Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy X-ray absorptiometry

Taylor, Timothy P.; Wang, Wei; Shrayyef, Muhammad; Cheek, DeAnna E.; Hutchison, Florence N.; Gadegbeku, Crystal A.

doi:10.1093/ndt/gfi102

Cited by 28 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study carried out in Sweden [9] showed an improvement in the accuracy of eGFR when calculated lean mass was included in the prediction equation. None of these studies have employed the CKD-EPI equation and are limited to relatively small groups of patients or special populations [5,6,7,8,9,10,11,12]. Our study suggests that body composition may also be of importance in the general population but the effect may be of lesser magnitude than in these selected populations.…”

Section: Discussionmentioning

confidence: 78%

“…Several previously published studies on the relationship between muscle mass and measured GFR suggest that lean mass might influence eGFR when calculated using the MDRD equation [5,6,7,8,9,10,11,12]. For example, Macdonald et al [10] found that in non-diabetic CKD patients appendicular lean mass index explained an additional 10% of the variability in measured GFR after adjusting for creatinine, age and gender.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, when compared to measured GFR, the performance of both equations has been shown to be minimally affected by basic anthropometric measures such as body mass index (BMI) [3,4], suggesting that age, gender and race may be adequate surrogate markers for body composition. However, small studies in certain patient populations indicate that lean body mass should be taken into account when estimating GFR using the MDRD equation [5,6,7,8,9,10,11,12]. Thus, the failure of GFR estimating equations to adequately adjust for variations in muscle mass may lead to misdiagnosis and misclassification of CKD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between Body Composition and Glomerular Filtration Rate Estimates in the General Population

Gunnarsson

Pálsson²,

Sigurðsson³

et al. 2013

Nephron Clin Pract

View full text Add to dashboard Cite

Background: Differences in body composition may lead to imprecision in estimates of glomerular filtration rate (eGFR) derived from serum creatinine. Our aims were to examine the relationship between eGFR and anthropometric and body composition measures and handgrip strength. Methods: We analyzed data from a cross-sectional study comprising 1,630 randomly selected community-dwelling adults. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were used to calculate eGFR from IMDS-standardized serum creatinine. Body mass index and body surface area were calculated from measured height and weight. Body composition was determined by dual-energy x-ray absorptiometry, handgrip strength measured by a hand-held dynamometer. Regression analysis was used to examine the association between eGFR and other factors. Results: In women, eGFR determined by the MDRD equation was inversely associated with height (β = -0.08; p = 0.012), lean mass percentage (β = -0.06; p = 0.047) and handgrip strength (β = -0.15; p < 0.001) and eGFR calculated using the CKD-EPI equation was inversely associated with handgrip strength (β= -0.08; p = 0.001). In men, there was an inverse association between eGFR by the MDRD equation and lean mass percentage (β = -0.10; p = 0.013) and handgrip strength (β = -0.12; p = 0.022) and between eGFR by the CKD-EPI equation and lean mass percentage (β = -0.07; p = 0.018). The R² for these variables was <0.02. Conclusions: The inverse relationship between eGFR and measures of lean mass percentage and handgrip strength suggests that incorporation of these variables might improve eGFR prediction from serum creatinine in the general population. This effect appears to be small however and needs to be examined in studies that include measured GFR.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Body Composition and Glomerular Filtration Rate Estimates in the General Population

Gunnarsson

Pálsson²,

Sigurðsson³

et al. 2013

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…The MDRD Study equation might overestimate kidney function in subjects with IUGR, and a possible low-normal kidney function will be veiled, rendering the observed ORs conservative. Formulas including lean body mass could have been well suited for this research question, 30 but information for lean body mass was not available.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intrauterine Growth Restriction on Kidney Function at Young Adult Age: The Nord Trøndelag Health (HUNT 2) Study

Hallan

Euser

Irgens

et al. 2008

American Journal of Kidney Diseases

127

View full text Add to dashboard Cite

“…The applicability of these equations in Asians, who generally have a smaller body habitus and consequently, different creatinine metabolism than other ethnic groups is unclear [13][14][15][16]. In addition, the utility of the MDRD equation in individuals with normal renal function, diabetic nephropathy or who may vary in glucose tolerance status is still controversial [12,17,18].…”

Section: Introductionmentioning

confidence: 99%

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft–Gault equation in screening for impaired kidney function in Japanese Americans

Gerchman

Tong

Utzschneider

et al. 2007

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

The Cockcroft-Gault and the Modification of Diet in Renal Disease (MDRD) Study equations have not been validated in Asian Americans with varying degrees of glucose tolerance. We compared both equations to 24 hour urinary creatinine clearance, the latter as a standard measurement of glomerular filtration rate (GFR), in 398 Japanese Americans (62.1±5.8y, mean±SD) who had normal glucose tolerance (n=138), impaired glucose tolerance (n=136) and diabetes (n=124). Although both the Cockcroft-Gault (r=0.65, P<0.001) and the MDRD (r=0.74, P<0.001) equations correlated well with creatinine clearance, the latter was significantly superior (P=0.013 between r values). ROC curve analysis showed that the area under the curve (AUC) for the MDRD equation was significantly greater than for the Cockcroft-Gault equation (AUC 0.86 vs. 0.80, P=0.015) in classifying subjects as having mildly reduced GFR (<90 ml/min per 1.73 m 2 ). However, both equations overestimated the number of individuals with decreased GFR. We conclude therefore that while the MDRD equation more accurately identifies Asians who are in the early stages of kidney disease, as for other groups, a correction term appears necessary in order to reduce the number of Asian subjects being falsely diagnosed with CKD.

show abstract

Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy X-ray absorptiometry

Abstract: Although further validation is necessary, these findings suggest that total body non-invasive measurement of LM along with Scr can be used to accurately predict GFR.

Cited by 28 publications

References 16 publications

Relationship between Body Composition and Glomerular Filtration Rate Estimates in the General Population

Relationship between Body Composition and Glomerular Filtration Rate Estimates in the General Population

Effect of Intrauterine Growth Restriction on Kidney Function at Young Adult Age: The Nord Trøndelag Health (HUNT 2) Study

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft–Gault equation in screening for impaired kidney function in Japanese Americans

Contact Info

Product

Resources

About