Glomuvenous malformations: dual PDL-Nd:YAG laser approach

Abstract

Glomuvenous malformations are uncommon simple vascular malformations that might be present at birth or appear during childhood that have been classically classified as a subtype of venous malformations. Sclerotherapy and surgery have been used in the past as treatments for this condition although with disappointing results in large glomangiomas. The treatment of these lesions has still not been standardized. We conducted a retrospective study of 17 patients treated with dual wavelength PDL-Nd:YAG. The majority of the patients experience a reduction of at least a 60% in their glomuvenous malformations. Treatment was well-tolerated, and adverse effects were rare.

Multiple Bluish Nodules in a 20-Year-Old Female with Similar Lesions in Her Father

“…Many case reports and studies demonstrated satisfying efficacy using laser treatments on GVM lesions. Dual-wavelength Pulsed Dye Laser and Neodynium-doped Yttrium Aluminium Garnet laser (PDL-Nd:YAG) showed the most promising results in 60% of size reduction and improvement in color with safety profile [20], the youngest patient successfully treated was reported of a 6-month-old girl, with less cutaneous adverse effects compared to Nd:YAG alone, the latter more frequently resulted in ulceration and scarring, especially in children [21].…”

“…PDL allows greater absorption of the Nd:YAG laser due to the production of methemoglobin via hemoglobin, requiring less fluencies of the latter and therefore a decreased risk of adverse effects [19]. Focal GVM lesions showed better clinical outcome than plaque-like lesions treating with this laser system, while the latter had a greater risk of ulceration and atrophic scarring [20].…”

Venous Malformations in Childhood: Clinical, Histopathological and Genetics Update

“…Surgery can be considered for cosmetically disturbing solitary lesions. Nd:YAG laser therapy and sclerotherapy have shown to be a successful treatment in some cases [ 33 , 34 , 35 , 36 ].…”

Assessing subject diversity by condition and trial phase in clinical trials

“…More recently, some studies reported a successful approach with the dual PDL-Nd:YAG laser. 5 In our cases, we decided on an expectant attitude since the lesions do not interfere with their quality of life.To conclude, we report the glomulin pathogenic mutation c. 1319G > A, p.Trp440*, which has not been reported to date associated with glomuvenous malformation patients. Defining the causative mutation is extremely important in genetic counseling.…”

“…More recently, some studies reported a successful approach with the dual PDL-Nd:YAG laser. 5 In our cases, we decided on an expectant attitude since the lesions do not interfere with their quality of life.…”