2017
DOI: 10.1007/s00424-017-2053-4
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Glomerular and tubular effects of nitric oxide (NO) are regulated by angiotensin II (Ang II) in an age-dependent manner through activation of both angiotensin receptors (AT1Rs and AT2Rs) in conscious lambs

Abstract: Renin-angiotensin (RAS) and nitric oxide (NO) systems and the balance and interaction between them are considered of primary importance in maintaining fluid and electrolyte homeostasis. It has been suggested that the effects of NO may be modulated at least in part by the angiotensin (Ang) II, yet the roles of angiotensin receptor type 1 (AT1R) and type 2 (AT2R) are not well understood. Even though both Ang II and NO are elevated at birth and during the newborn period, their contribution to the adaptation of th… Show more

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Cited by 3 publications
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“…AT2R is distributed in renal vessels, glomeruli, juxtaglomerular apparatus, tubules, arteries, and renal capsules [ 26 , 42 ], and this receptor is involved in the regulation of renal hemodynamic and tubular functions [ 43 ]. The stimulation of AT2R in the afferent arterioles has a vasodilatory effect [ 44 ] and in the renal tubules causes sodium excretion and pressure natriuresis [ 45 ].…”
Section: Introductionmentioning
confidence: 99%
“…AT2R is distributed in renal vessels, glomeruli, juxtaglomerular apparatus, tubules, arteries, and renal capsules [ 26 , 42 ], and this receptor is involved in the regulation of renal hemodynamic and tubular functions [ 43 ]. The stimulation of AT2R in the afferent arterioles has a vasodilatory effect [ 44 ] and in the renal tubules causes sodium excretion and pressure natriuresis [ 45 ].…”
Section: Introductionmentioning
confidence: 99%