Glucagon, Insuline Et Regulation Endocrine De La Glycemie Chez Le Canard

Mialhe, P

doi:10.1530/acta.0.028s019

Cited by 36 publications

(41 citation statements)

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“…All these observations taken together indicate stimulated insulin sensitivity, together with attenuated glucagon responsiveness, in chicks with hypocorticalism during the first 30 d of post-natal development. The proposed role of corticosterone in potentiating the action of glucagon and inhibiting that of insulin, is consistent with the observations of Mialhe (1958; on hypophysectomised ducks. The increased hepatic glycogen content and hypoglycemia occurring in response to DXM treatment in chicks (Joseph and Ramachandran, 1992) support the concept of a permissive role of corticosteroids in establishing and maintaining carbohydrate homeostasis by way of their modulatory actions on pancreatic hormones.…”

Section: Discussionsupporting

confidence: 88%

“…During this phase of the establishment of the appropriate adult type hormonal milieu, disturbing any of the hormonal components could affect carbohydrate metabolism. Corticosterone is one of the hormones influencing the actions of pancreatic hormones (Mialhe, 1958(Mialhe, , 1969) and either hypo-or hypercorticalism is likely to interact with pancreatic hormones. Because disturbed carbohydrate metabolism occurs under chronic hypo-or hypercorticalism in one-month-old chicks (Joseph and Ramachandran, 1992), the glucose tolerance test provides a clue to the functional status of pancrease, specifically the /?…”

Section: Discussionmentioning

confidence: 99%

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Dexamethasone‐induced alterations in glucose tolerance and, insulin, glucagon and adrenaline responses during the first month in white leghorn chicks

Joseph¹,

Dandekar²,

Ramachandran³

1996

British Poultry Science

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1. Alterations in glucose tolerance and, insulin, glucagon and adrenaline responses in dexamethasone (DXM)-treated (induced hypocorticalism) chicks have been evaluated chronologically during the first month of development of White Leghorn chicks. 2. Alterations in glucose tolerance and, insulin resistance and glucagon and adrenaline responses in dexamethasonised chicks were recorded. Control chicks too displayed differential glucose tolerance and, insulin, glucagon and adrenaline responses on a chronological basis. 3. The observations suggest increased insulin and adrenaline sensitivity in the first fortnight and gradually increasing glucagon response in the second fortnight in neonatal chicks. 4. Furthermore, increased insulin sensitivity and attenuated glucagon responsiveness was also associated with DXM-induced hypocorticalism.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Dexamethasone‐induced alterations in glucose tolerance and, insulin, glucagon and adrenaline responses during the first month in white leghorn chicks

Joseph¹,

Dandekar²,

Ramachandran³

1996

British Poultry Science

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“…As the duck appears to be an interesting species for studies on pancreatic hormone regulation [17,18] the present study was undertaken to explore the response of pancreatic hormones to somatostatin infusion in ducks.…”

Section: Introductionmentioning

confidence: 99%

Somatostatin stimulates glucagon secretion in ducks

et al. 1980

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Summary.In normal fasting ducks, a somatostatin infusion (800ng/kg/min for 30min) elicited a prompt inhibition of insulin secretion, plasma levels falling from 140 _+ 20 to 20 + 6 pg Eq/ml as observed in mammals. -However plasma glucagon-likeimmunoreactivity shown to be decreased in mammals by somatostatin was sharply increased from a mean basal level of 1.46 + 0.13 ng Eq/ml to 6.61 + 0.77 ng Eq/ml. This effect was not mediated via inhibition of growth hormone secretion since it was also observed in hypophysectomised ducks. Despite the fall in plasma insulin and rise in GLI observed with somatostatin infusion in intact birds, plasma glucose concentrations were lower than with control saline infusion. [5,14,22] and it has been shown that somatostatin simultaneously inhibits insulin and glucagon secretion; moreover somatostatin appears to be one of the most effective A cell suppressants known [22]. Key words:In birds, it has been shown that the somatostatin producing D cells are particularly numerous in the islets of the pigeon pancreas [20] and very high somatostatin concentrations have been measured in the chicken pancreas [25]. As the duck appears to be an interesting species for studies on pancreatic hormone regulation [17,18] the present study was undertaken to explore the response of pancreatic hormones to somatostatin infusion in ducks. Materials and Methods AnimalsExperiments were performed on male Peking ducks 3 to 6 months old (2 to 2.5 kg), maintained on a normal diet with fowl pellets and tap water ad libitum. HypophysectomyRemoval of the pituitary was performed under local anaesthesia (1% xylocaine, Bellon) according to Benoit's technique [1]. These animals were used for experiments 4 to 10 days after operation. Completeness of hypophysectomy was checked by plasma growth hormone determination. InfusionsAfter an overnight fast the conscious ducks, normal or hypophysectomised, were tied to a board.Somatostatin was dissolved in 0.154 mol/l saline and administered intravenously as a bolus of 800 ng/kg immediately followed by a sustained infusion of 800 ng/kg/min for 30 minutes through a cathether inserted into a leg vein. As controls, normal or hypophysectomised ducks received 0.154 mol/1 saline infusions. Blood SamplingBlood samples were collected from a catheter inserted into a wing vein immediately before infusion (zero time) and at selected intervals thereafter.Blood samples kept on ice were centrifuged at 4 ~ and plasma stored at -20 ~ until the time of assay. Plasma DeterminationsPlasma glucose concentration was measured with a Technicon autoanalyser using a ferricyanide reagent [11] after dialysis of plasma.

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“…A elevação da glicemia é um dos mais evidentes efeitos do glucagon e já foi observado na m aioria dos màmíferos, inclusive no homem (Bondy e Cardillo, 1956;Pincus e R utm an, 1958;Tybergheim, 1961); em aves (Beekman, 1957;Hazeiwood e Lorenz, 1957;Mialhe, 1958) e em répteis (Miller e W urster, 1958;Marques e Riet Corrêa, 1959;H oussay e Penhos, 1960;Miller, 1961); mas, não foi encontrada em Urodelos (M iller e W urster, 1959;W urter e Miller, 1960).…”

Section: Introductionunclassified

Efeitos do Glucagon no metabolismo glicídico de Chrysemys d'orbignyi (Reptilia, Chelonia) sob a influência das variações estacionais

Marques¹

1970

Bol. Inst. Biociênc. Univ. São Paulo, Nova Sér. Zool. Biol. Mar

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Glucagon, Insuline Et Regulation Endocrine De La Glycemie Chez Le Canard

Cited by 36 publications

References 0 publications

Dexamethasone‐induced alterations in glucose tolerance and, insulin, glucagon and adrenaline responses during the first month in white leghorn chicks

Dexamethasone‐induced alterations in glucose tolerance and, insulin, glucagon and adrenaline responses during the first month in white leghorn chicks

Somatostatin stimulates glucagon secretion in ducks

Efeitos do Glucagon no metabolismo glicídico de Chrysemys d'orbignyi (Reptilia, Chelonia) sob a influência das variações estacionais

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