Glomérulopathie à dépôts mésangiaux d'IgA au cours d'une hémochromatose primitive

Primary (pIgAN), secondary IgA nephropathy (sIgAN), and IgA-associated nephropathy can be distinguished. While pIgAN has been thoroughly studied, information about the etiology of sIgAN remains scarce. As concerns sIgAN, several studies suggest that different etiologic factors play a role and ultimately lead to a pathophysiologic process similar to that of pIgAN. In this article, we review a vast number of cases in order to determine the novel putative underlying diseases of sIgAN. Moreover, updates on the common pathophysiology of primary disorders and sIgAN are presented. We identified liver, gastrointestinal, oncological, dermatological, autoimmune, and respiratory diseases, as well as infectious, iatrogenic, and environmental factors, as triggers of sIgAN. As novel biological therapies for listed underlying diseases emerge, we suggest implementing drug-induced sIgAN as a new significant category. Clinicians should acknowledge the possibility of sIgAN progression in patients treated with TNF-α inhibitors, IL-12/IL-23-inhibitors, immune checkpoint inhibitors, CTLA-4, oral anticoagulants, thioureylene derivatives, and anti-vascular endothelial growth factor drugs.

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“…Prior to this patient, Gouet et al also described a patient with hemochromatosis and subsequent sIgAN [ 129 ].…”

Section: Iga Nephropathy Secondary To Liver Diseasesmentioning

confidence: 99%

Secondary IgA Nephropathy and IgA-Associated Nephropathy: A Systematic Review of Case Reports

Tota

Baron

Musial

et al. 2023

JCM

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A Case of IgA Nephropathy and Renal Hemosiderosis Associated with Primary Hemochromatosis

et al. 2008

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Renal hemosiderosis and rapidly progressive glomerulonephritis associated with primary hemochromatosis

et al. 2014

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Hereditary hemochromatosis leads to the accumulation of iron in many organs including the liver, spleen and heart and results in injury and dysfunction of these organs. On the other hand, iron accumulation and functional impairment in kidney is extremely rare. We report a 61-year-old male patient with hereditary hemochromatosis, in whom the renal function was deteriorated rapidly. Renal biopsy revealed crescentic glomeruli and hemosiderin accumulation in tubular epithelial cells.

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Glomérulopathie à dépôts mésangiaux d'IgA au cours d'une hémochromatose primitive

Cited by 5 publications

References 2 publications

Secondary IgA Nephropathy and IgA-Associated Nephropathy: A Systematic Review of Case Reports

Secondary IgA Nephropathy and IgA-Associated Nephropathy: A Systematic Review of Case Reports

A Case of IgA Nephropathy and Renal Hemosiderosis Associated with Primary Hemochromatosis

Renal hemosiderosis and rapidly progressive glomerulonephritis associated with primary hemochromatosis

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