Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome

Chan, P. T.; Lee, K. C.; Chong, Lai Yin; Lo, K. K.; Cheung, Yiu‐fai

doi:10.1111/j.1365-2230.2006.02213.x

Cited by 14 publications

(6 citation statements)

References 10 publications

(21 reference statements)

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“…Glomeruloid haemangioma is a unique abnormality among POEMS syndrome‐associated skin changes and observed in 9–35% of patients presenting as multiple red‐purple lesions on the trunk and proximal limbs; however, this lesion is rarely reported in patients without POEMS syndrome (Chan et al , ; Ferran & Gimenez‐Arnau, ; Chung et al , ). Thus, accurate identification of haemangioma may facilitate a more rapid diagnosis.…”

Section: Diagnosismentioning

confidence: 99%

New advances in the diagnosis and treatment of POEMS syndrome

Zhou

2013

Br J Haematol

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SummaryPOEMS syndrome is a clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Significant advances have been made in the diagnosis and treatment of POEMS syndrome over the last decade. Herein, the diagnostic criteria and characteristic features are reviewed, focusing the role of characteristic features in early diagnoses. Autologous peripheral blood stem cell transplantation has become the first-line treatment for younger patients with normal organ function. Autologous transplantation has resulted in a high response rate and durable remission. Moreover, transplantation-related morbidity and mortality has been significantly reduced over the past 5 years. Induction therapy before transplantation may improve the harvest of stem cells and decrease transplantation-related morbidity. Melphalan and dexamethasone is an effective and well-tolerated treatment for older patients or those with organ dysfunction. Novel agents may also offer benefits to patients with a poor performance status or renal dysfunction, and transform transplantation eligibility.

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Section: Diagnosismentioning

confidence: 99%

New advances in the diagnosis and treatment of POEMS syndrome

Zhou

2013

Br J Haematol

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“…Glomeruloid hemangiomas are very rare intravascular capillary hemangiomas, which structurally resemble the renal glomerulus, and are regarded to be specific for POEMS (acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome and/or multicentric Castleman's disease. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] During the preparation and publication of the article on papillary hemangiomas, it was noted on several occasions that pathologists appeared to have great difficulty in distinguishing papillary hemangiomas from glomeruloid hemangiomas. Most strikingly, some reviewers of a leading surgical pathology journal were reluctant to accept that the papillary hemangioma is a distinct entity with unique morphological features and clinicopathological context.…”

Section: Introductionmentioning

confidence: 99%

Papillary Hemangiomas and Glomeruloid Hemangiomas Are Distinct Clinicopathological Entities

Suurmeijer

2008

Int J Surg Pathol

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The author reviews and compares the clinicopathological features of papillary hemangiomas and glomeruloid hemangiomas, 2 rare, cutaneous intravascular capillary-type vascular lesions with overlapping morphological details. Immunostaining for collagen IV highlighted discriminating features in these lesions. Thin basement membranes and glomeruloid architecture are typical of glomeruloid hemangiomas, whereas papillae with thick mantles of a basement membrane- like matrix enveloping pericytes are prominent in papillary hemangiomas. Thus, collagen IV staining patterns provide further evidence that papillary and glomeruloid hemangiomas represent distinct histopathological entities. This additional technique should allow pathologists to readily distinguish between the lesions and make a proper diagnosis. What is important is that glomeruloid hemangiomas-often presenting in a spectrum of multiple cutaneous vascular lesions, including cherry hemangiomas-are a hallmark of POEMS (acronym for polyneuropathy, oganomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome and/or multicentric Castleman's disease, whereas papillary hemangiomas clinically present as innocent solitary cutaneous hemangiomas in otherwise healthy individuals.

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“…14 Studies of possible links of the globules to human herpes virus 8 have, in contrast, been inconclusive. [19][20][21][22] Similar EGs in endothelial cells have been described in many other cutaneous and noncutaneous lesions. These include granulation tissue, 7 pyogenic granuloma, 7 targetoid hemosiderotic hemangioma, 26 papillary hemangioma, 6 Kaposi's sarcoma, 9,10,27 littoral cell angioma of the spleen, 28 and angiosarcoma.…”

Section: Discussionmentioning

confidence: 97%

“…1,5,19 Putative angiogenetic factors that have been proposed to stimulate this capillary proliferation include Ig light chains phagocytized by endothelial cells and human herpes virus 8. [19][20][21][22] Although GH is now considered a hallmark for POEMS syndrome, recent reports have documented an identical lesion without POEMS syndrome. 13,14 Likewise, 2 of the cases described in this report (cases 1 and 2) had neither the defining stigmata of POEMS syndrome nor multicentric Castleman's disease.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS

Lee

Meier

Chan

et al. 2008

The American Journal of Dermatopathology

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Glomeruloid hemangiomas (GHs) are glomeruli-like capillary tufts lined by endothelial cells that contain periodic acid-Schiff (PAS) positive eosinophilic globules (EGs). These hemangiomas are characteristic cutaneous manifestation of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin changes). Hemangiomas histologically identical to GHs but not associated with POEMS have recently been designated as papillary hemangiomas. In this report, we present solitary head and neck GHs in 3 patients, 2 without POEMS, with particular attention to the characteristic EGs. We performed immunostains for hemoglobin A, kappa and lambda light chains, factor VIII-related antigen, CD31 and CD34, PAS stain after diastase digestion (PASD), and electron microscopic examinations on routinely fixed tissues containing EGs. Eosinophilic globules stained uniformly positive for PASD but only peripherally positive for hemoglobin and light chains on surfaces, with interiors negative for antigens. Factor VIII-related antigen and CD31 and CD34 confirmed cells containing EGs to be endothelial. Electron microscopic examination suggested that EGs are enlarged secondary lysosomes (thanatosomes). These features fail to support red blood cells or immunoglobulins as EG constituents. Glomeruloid hemangiomas may be vascular proliferations stimulated by endothelial cells' protein phagocytosis but not by phagocytosis of either hemoglobin-containing red blood cells or immunoglobulins. The vascular lesions in POEMS syndrome appear identical to papillary hemangioma in cases without the other syndromic manifestations.

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Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome

Cited by 14 publications

References 10 publications

New advances in the diagnosis and treatment of POEMS syndrome

New advances in the diagnosis and treatment of POEMS syndrome

Papillary Hemangiomas and Glomeruloid Hemangiomas Are Distinct Clinicopathological Entities

Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS

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