Glucagon and Glucagon-like Peptides in Fishes

Plisetskaya, Erika M.; Mommsen, Thomas P.

doi:10.1016/s0074-7696(08)60885-2

Cited by 131 publications

(72 citation statements)

References 218 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, physiologic concentrations of glucagon inhibited both basal and GHstimulated IGF-I mRNA expression and secretion into culture medium in rat hepatocytes (Denver & Nicoll 1994). GLP is a pancreatic hormone with metabolic effects similar to glucagon on the liver in fishes, and is often more potent than glucagon (Plisetskaya & Mommsen 1996). The present study provides no evidence for a role for GLP in the regulation of the GH/IGF axis.…”

Section: Discussioncontrasting

confidence: 68%

“…However, inhibition did not occur at lower concentrations of glucagon. Physiologic concentrations of glucagon experienced by the liver are 10 10 M, and primary fish hepatocytes respond metabolically to glucagon concentrations as low as 10 8 M (Plisetskaya & Mommsen 1996). Therefore, the effect of glucagon found in the present study is likely to be pharmacologic.…”

Section: Discussionmentioning

confidence: 55%

See 1 more Smart Citation

Metabolic hormones modulate the effect of growth hormone (GH) on insulin-like growth factor-I (IGF-I) mRNA level in primary culture of salmon hepatocytes

Pierce

Fukada²,

Dickhoff³

2005

Journal of Endocrinology

View full text Add to dashboard Cite

Liver production of insulin-like growth factor-I (IGF-I) is a major point of control in the growth hormone (GH)/IGF axis, the endocrine system regulating body growth in fishes and other vertebrates. Pituitary GH stimulates hepatocyte production of IGF-I; however, in catabolic states, hepatocyte GH resistance results in decreases in liver IGF-I production. To investigate endocrine mechanisms leading to the development of hepatocyte GH resistance, we examined the regulation of IGF-I mRNA level by GH and metabolic hormones in primary culture of salmon hepatocytes. Cells were cultured in RPMI medium, and exposed to insulin (Ins, 10 6

show abstract

Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 55%

Metabolic hormones modulate the effect of growth hormone (GH) on insulin-like growth factor-I (IGF-I) mRNA level in primary culture of salmon hepatocytes

Pierce

Fukada²,

Dickhoff³

2005

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The primary peptides under investigation have been insulin, glucagon (GLU), and glucagon-like peptide (GLP), somatostatin (SST), and members of pancreatic polypeptide (PP) family, namely neuropeptide tyrosine (NPY), pancreatic polypeptide (PP), and peptide tyrosine tyrosine (PYY). The underlying objectives of studies concerned with isolation and description of the primary structure are to explain both the biological activity of these hormones within the organisms in question and to compare amino acid sequences so as to expand our knowledge of molecular evolution of regulatory peptides (Conlon, 1995;Larhammar, 1996;Plisetskaya and Mommsen, 1996). Immunohistochemistry has been the primary tool for identifying the distribution of the endocrine cells within the stomach, intestine, and the endocrine pancreas, while electron microscopy and immunocytochemistry have been useful in defining the characteristics of the cell types.…”

mentioning

confidence: 99%

The endocrine cells in the gastroenteropancreatic system of the bowfin, Amia calva L.: An immunohistochemical, ultrastructural, and immunocytochemical analysis

Youson¹,

Al‐Mahrouki²,

Naumovski³

et al. 2001

Journal of Morphology

View full text Add to dashboard Cite

The gastroenteropancreatic (GEP) endocrine system of bowfin (Amia calva) was described using light and electron microscopy and immunological methods. The islet organ (endocrine pancreas) consists of diffusely scattered, mostly small islets and isolated patches of cells among and within the exocrine acini. The islets are composed of abundant, centrally located B cells immunoreactive to bovine and lamprey insulin antisera and D cells showing a widespread distribution and specificity to somatostatin antibodies. A and F cells are present at the very periphery of the islets and are immunoreactive with antisera against glucagon (and glucagon-like peptide) and several peptides of the pancreatic polypeptide (PP)-family, respectively. The peptides of the two families usually collocates within the same peripheral islet cells and are the most common immunoreactive peptides present in the extra-islet tissue. Immunocytochemistry and fine structural observations characterised the granule morphology for B and D cells and identified two cell types with granules immunoreactive to glucagon antisera. These two putative A cells had similar granules, which were distinct from either B or D cells, but one of the cells had rodshaped cytoplasmic inclusions within cisternae of what appeared to be rough endoplasmic reticulum. The inclusions were not immunoreactive to either insulin or glucagon antisera. Only small numbers of cells in the stomach and intestine immunoreacted to antisera against somatostatin, glucagon, and PP-family peptides. The paucity of these cells was reflected in the low concentrations of these peptides in intestinal extracts. The GEP system of bowfin is not unlike that of other actinopterygian fishes, but there are some marked differences that may reflect the antiquity of this system and/or may be a consequence of the ontogeny of this system in this species.

show abstract

“…The research on intermediary metabolism of carbohydrate suggests that lack of regulation of hepatic gluconeogenesis is common in carnivorous fish compared to mammal (Panserat et al, 2001a;Hemre et al, 2002). This is perhaps due to the difference in structure and function of related hormone (insulin, insulin-like growth factor-I (IGF-I) and glucagons) and their receptors (Mommsen and Moon, 1990;Mommsen and Plisetskaya, 1991;Plisetskaya and Mommsen, 1996;Navarro et al, 1999;Moon, 2001). So in carnivorous fish, gluconeogenesis remain active when ingested glucose was high, which induced a high blood glucose level (Deng et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Nutritional homeostasis in carnivorous southern catfish (Silurus meridionalis): is there a mechanism for increased energy expenditure during carbohydrate overfeeding?

Xie²

2004

Comparative Biochemistry and Physiology Part A: Molecular &

View full text Add to dashboard Cite

Glucagon and Glucagon-like Peptides in Fishes

Cited by 131 publications

References 218 publications

Metabolic hormones modulate the effect of growth hormone (GH) on insulin-like growth factor-I (IGF-I) mRNA level in primary culture of salmon hepatocytes

Metabolic hormones modulate the effect of growth hormone (GH) on insulin-like growth factor-I (IGF-I) mRNA level in primary culture of salmon hepatocytes

The endocrine cells in the gastroenteropancreatic system of the bowfin, Amia calva L.: An immunohistochemical, ultrastructural, and immunocytochemical analysis

Nutritional homeostasis in carnivorous southern catfish (Silurus meridionalis): is there a mechanism for increased energy expenditure during carbohydrate overfeeding?

Contact Info

Product

Resources

About