This study aims to obtain teachers’ perspectives, practices, and challenges in English for specific purposes in non-English major students. The researchers distributed some questionnaires as the instrument to the English Teacher Forum. There were seven respondents from some universities; University of Muhammadiyah Makassar, STIMIK Widya Pratama, University of Muhammadiyah Lamongan, University of Mataram, University of Muhammadiyah Magelang, University of Muhammadiyah Banjarmasin, Banyuwangi State Polytechnic, and Indonesian Aviation School (STTKD) Yogyakarta. The questions items focused on obtaining the respondents’ characteristics including the length of teaching ESP, the gender, their major in teaching ESP, etc. Also, it tried to explore the ESP teachers’ perspectives, practices, and the challenges during teaching ESP. The findings stated all respondents have been teaching in other major than English; Economics, Engineering, Health, and Tourism. All respondents agreed to that ESP is an essential part in their learners’ academic and/or professional life, taught by collaboration among English teachers, major teachers, and practitioners with the qualifications such as knowledge in a specific topic and certain sciences, qualify in English to teach the learners in their field of study, English teachers who have experience in the field related with the material taught, and the length of time to encounter the subject or competence certification on the related subject.