Glomerulonephritis and Exposure to Organic Solvents.

Ravnskov, Uffe; Forsberg, Björn; Skerfving, Staffan

doi:10.1111/j.0954-6820.1979.tb06106.x

Cited by 72 publications

(5 citation statements)

References 12 publications

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“…Case-control studies have indicated a greater risk of chronic glomerulonephritis, which can be idiopathic or part of Goodpasture Syndrome, among workers exposed to 0s (Zimmerman et al 1975). The relative risk of exposed compared with non-exposed persons was 3.9 (Ravnskov et al 1979). The difference between the groups was statistically significant.…”

Section: Ratio Of Age-standardized Prevalence Rates Between Women Ementioning

confidence: 78%

Multiple sclerosis among shoe and leather workers: An epidemiological survey in Florence

Amaducci

Inzitari

et al. 2009

Acta Neurologica Scandinavica

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The observation of many multiple sclerosis (MS) cases among shoe and leather workers prompted a survey of the risk of MS in this working population. Eighty-one patients with definite or probable MS alive in Florence on May 1st 1976 were interviewed regarding their occupation at onset of the disease. Five of the 41 patients working at the time had worked in shoe and leather factories. The relative risk for these workers was 4.87 compared to the general population and 4.91 compared t o the active population, both results being significantly different from one. This survey indicates an increased risk of MS among shoe and leather workers. Organic solvents, contained in large quantities in the glues used, may be involved in the pathogenetic mechanism through a possible interference with the immune system.

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Section: Ratio Of Age-standardized Prevalence Rates Between Women Ementioning

confidence: 78%

Multiple sclerosis among shoe and leather workers: An epidemiological survey in Florence

Amaducci

Inzitari

et al. 2009

Acta Neurologica Scandinavica

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“…1 ). Of these 19 studies, 12 case-control studies 3 4 5 8 18 19 20 21 22 23 24 25 were studies that were included in the previous meta-analysis performed by Ravnskov. 10 Two case-control studies 9 26 and 5 cohort studies 7 27 28 29 30 were newly included after the revised definition of CKD.…”

Section: Resultsmentioning

confidence: 99%

“…We were able to calculate the risk according to the degree of exposure in a total of 6 studies. 4 8 9 21 23 29 All these studies did not conduct a quantitative evaluation of organic solvent exposure. However, they all evaluated the exposure intensity qualitatively by examining occupational history, working conditions, and duration of employment by two or more industrial hygiene engineers.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of studies that analyzed some subgroups of exposure intensity, a survey was conducted on industrial hygienists on what solvent they were exposed to, what kind of work they were involved in, and their exposure period, which were then classified accordingly. 4 8 9 21 23 29 Overall, these studies differed in the criteria for setting the exposure level. However, exposure intensity was qualitatively evaluated in a survey performed by industrial hygiene engineers in all these studies.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition, studies have continuously published that organic solvents can affect the occurrence of chronic kidney disease (CKD), such as worsening of renal function, occurrence of proteinuria and glomerulonephritis (GN) since the 1970s. 3 4 5 6 7 …”

Section: Introductionmentioning

confidence: 99%

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Organic solvent exposure for the chronic kidney disease: updated systematic review with meta-analysis

Lim

2023

Ann Occup Environ Med

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Background Studies on the relationship between organic solvent exposure and chronic kidney disease (CKD) have presented inconsistent results. Definition of CKD has changed in 2012, and other cohort studies have been newly published. Therefore, this study aimed to newly confirm the relationship between organic solvent exposure and CKD through an updated meta-analysis including additional studies. Methods This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search was conducted on January 2, 2023 using Embase and MEDLINE databases. Case-control and cohort studies on the relationship between organic solvent exposure and CKD were included. Two authors independently reviewed full-text. Results Of 5,109 studies identified, a total of 19 studies (control studies: 14 and cohort studies: 5) were finally included in our meta-analysis. The pooled risk of CKD in the organic solvent exposed group was 2.44 (1.72–3.47). The risk of a low-level exposure group was 1.07 (0.77–1.49). The total risk of a high-level exposure group was 2.44 (1.19–5.00). The risk of glomerulonephritis was 2.69 (1.18–6.11). The risk was 1.46 (1.29–1.64) for worsening of renal function. The pooled risk was 2.41 (1.57–3.70) in case-control studies and 2.51 (1.34–4.70) in cohort studies. The risk of subgroup classified as ‘good’ by the Newcastle Ottawa scale score was 1.93 (1.43–2.61). Conclusions This study confirmed that the risk of CKD was significantly increased in workers exposed to mixed organic solvents. Further research is needed to determine the exact mechanisms and thresholds. Surveillance for kidney damage in the group exposed to high levels of organic solvents should be conducted. Trial Registration PROSPERO Identifier: CRD42022306521

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Occupational Exposure to Organic Solvents Causing Chronic Tubulointerstitial Nephritis

Narvarte

Saba²,

Ramírez³

1989

Arch Intern Med

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Glomerulonephritis and Exposure to Organic Solvents.

Cited by 72 publications

References 12 publications

Multiple sclerosis among shoe and leather workers: An epidemiological survey in Florence

Multiple sclerosis among shoe and leather workers: An epidemiological survey in Florence

Organic solvent exposure for the chronic kidney disease: updated systematic review with meta-analysis

Occupational Exposure to Organic Solvents Causing Chronic Tubulointerstitial Nephritis

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