Glove allergy due to 1,3‐diphenylguanidine

Pişkin, Gamze; Meijs, M. M.; Ham, Rens; Bos, Jan D.

doi:10.1111/j.0105-1873.2006.0729d.x

Cited by 21 publications

(14 citation statements)

References 2 publications

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“…This was a study from Germany, where zinc diethyl dithiocarbamate is the only carbamate tested within the baseline series, and this may explain why no change was shown. Other recent reports have highlighted increasing sensitization to 1,3‐DPG (part of the carba mix) attributable to gloves .…”

Section: Discussionmentioning

confidence: 93%

UK rates of occupational skin disease attributed to rubber accelerators, 1996–2012

et al. 2015

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These data show a falling reported incidence of occupational ACD attributed to rubber chemicals, but within this a significant rise attributable to the constituents of the carba mix. Clinicians should recognize the changing diversity of chemicals used in rubber manufacturing, and consider including carba mix in their baseline series and testing beyond this in suspect cases to avoid false-negative results.

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Section: Discussionmentioning

confidence: 93%

UK rates of occupational skin disease attributed to rubber accelerators, 1996–2012

et al. 2015

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“…From several European countries, increasing numbers of sensitization to DPG from protective medical gloves are being reported. [26][27][28] Hence, although DPG 1% pet. is known as a problematic patch test substance often eliciting doubtful or weak (presumably false) positive reactions, 24 clinical relevance of positive reactions to DPG should thoroughly be checked in every individual case.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is notable that sensitization to 1,3‐diphenylguanidine (DPG), which is tested in the rubber series only, was as frequent as sensitization to one of the MBT derivatives in this context (1.6% vs. 1.5%). From several European countries, increasing numbers of sensitization to DPG from protective medical gloves are being reported . Hence, although DPG 1% pet.…”

Section: Discussionmentioning

confidence: 99%

Occupational contact sensitization in female geriatric nurses: Data of the Information Network of Departments of Dermatology (IVDK) 2005–2014

Schubert

Bauer

Molin

et al. 2016

Acad Dermatol Venereol

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“…Bempong and Hall (1983) reported that this compound decreased sperm count and altered sperm morphology in rodents, although these observations were not confirmed in an independent study (Koeter et al , 1992). Recently, 1,3-diphenylguanidine was reported to be involved in the development of allergic contact dermatitis (Piskin et al , 2006). Malachite green, a triarylmethane dye, is widely used as a parasiticide in the aquaculture industry and is also used as a food and clothing coloring agent (Srivastava et al , 2004).…”

Section: Discussionmentioning

confidence: 99%

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

Xia¹,

Shahane²,

Huang³

et al. 2011

Toxicology and Applied Pharmacology

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The human ether-a-go-go-related gene (hERG) channel, a member of a family of voltage-gated potassium (K + ) channels, plays a critical role in the repolarization of the cardiac action potential. The reduction of hERG channel activity as a result of adverse drug effects or genetic mutations may cause QT interval prolongation and potentially lead to acquired long QT syndrome. Thus, screening for hERG channel activity is important in drug development. Cardiotoxicity associated with the inhibition of hERG channels by environmental chemicals is also a public health concern. To assess the inhibitory effects of environmental chemicals on hERG channel function, we screened the National Toxicology Program (NTP) collection of 1408 compounds by measuring thallium influx into cells through hERG channels. Seventeen compounds with hERG channel inhibition were identified with IC 50 potencies ranging from 0.26 to 22 μM. Twelve of these compounds were confirmed as hERG channel blockers in an automated whole cell patch clamp experiment. In addition, we investigated the structure-activity relationship of seven compounds belonging to the quaternary ammonium compound (QAC) series on hERG channel inhibition. Among four active QAC compounds, tetra-n-octylammonium bromide was the most potent with an IC 50 value of 260 nM in the thallium influx assay and 80 nM in the patch clamp assay. The potency of this class of hERG channel inhibitors appears to depend on the number and length of their aliphatic side-chains surrounding the charged nitrogen. Profiling environmental compound libraries for hERG channel inhibition provides information useful in prioritizing these compounds for cardiotoxicity assessment in vivo.

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Glove allergy due to 1,3‐diphenylguanidine

Cited by 21 publications

References 2 publications

UK rates of occupational skin disease attributed to rubber accelerators, 1996–2012

UK rates of occupational skin disease attributed to rubber accelerators, 1996–2012

Occupational contact sensitization in female geriatric nurses: Data of the Information Network of Departments of Dermatology (IVDK) 2005–2014

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

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