GLP-1 improves survival and preserves diastolic function and cardiac glucose oxidation in rats with pressure overload

Nguyen, TD; Shingu, Yasushige; Amorim, PA; Schwarzer, Martin; Doenst, Torsten

doi:10.1055/s-0031-1297679

Cited by 1 publication

(1 citation statement)

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“…142 Since GLP-1 treatment increased insulin secretion in these rats, it is unclear whether GLP-1 or insulin accounted for these effects. In contrast, in our rat model of pressure overload, we also observed improved functional outcome and preserved cardiac glucose oxidation without changes in insulin levels, 143 which suggest insulin-independent effects of GLP-1. There is also evidence that GLP1 might mediate cardiovascular effects via GLP-1 receptor independent mechanisms.…”

Section: Potential Metabolic Therapy For Heart Failurecontrasting

confidence: 81%

Cardiac Metabolism in Heart Failure

Doenst

Nguyễn

Abel³

2013

Circulation Research

887

423

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The heart has a high rate of ATP production and turnover which is required to maintain its continuous mechanical work. Perturbations in ATP generating processes may therefore affect contractile function directly. Characterizing cardiac metabolism in heart failure revealed several metabolic alterations termed metabolic remodeling, ranging from changes in substrate utilization to mitochondrial dysfunction, ultimately resulting in ATP deficiency and impaired contractility. However, ATP depletion is not the only relevant consequence of metabolic remodeling during heart failure. By providing cellular building blocks and signaling molecules, metabolic pathways control essential processes such as cell growth and regeneration. Thus, alterations in cardiac metabolism may also affect the progression to heart failure by mechanisms beyond ATP supply. Our aim is therefore to highlight that metabolic remodeling in heart failure not only results in impaired cardiac energetics, but also induces other processes implicated in the development of heart failure such as structural remodeling and oxidative stress. Accordingly, modulating cardiac metabolism in heart failure may have significant therapeutic relevance that goes beyond the energetic aspect.

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Section: Potential Metabolic Therapy For Heart Failurecontrasting

confidence: 81%