neuronal population reconstructed more accurate control of muscle activity. These results suggest that, after SCI, the unilateral primary motor cortex could gradually regain control of bilateral coordination and motor recovery and in turn enhance the performance of brain–machine interfaces.

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Section: Discussionmentioning

confidence: 90%

Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles

Wang

et al. 2021

Brain Sciences

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“…Multiple MERs studies compared the activity of GPi neurons either across different diseases or before, during, and after functional microstimulation [24][25][26][27][28][29][30][31], neglecting or restricting the topographical analysis along the pre-planned trajectory axis. These studies identified high-frequency cells whose discharge rate (up to 150 Hz) may feature movement disorders.…”

Section: Introductionmentioning

confidence: 99%

Mapping the electrophysiological structure of dystonic Globus Pallidus pars interna through intraoperative microelectrode recordings

Kaymak

Vissani

Rinaldo

et al. 2022

Preprint

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Objective. The Globus Pallidus pars interna (GPi) is one of the main targets for Deep Brain Stimulation (DBS) therapies for dystonia and other movement disorders. Still, a complete picture of the spiking dynamics of the nucleus is far from being achieved. Microelectrode recordings (MER) provide a unique brain window opportunity to shed light on GPi organization, which might support intraoperative DBS target localization, as previously done for the Subthalamic nucleus (STN). Approach. Here we propose a novel procedure to analyze explorative MERs from DBS implants in dystonic patients. The procedure identifies the neural activity markers discriminating neurons in the GPi from those in the neighbouring structures, as well as the markers discriminating neurons located in different regions within the GPi. Main results. The identification of the borders of the GPi based on neural markers was a difficult task, due to internal inhomogeneities in GPi firing dynamics. However, the procedure was able to exploit these inhomogeneities to characterize the internal electrophysiological structure of the GPi. In particular, we found a reliable dorsolateral gradient in firing activity and regularity. Significance. Overall, we characterized the spatial distribution of neural activity markers in the dystonic GPi, paving the way for the use of these markers for DBS target localization. The procedure we developed to achieve this result could be easily extended to MER performed for other disorders and in other areas.

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The changing face of reported status dystonicus – A systematic review

Lumsden

Cif

Capuano

et al. 2023

Parkinsonism & Related Disorders

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Globus pallidus internus activity during simultaneous bilateral microelectrode recordings in status dystonicus

Cited by 4 publications

References 17 publications

Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles

Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles

Mapping the electrophysiological structure of dystonic Globus Pallidus pars interna through intraoperative microelectrode recordings

The changing face of reported status dystonicus – A systematic review

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