Glucagon

Hyperglycemia was observed in frogs after single ip injections of doses above 50 &kg of adrenalin and glucagon. Blood glucose responses were maximal at 3 hr and lasted at least 5 hr. Lactacidemia was apparent after treatment with adrenalin at doses of 50 &kg and above. The increase in lactate was apparent by 1 hr and had dropped to control levels by 5 hr. Tissue giycogen loss was not observed after treatment with either hormone in adults. Preliminary studies with tadpoles indicated a hyperglycemic response to adrenalin and glucagon at doses of 1.0 mgikg and an increase in lactate after injection of a 1 .O mg/kg dose of adrenalin. Liver glycogen loss was observed following glucagon but not adrenalin. Both hormones stimulated glucose release from liver slices of frogs and tadpoles.

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Glucagon

Cited by 8 publications

References 568 publications

Lowering of Plasma Lipids, The Major Effect of Repeated Glucagon Administration in Rats

Lowering of Plasma Lipids, The Major Effect of Repeated Glucagon Administration in Rats

Serum Immunoreactive Insulin in Clinical Practice

A comparison of adrenalin and glucagon effects on carbohydrate levels of larval and adult Rana pipiens

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