1998
DOI: 10.1210/jcem.83.6.4911
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Glucocorticoid Effects on Bone

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Cited by 36 publications
(13 citation statements)
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“…In fact, generalized wasting of connective tissue is known to occur in Cushing's syndrome (18,38,39). In bone, the long-term exposure of the osteoblasts to glucocorticoids decreases cell proliferation and protein synthesis (18), including type I collagen, osteocalcin, bone sialoprotein, alkaline phosphatase, collagenase and others (18). Reduced collagen synthesis has also been shown in patients with subclinical CS by Sartorio et al (5).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In fact, generalized wasting of connective tissue is known to occur in Cushing's syndrome (18,38,39). In bone, the long-term exposure of the osteoblasts to glucocorticoids decreases cell proliferation and protein synthesis (18), including type I collagen, osteocalcin, bone sialoprotein, alkaline phosphatase, collagenase and others (18). Reduced collagen synthesis has also been shown in patients with subclinical CS by Sartorio et al (5).…”
Section: Discussionmentioning
confidence: 99%
“…Different methods of bone mass evaluation are currently adopted, and dual-energy X-ray absorptiometry (DEXA) is considered the gold standard for BMD measurement in patients with steroid excess (18). However, ultrasound instruments using attenuation and/or velocity propagation determinations, not based on radioactive sources or ionizing radiation, have been developed as a screening test for subjects at high risk of osteoporosis (19,20).…”
Section: Introductionmentioning
confidence: 99%
“…Cortisol exerts direct and indirect effects on bone, enhancing its resorption first and then inhibiting its formation (9)(10)(11)(12)(13). Direct effects of glucocorticoid excess include inhibited differentiation of pluripotent mesenchymal cells toward the osteoblastic lineage and enhancement of their differentiation into the adipocytic pathway (13).…”
Section: Introductionmentioning
confidence: 99%
“…Further negative effects of cortisol excess on bone consist of its inhibition of the gonadal axis function in both genders (11,12). It is important to consider, however, that androgen production is increased in adrenocorticotropin (ACTH)-dependent and in some adrenal-dependent hypercortisolism.…”
Section: Introductionmentioning
confidence: 99%
“…Urinary biochemical bone resorption markers adjusted by urinary Cr were either normal (29 -32) or increased (33,34). Because urinary Cr excretion is primarily a function of muscle mass, and protein synthesis and lean muscle mass are substantially reduced in subjects taking corticosteroids (35), it is possible that much of the apparent increase in bone resorption marker reported in previous studies (33,34) is a function of reduced Cr excretion (36). We used body weight to standardize urinary NTx in the present study.…”
Section: Three Dex Treatment Regimens In Pigletsmentioning
confidence: 91%