Glomerulonephritis With Deposition of Australia Antigen-Antibody Complexes in Glomerular Basement Membrane

Combes, Burton; Shorey, James; Barrera, Arnaldo; Šťastný, Peter; Eigenbrodt, EdwinH.; Hull, AlanR.; Carter, NormanW.

doi:10.1016/s0140-6736(71)92572-4

Cited by 430 publications

(144 citation statements)

References 11 publications

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“…In our present series we too found the highest prevalence of HBsAg in MGN (80%). After the first report of Combes et al (1971) demonstrating HBsAg in MGN, several workers reported HBV markers in 20-6-100% of MGN (Takekoshi et al, 1978, 11 of 11 ; Slusarczyk et al, groups (Slusarczyk et al, 1980) and IgA nephropathies (Lai et al, 1987) have also been shown to be associated with HBs antigenaemia. Animal experiments and observations on human subjects have demonstrated that HBV-containing immune complexes may be formed in the course of HBV-induced acute and chronic hepatitis (Slusarczyk et al, 1980; Lesavre et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Serum and tissue positivity for hepatitis B virus markers in histopathologically proven glomerulonephropathies

Thyagarajan

Thirunalasundari

Subramanian

et al. 1989

Journal of Medical Microbiology

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Summary.To assess the pathogenic significance of hepatitis B virus (HBV) in glomerulonephritis (GN), 98 patients with histopathologically proven glomerulonephropathies were screened for HBV markers, complement components and levels of circulating immune complexes (CICs); and renal biopsies from 31 of them were examined for the presence of hepatitis B surface antigen (HBsAg), and its location, by immunoperoxidase staining. The HBsAg positive rate in the patients (who came from a population with 10% HBsAg positivity) ranged from 51.9% in minimum change nephrotic syndrome (MCNS) to 8 1.8% in patients with proliferative glomerulonephritis (PGN). Whereas 24.5% of the cases were positive for HBsAg only, 10.2% had anti-HBcIgM with HBsAg, 13.3% had HBeAg with HBsAg and 9.2% had HBsAg, HBeAg and anti-HBcIgM. Complement component C3 levels were decreased in all groups of G N studied, but C4 levels varied. CIC levels were significantly increased (p < 0.0 1) only in HBsAg-positive MCNS, focal glomerulosclerosis (FGS) and membranous glomerulonephritis (MGN). Of the 3 1 renal biopsies examined for the deposition of HBsAg, 4 (12.9%) were found to be positive for HBsAg in situ; 64.5% of biopsied patients were seropositive for HBsAg and 77.4% had CICs. All the four in-situ HBsAg-positive cases were seropositive for HBsAg, HBeAg and anti-HBcIgM with significantly high CIC levels (p < 0.01). HBsAg deposition was intracytoplasmic in the mesangial cells of the glomeruli, in the glomerular basement membrane or in the tubules, or in a combination of these sites.

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Section: Discussionmentioning

confidence: 99%

Serum and tissue positivity for hepatitis B virus markers in histopathologically proven glomerulonephropathies

Thyagarajan

Thirunalasundari

Subramanian

et al. 1989

Journal of Medical Microbiology

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“…This uncommon extrahepatic manifestation might be induced either by direct cytopathic effect of virus or interplay between viral, host and environmental factors (Congia et al, 1996;Mazzaro et al, 2000;Strassburg, et al, 1996). The association between hepatitis B virus (HBV) infection and renal involvement, mainly membranous nephropathy, was first reported in 1971 (Combes et al, 1971). Deposition of Australia antigen-antibody complexes in glomerular basement membrane was identified in renal tissue of glomerulonephritis.…”

Section: Nephropathymentioning

confidence: 99%

Metabolic Aspects of Hepatitis C Virus Infection

Huang¹,

Yu²,

Dai³

et al. 2012

Molecular Virology

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“…7,8 The pathogenetic role of HBV in renal disease has attracted much attention, since Combes et al reported glomerulonephritis with immune complexes of HBsAg and its antibody (anti-HBs) in a patient infected with HBV. 9 Various morphological patterns including membranous nephropathy (MN), mesangiocapillary glomeruonephritus (MCGN), minimal change nephropathy (MCN), mesangioproliferative glomerulonephritis (MPGN) have been described. 10,11 In 1863, Austin Flint made a special reference to oliguria in cirrhotic patients.…”

Section: Introductionmentioning

confidence: 99%

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

2016

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Glomerulonephritis With Deposition of Australia Antigen-Antibody Complexes in Glomerular Basement Membrane

Cited by 430 publications

References 11 publications

Serum and tissue positivity for hepatitis B virus markers in histopathologically proven glomerulonephropathies

Serum and tissue positivity for hepatitis B virus markers in histopathologically proven glomerulonephropathies

Metabolic Aspects of Hepatitis C Virus Infection

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

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