Glomerular lesions in male rabbits treated with aluminium lactate: with special reference to microaneurysm formation

Hong, C. B.; Fredenburg, Andrea M.; Dickey, Kenneth M.; Lovell, Mark A.; Yokel, Robert A.

doi:10.1016/s0940-2993(00)80104-9

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Regarding aluminum-induced renal damage in both sex rabbits at both scarifications, there were congestion of intertubular blood vessels and glomerular capillary tufts with attenuation and necrosis of tubular epithelium particularly proximal convoluted tubules. These results are consistent with those results reported previously by Al Kahtani et al (2014) and Hong et al (2000). The glomeruli of aluminum treated female and male rabbits showed ischemic glomerular collapse and mesangiolysis like observed in a variety of glomerular diseases including thrombotic microangiopathies (e.g., preeclampsia, hemolytic uremic syndrome), toxic glomerulopathy and in renal transplantation Paueksakon et al (2002).…”

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confidence: 92%

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Saad¹,

Hassieb²,

Oda³

et al. 2018

AJVS

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Key words:aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degenerationThe present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6 th weeks and the 12 th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.

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