2024
DOI: 10.3389/fendo.2024.1376530
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Glucagon kinetics assessed by mathematical modelling during oral glucose administration in people spanning from normal glucose tolerance to type 2 diabetes

Francesco Andreozzi,
Elettra Mancuso,
Mariangela Rubino
et al.

Abstract: Background/ObjectivesGlucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon variations (especially, glucagon inhibition) to insulin levels (“alpha-cell insulin sensitivity”), during oral glucose administration.Subjects/MethodsWe studied 50 participants (spanning from normal glucose tolerance to type 2 diabetes) undergoing frequently sampled 5-hr oral g… Show more

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