Glomerular Nephropathy Associated With Chronic Q Fever

Pérez‐Fontán, Miguel; Huarte, Emma; Tellez, A.; Rodríguez‐Carmona, Ana; Picazo, M; Martínez-Ara, Jorge

doi:10.1016/s0272-6386(88)80134-3

Cited by 22 publications

(10 citation statements)

References 18 publications

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“…Glomerulonephritis has been reported as a manifestation of Q fever in humans (18,29; M. Morovic, B. Dzelalija, S. Novakovic, S. Stankovic, and J. Dujella, Letter, Nephron 64:335, 1993). In animals, renal disease caused by C. burnetii is only a transient lesion as part of a disseminated C. burnetii infection (3).…”

Section: Discussionmentioning

confidence: 99%

SCID Mouse Model for Lethal Q Fever

Andoh¹,

Naganawa²,

Hotta³

et al. 2003

Infect Immun

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Q fever, a worldwide zoonosis caused by Coxiella burnetii, has many manifestations in humans. Endocarditis is the most serious complication of Q fever. Animal models are limited to acute pulmonary or hepatic disease and reproductive disorders. An appropriate experimental animal model for Q fever endocarditis does not yet exist. In this study, severe combined immunodeficient (SCID) mice infected with C. burnetii showed persistent clinical symptoms and died, whereas immunocompetent mice similarly infected became asymptomatic and survived. The SCID mice examined in this study had severe chronic lesions in their primary organs: the heart, lung, spleen, liver, and kidney. The heart lesions of the SCID mice were similar to those in humans with chronic Q fever endocarditis: they had focal calcification and expanded macrophages containing C. burnetii. The 50% lethal dose of C. burnetii in SCID mice was at least 10 8 times less than that in immunocompetent mice. The SCID mouse is highly susceptible to C. burnetii, and the immunodeficiency of the host enhances the severity of Q fever. This animal model could provide a new tool for the study of chronic Q fever and Q fever in immunodeficient hosts.

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Section: Discussionmentioning

confidence: 99%

SCID Mouse Model for Lethal Q Fever

Andoh¹,

Naganawa²,

Hotta³

et al. 2003

Infect Immun

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“…When a skin biopsy is performed, histologic examination of the specimen shows immune complex vasculitis. Renal involvement can occur, and proliferative glomerulonephritis has been reported (212,280,284), increasing the risk of renal insufficiency. Embolic manifestations occur in about 20% of patients and can involve cerebral and upper-or lower-extremity vessels.…”

Section: ͻ150 ϫ 10mentioning

confidence: 99%

Endocarditis Due to Rare and Fastidious Bacteria

2001

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The etiologic diagnosis of infective endocarditis is easily made in the presence of continuous bacteremia with gram-positive cocci. However, the blood culture may contain a bacterium rarely associated with endocarditis, such as Lactobacillus spp., Klebsiella spp., or nontoxigenic Corynebacterium, Salmonella, Gemella, Campylobacter, Aeromonas, Yersinia, Nocardia, Pasteurella, Listeria, or Erysipelothrix spp., that requires further investigation to establish the relationship with endocarditis, or the blood culture may be uninformative despite a supportive clinical evaluation. In the latter case, the etiologic agents are either fastidious extracellular or intracellular bacteria. Fastidious extracellular bacteria such as Abiotrophia, HACEK group bacteria, Clostridium, Brucella, Legionella, Mycobacterium, and Bartonella spp. need supplemented media, prolonged incubation time, and special culture conditions. Intracellular bacteria such as Coxiella burnetii cannot be isolated routinely. The two most prevalent etiologic agents of culture-negative endocarditis are C. burnetti and Bartonella spp. Their diagnosis is usually carried out serologically. A systemic pathologic examination of excised heart valves including periodic acid-Schiff (PAS) staining and molecular methods has allowed the identification of Whipple's bacillus endocarditis. Pathologic examination of the valve using special staining, such as Warthin-Starry, Gimenez, and PAS, and broad-spectrum PCR should be performed systematically when no etiologic diagnosis is evident through routine laboratory evaluation

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“…Kidney diseases associated with Q fever endocarditis are glomerular injuries. The histologic lesions include dif fuse proliferative glomerulonephritis [7,8], focal-segmen tal glomerulonephritis [6,10], and mesangiocapillary glo merulonephritis [9], The extent of initial glomerular inju ries determines the kidney prognosis. Our patient shows the insidious progression of Q fever endocarditis revealed by glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

“…However, Perez-Fontan et al [6] have described a patient with good clinical course after 10 months of treatment, but in whom proliferative injury persisted on renal biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Acute forms are asso ciated with pneumonia, hepatitis, and meningoencephali tis. Chronic forms, which are arbitrarily defined as a course longer than 3 months, are associated with endocar ditis [1], hepatitis [2], osteomyelitis [3], vascular prosthe sis infection [4], and pulmonary disease [5], Endocarditis, the most frequently reported entity, can be associated with glomerulonephritis [6][7][8][9][10] and cryoglobulinemia [11,12], We describe an uncommon case of C. burnetii endocarditis associated with cryoglobulinemia, as re vealed by focal and segmental proliferative glomerulone phritis.…”

Section: Introductionmentioning

confidence: 99%

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Prolif erative Glomerulonephritis Revealing Chronic Q Fever

Vacher-Coponat

Dussol²,

Raoult³

et al. 1996

Am J Nephrol

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We describe the case of a 69-year-old male with a year-long history of renal failure. Investigation revealed proliferative glomerulonephritis, cryoglobulinemia, and Q fever endocarditis. Renal tissue examination for the presence of Coxiella burnetii was positive. The patient was treated by doxycycline and chloroquine; his clinical status, renal failure, and chronic Q fever have dramatically improved.

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Glomerular Nephropathy Associated With Chronic Q Fever

Cited by 22 publications

References 18 publications

SCID Mouse Model for Lethal Q Fever

SCID Mouse Model for Lethal Q Fever

Endocarditis Due to Rare and Fastidious Bacteria

Prolif erative Glomerulonephritis Revealing Chronic Q Fever

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