Glomerular Filtration

Renkin, Eugene M.; Robinson, Roscoe R.

doi:10.1056/nejm197404042901408

Cited by 74 publications

(65 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…cm2) by assuming frGC = (1rAA + 7rEA)/2. Our estimate of k for the rat glomerular capillary is thus even higher than previously reported (3,20,21), and is some 50 times greater than that recently found for capillaries in rat skeletal muscle (22).…”

Section: Discussioncontrasting

confidence: 71%

Dynamics of Glomerular Ultrafiltration in the Rat. IV. DETERMINATION OF THE ULTRAFILTRATION COEFFICIENT

Deen¹,

Troy²,

Robertson³

et al. 1973

J. Clin. Invest.

195

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 71%

Dynamics of Glomerular Ultrafiltration in the Rat. IV. DETERMINATION OF THE ULTRAFILTRATION COEFFICIENT

Deen¹,

Troy²,

Robertson³

et al. 1973

J. Clin. Invest.

195

View full text Add to dashboard Cite

show abstract

“…The relatively constant Tmp/GFR (numerically equal to the mean plasma threshold for phosphate excretion) indicates that the limits to the phosphate transport system are similar between sheep and that the dependence of total reabsorptive capacity upon GFR may be due to grading of tubular function at varying GFRs (Renkin and Gilmore 1973). It is also possible that the changes in ion and fluid reabsorption rates from within the proximal tubule resulting from the different GFRs may alter the equilibrium tubular fluid to plasma phosphate ratio (Knox et al 1973) and hence the Tmp.…”

Section: Excretion Of Cationsmentioning

confidence: 99%

“…The mechanism(s) for this relatively high reabsorption is not yet defined. It seems unlikely that there is any marked difference in the number of nephrons per unit body size of the animals except perhaps a higher number in the rat (Rytand 1938;Renkin and Gilmore 1973). Phosphate reabsorption takes place predominantly in the proximal tubule (Knox et al 1973) and this segment comprises a substantially greater proportion of the renal tubule in herbivores than in carnivores (Sperber 1944).…”

Section: Excretion Of Cationsmentioning

confidence: 99%

Renal Response to Intravenous Phosphate Infusion in the Sheep

Fürst¹

1975

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

Renal clearance experiments were performed on six Merino ewes in which plasma phosphate concentrations were increased by the intravenous infusion of isohydric sodium phosphate. As the phosphate load to the kidney increased, the renal tubular reabsorptive capacity became saturated and a definite tubular maximum for phosphate reabsorption (Tmp) was demonstrated. The Tmp was directly related to the glomerular filtration rate and had a mean value of 333·1 ± 27·0 (S.E.M.) /lmol! min or 416· 6± 13· 5/lmol!100 ml glomerular filtrate. Calcium infused concurrently with phosphate in order to maintain plasma total calcium levels did not alter the Tmp. Ultrafilterability of calcium and phosphate in the plasma decreased with phosphate infusion and this was accentuated by an accompanying calcium infusion.The Tmp in sheep's kidney is higher than in non-ruminant animals and the implications of this are discussed.

show abstract

“…Such functional studies would seem to be of paramount importance in that much experimental and theoretical evidence exists to indicate that the passage of macromolecules across the glomerular capillary wall is influenced by a variety of factors (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). These not only include macromolecular size but also net macromolecular charge, and the hemodynamic determinants of the glomerular filtration rate of water (GFR) as well.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of the Puromycin-Induced Defects in the Transglomerular Passage of Water and Macromolecules

Bohrer¹,

Baylis²,

Robertson³

et al. 1977

J. Clin. Invest.

140

View full text Add to dashboard Cite

A B S T R A C T To investigate the mechanism(s) of increased filtration of serum proteins after glomerular injury, polydisperse samples of uncharged [ 42A were determined in these rats, together with direct measurements of the forces governing the glomerular filtration rate of water. Whole kidney and single nephron glomerular filtration rates were -40% lower in PAN-treated rats, relative to controls, due mainly to a marked reduction in the glomerular capillary ultrafiltration coefficient and, to a lesser extent, to a small reduction in glomerular plasma flow rate as well. In PAN-treated rats, as in normal controls, inulin was found to permeate the glomerular capillary wall without measurable restriction, and both D and DS were shown to be neither secreted nor reabsorbed. Fractional clearances of uncharged D were reduced after PAN administration, falling significantly for effective D radii from 22 to 38A. Utilizing a theory based on macromolecular transport through pores, these results indicate that in PAN-treated rats, effective pore radius is the same as in controls, -44A. In PAN nephrosis, however, the ratio of total pore surface area/pore length, a measure of pore density, is reduced to approximately one-third that of control, due very likely to a reduction in filtration surface area. In contrast to the results with uncharged D, fractional clearances of DS were found to increase after PAN

show abstract

Glomerular Filtration

Cited by 74 publications

References 3 publications

Dynamics of Glomerular Ultrafiltration in the Rat. IV. DETERMINATION OF THE ULTRAFILTRATION COEFFICIENT

Dynamics of Glomerular Ultrafiltration in the Rat. IV. DETERMINATION OF THE ULTRAFILTRATION COEFFICIENT

Renal Response to Intravenous Phosphate Infusion in the Sheep

Mechanisms of the Puromycin-Induced Defects in the Transglomerular Passage of Water and Macromolecules

Contact Info

Product

Resources

About