Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis

Urushihara, Maki; Kubo, Shoji; Kuhara, Takashi; Takahashi, Toshiaki; Kuroda, Yasuhiro

doi:10.1093/ndt/17.7.1189

Cited by 72 publications

(78 citation statements)

References 23 publications

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“…Single nucleotide polymorphisms in MMP-14 confer risk for developing focal seg- 3, 9, 24, 112, 113). Increased glomerular MMP-9 was found in lupus nephritis, IgA nephropathy, Henoch-Schoenlein Purpura (HSP), and postinfectious glomerulonephritis (134). MMP-7 is induced in renal tubular epithelium of the kidneys in FSGS and IgA nephropathy (45).…”

Section: Mmps In Renal Pathologymentioning

confidence: 99%

Matrix metalloproteinases in kidney homeostasis and diseases

Tan

Liu

2012

American Journal of Physiology-Renal Physiology

221

219

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Section: Mmps In Renal Pathologymentioning

confidence: 99%

Matrix metalloproteinases in kidney homeostasis and diseases

Tan

Liu

2012

American Journal of Physiology-Renal Physiology

221

219

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“…Although induction of MMP-3 and MMP-9 are well documented in glomerular disease, 31,32 expression of MMP-12 in normal or diseased glomeruli has not been documented, with the exception of autoimmune glomerulonephritis, where the MMP-12 expression is due to infiltrating macrophages. 18 Kidneys from wild-type and 7-week-old Alport mice were immunostained using antibodies specific for MMP-12.…”

Section: Mmp-12 Expression Is Markedly Induced In Glomeruli From Alpomentioning

confidence: 99%

Role for Macrophage Metalloelastase in Glomerular Basement Membrane Damage Associated with Alport Syndrome

Rao

Meehan

Delimont

et al. 2006

The American Journal of Pathology

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“…Expression of MMP-9 within glomeruli was found in IgA nephropathy, Schoenlein-Henoch purpura, and poststreptococcal glomerulonephritis [13].…”

Section: Introductionmentioning

confidence: 99%

Urinary MMP-9/NGAL Ratio as a Potential Marker of FSGS in Nephrotic Children

et al. 2013

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Abstract. BACKGROUND:The study was undertaken to develop a potential new markers for distinguishing minimal change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS) in children. We hypothesized that matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin (MMP-9/NGAL) is a better marker of focal sclerosis in the glomerulus then matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) and matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 MMP2/TIMP-2. METHODS: The present study used a sample of 36 children and adolescents subdivided into two groups: I -20 children with MCNS, subjected to examination twice: A -in relapse of nephrotic syndrome, before treatment and B -after regression of proteinuria; II -16 children with FSGS. MMPs and TIMPs and NGAL levels were measured in the urine using ELISA kit. MMP-9/TIMP-1, MMP-2/TIMP-2 and MMP-9/NGAL ratios were calculated. RESULTS: Median NGAL/cr. was significantly higher in MCNS and FSGS patients when compared to healthy controls. Both, NGAL and MMP-9 urinary levels were significantly elevated in FSGS subjects, as compared with control subjects. Contrary to FSGS children, in MCNS group, before treatment only NGAL/cr., but not MMP-9/cr. was increased. Urinary concentrations of NGAL and MMP-9 were highly associated with each other (NGAL/cr. vs. MMP-9/cr., r = 0.485, p < 0.01). Median urine MMP-9/NGAL ratio in FSGS patients was significantly higher than in patients with MCNS. We also found that significant increase in MMP-9/NGAL was associated with FSGS [odds ratio (OR) -9.0; confidence interval (CI) 1.97-41.07]. CONCLUSION: MMP-9/NGAL ratio may serve as differentiation marker between MCNS and FSGS in nephrotic children.

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Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis

Abstract: These results strongly suggest that MMP-9 plays an important role in abnormal mesangial proliferative changes in human GN.

Cited by 72 publications

References 23 publications

Matrix metalloproteinases in kidney homeostasis and diseases

Matrix metalloproteinases in kidney homeostasis and diseases

Role for Macrophage Metalloelastase in Glomerular Basement Membrane Damage Associated with Alport Syndrome

Urinary MMP-9/NGAL Ratio as a Potential Marker of FSGS in Nephrotic Children

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