Glucagon Effects on Ischemic Vasodilatation in the Isolated Rat Heart

Rosić, Mirko; Pantović, Suzana; Rosić, Gvozden; Lucic, Aleksandra Tomic; Labudović, Tatjana; Živković, Vladimir; Jakovljević, Vladimir

doi:10.1155/2010/231832

Cited by 9 publications

(10 citation statements)

References 29 publications

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“…On that way glucagon may prevent histamine release from cardiac mast cells by increasing the NO production and thus stabilizing cardiac mast cells. This is in accordance with the results of our previous study [ 63 ] in which we investigated the influence of glucagon on ischemic vasodilatation of the isolated rat heart.…”

Section: Discussionsupporting

confidence: 93%

Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Rosić

Parodi

Jakovljević

et al. 2014

BioMed Research International

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We estimated the influence of acute glucagon applications on 3H-histamine uptake by the isolated guinea-pig heart, during a single 3H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO, O2 −, and H2O2 in the venous effluent during anaphylaxis. Before anaphylaxis, glucagon pretreatment does not change 3H-histamine Umax and the level of endogenous histamine. At the same time, in the presence of glucagon, 3H-histamine Unet is increased and backflux is decreased when compared to the corresponding values in the absence of glucagon. During anaphylaxis, in the presence of glucagon, the values of 3H-histamine Umax and Unet are significantly higher and backflux is significantly lower in the presence of glucagon when compared to the corresponding values in the absence of glucagon. The level of endogenous histamine during anaphylaxis in the presence of glucagon (6.9–7.38 × 10−8 μM) is significantly lower than the histamine level in the absence of glucagon (10.35–10.45 × 10−8 μM). Glucagon pretreatment leads to a significant increase in NO release (5.69 nmol/mL) in comparison with the period before glucagon administration (2.49 nmol/mL). Then, in the presence of glucagon, O2 − level fails to increase during anaphylaxis. Also, our results show no significant differences in H2O2 levels before, during, and after anaphylaxis in the presence of glucagon, but these values are significantly lower than the corresponding values in the absence of glucagon. In conclusion, our results show that glucagon increases NO release and prevents the increased release of free radicals during anaphylaxis, and decreases histamine level in the venous effluent during cardiac anaphylaxis, which may be a consequence of decreased histamine release and/or intensified histamine capturing by the heart during anaphylaxis.

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Section: Discussionsupporting

confidence: 93%

Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Rosić

Parodi

Jakovljević

et al. 2014

BioMed Research International

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“…Furthermore, glucagon is able to decrease histamine-induced cardiac injury during reperfusion [ 2 ] and restores the pressure of the coronary perfusion during ischemic vasodilation [ 24 ].…”

Section: Glucagon Beyond Glucose Metabolismmentioning

confidence: 99%

Glucagon and heart in type 2 diabetes: new perspectives

Ceriello

Genovese

Mannucci

et al. 2016

Cardiovasc Diabetol

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Increased levels of glucagon in type 2 diabetes are well known and, until now, have been considered deleterious. However, glucagon has an important role in the maintenance of both heart and kidney function. Moreover, in the past, glucagon has been therapeutically used for heart failure treatment. The new antidiabetic drugs, dipeptidyl peptidase-4 inhibitors and sodium-glucose co-transporter-2 inhibitors, are able to decrease and to increase glucagon levels, respectively, while contrasting data have been reported regarding the glucagon like peptide 1 receptors agonists. The cardiovascular outcome trials, requested by the FDA, raised some concerns about the possibility that the dipeptidyl peptidase-4 inhibitors can precipitate the heart failure, while, at least for empagliflozin, a positive effect has been shown in decreasing both cardiovascular death and heart failure. The recent LEADER Trial, showed a significant reduction of cardiovascular death with liraglutide, but a neutral effect on heart failure. A possible explanation of the results with the DPPIV inhibitors and empagliflozin might be related to their divergent effect on glucagon levels. Due to unclear effects of glucagon like peptide 1 receptor agonists on glucagon, the possible role of this hormone in the Leader trial remains unclear.

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“…Glucagon agonism has been shown to regulate lipid metabolism and energy expenditure, as well as reduce histamine-induced cardiac injury during reperfusion. 52 …”

Section: Beyond Glucose Homeostasismentioning

confidence: 99%

The metabolic actions of glucagon revisited

et al. 2010

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The initial identification of glucagon as a counter-regulatory hormone to insulin revealed this hormone to be of largely singular physiological and pharmacological purpose. Glucagon agonism, however, has also been shown to exert effects on lipid metabolism, energy balance, body adipose tissue mass and food intake. The ability of glucagon to stimulate energy expenditure, along with its hypolipidemic and satiating effects, in particular, make this hormone an attractive pharmaceutical agent for the treatment of dyslipidemia and obesity. Studies that describe novel preclinical applications of glucagon, alone and in concert with glucagon-like peptide 1 agonism, have revealed potential benefits of glucagon agonism in the treatment of the metabolic syndrome. Collectively, these observations challenge us to thoroughly investigate the physiology and therapeutic potential of insulin's long-known opponent.

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Glucagon Effects on Ischemic Vasodilatation in the Isolated Rat Heart

Cited by 9 publications

References 29 publications

Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Glucagon and heart in type 2 diabetes: new perspectives

The metabolic actions of glucagon revisited

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Glucagon Effects on Ischemic Vasodilatation in the Isolated Rat Heart

Cited by 9 publications

References 29 publications

Glucagon Effects on3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Glucagon Effects on3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Glucagon and heart in type 2 diabetes: new perspectives

The metabolic actions of glucagon revisited

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Product

Resources

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Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis

Glucagon Effects on³H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis