Glomus tumours: a clinico-pathological survey

Taaffe, A.; Barker, Diane; Wyatt, E.H.; Bury, Henry

doi:10.1111/j.1365-2230.1980.tb01692.x

Cited by 24 publications

(17 citation statements)

References 14 publications

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“…[516] Originally, glomus cells were believed to arise from endothelial cells; however, recent histologic evidence points towards their being a type(s) of smooth muscle cell. [171819] Histochemical staining reveals glomus cells to be positive for vimentin and alpha-smooth muscle actin, but negative for desmin. [2021] All our patients showed the typical findings associated with solid glomus tumours, but immunochemistry could not be performed because of resource constraints.…”

Section: Discussionmentioning

confidence: 99%

Transungual surgical excision of subungual glomus tumour

Grover¹,

Khurana²,

Jain³

et al. 2013

J Cutan Aesthet Surg

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Background:Glomus tumours are rare vascular tumours arising subungually in fingernails. Surgical excision provides histopathologic diagnosis and rapid resolution of symptoms.Objective:Present study was aimed at delineating common presentations and long-term treatment outcome of this rare subungual tumour. Patients and Methods: The clinical features and imaging results for 10 patients with subungual glomus tumours were recorded. All were treated with transungual excision. Per-operative findings and, treatment outcomes were recorded and analysed.Results:Females outnumbered males with average age being 33.3 ± 7.55 years. Presenting symptoms were severe pain (100%); nail-plate discoloration and onycholysis. X-ray was normal in 70%, though a magnetic resonance imaging done for five, helped visualise the lesion in three patients. The tumour involved nail bed in five cases and matrix in five, with an average size being 6.1 ± 2.13 mm (range 3-11 mm). An average follow-up of 16.8 months (range 8-24 months) was largely uneventful with longitudinal ridging in two cases and recurrence in two (both attributed to a sister lesion).Conclusion:Subungual glomus tumours have characteristic clinical presentation. Imaging is helpful pre-operatively but has a low success rate. Transungual surgical excision is safe and effective, allowing better visualisation, easy exploration and minimal long-term complications.

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Section: Discussionmentioning

confidence: 99%

Transungual surgical excision of subungual glomus tumour

Grover¹,

Khurana²,

Jain³

et al. 2013

J Cutan Aesthet Surg

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“…The multiple form has been reported to be linked to chromosome 1p21‐22, which encodes the glomulin protein 5 . The site most commonly involved is the subungual area of the finger, other common sites including the palm, wrist, forearm and foot 6,7 . However, glomus tumors have also been described in extracutaneous sites, such as bone, stomach, colon, trachea and mediastinum 8 .…”

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confidence: 99%

“…5 The site most commonly involved is the subungual area of the finger, other common sites including the palm, wrist, forearm and foot. 6,7 However, glomus tumors have also been described in extracutaneous sites, such as bone, stomach, colon, trachea and mediastinum. 8 Typically, they are small (less than 1 cm diameter), reddish-blue nodules and classically present with paroxysmal severe pain, radiating away from the lesion, which can be precipitated by pressure or changes in temperature, particularly exposure to cold.…”

mentioning

confidence: 99%

Symplastic glomus tumor – a rare but distinct benign histological variant with analogy to other ‘ancient’ benign skin neoplasms

et al. 2009

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A 78-year-old woman presented with a nail deformity of the index finger of the left hand associated with paroxysmal pain upon cold exposure. Histologically, a well-circumscribed tumor of 3 mm diameter was found in the dermis. The neoplastic cells in some areas were of pronouncedly variable size and cytomorphology, mostly epithelioid in shape, with eosinophilic cytoplasm and indistinctly defined cell borders. Pronounced nuclear pleomorphism and atypia were striking features, but no mitotic figures were noted. Multinuclear cells were present as were numerous small-to-medium vessels throughout the tumor. The tumor stroma showed myxoid areas. Immunohistochemistry showed cytoplasmic and membranous expression of smooth muscle actin and vimentin. The histological features and immunoprofile were consistent with the diagnosis of symplastic glomus tumor, a rare histological variant, which has been defined as a glomus tumor exhibiting marked nuclear atypia, in the absence of any other criteria for malignancy. The biological behavior of the tumor is benign. It is essential to differentiate this entity from malignant glomus tumor, which has metastatic potential. Even prominent cellular atypia and nuclear pleomorphism in a glomus tumor as in our case is not a marker of malignancy in the absence of additional criteria.

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“…Glomus cells are rounded or polygonal cells with centrally placed round or ovoid nuclei and have scant eosinophilic cytoplasm. 12 Multiple GVMs are less well circumscribed and less solid- appearing than solitary GVMs. They have more narrow and focal aggregates of glomus cells and larger vascular spaces than solitary GVMs.…”

Section: Commentmentioning

confidence: 99%

“…Multiple GVMs are rare and account for less than 10% of all reported cases. 12,19 They have an earlier age of onset than solitary lesions, with one third presenting before 20 years of age. Multiple lesions can be subdivided into localized, disseminated, and congenital plaque-type forms.…”

Section: Commentmentioning

confidence: 99%

Congenital Plaque-Type Glomuvenous Malformations Presenting in Childhood

Mallory¹,

Enjolras²,

Boon³

et al. 2006

Arch Dermatol

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Background: Glomuvenous malformations (GVMs) are now considered a separate entity from venous malformations. The rarest type of GVM is the generalized congenital plaque-type GVM. Observations: We present 10 new cases of congenital plaque-type GVM and describe their clinical progression and treatment. Mutations in the glomulin gene were found in those patients who participated in the genetic study. Conclusions: Congenital plaque-type GVMs are unique in their congenital nature, extensive distribution, difficult to diagnose and treat, and progressive involvement after birth. Most cases are familial, yet affected relatives usually have only minor lesions. The lesions of congenital plaque-type GVM are severe, visible at birth, and usually mistaken for extensive venous malformations.Vascular malformations are divided by hemodynamic type into slow-flow and fast-flow lesions. Slow-flow lesions are subcategorized as capillary, lymphatic, and venous. 1 Capillary malformations are flat, sharply demarcated, redpink vascular stains of the skin commonly referred to as port-wine stains. These persist throughout life and are characterized histologically by dilated capillaries within the dermis. They slowly increase in size with age. Lymphatic malformations are spongelike collections of abnormal channels and spaces that contain clear lymphatic fluid, causing an excess of fluid to accumulate and dilate the lymphatic channels. This results in swelling of the affected area and, if extensive, can cause enlargement of soft tissues and bones.

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Glomus tumours: a clinico-pathological survey

Abstract: Summary Twenty‐three cases of glomus tumours seen at the Dermatology out‐patients of two hospitals are reported. Their principal clinical and histopathological features are recorded and the recent literature reviewed. The findings are compared with previously published accounts.

Cited by 24 publications

References 14 publications

Transungual surgical excision of subungual glomus tumour

Transungual surgical excision of subungual glomus tumour

Symplastic glomus tumor – a rare but distinct benign histological variant with analogy to other ‘ancient’ benign skin neoplasms

Congenital Plaque-Type Glomuvenous Malformations Presenting in Childhood

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