Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment

Gupta, Anu; Gupta, Yashdeep

doi:10.4103/2230-8210.117215

Cited by 146 publications

(106 citation statements)

References 16 publications

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“…The use of corticosteroids is one of the factors associated with impaired muscle strength [75][76][77]. However, in our study only one patient in the fatigue group used corticosteroids at the time of participation.…”

Section: Discussionmentioning

confidence: 57%

Physical fitness and physical activity in fatigued and non-fatigued inflammatory bowel disease patients

Vogelaar¹,

Berg-Emons²,

Bussmann³

et al. 2015

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 57%

Physical fitness and physical activity in fatigued and non-fatigued inflammatory bowel disease patients

Vogelaar¹,

Berg-Emons²,

Bussmann³

et al. 2015

Scandinavian Journal of Gastroenterology

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“…Glucocorticoids have been found to induce muscle atrophy and alter muscle function 20 . Beta-blockade has been found to decrease maximal exercise capacity 21 .…”

Section: Methodsmentioning

confidence: 99%

Frailty and maximal exercise capacity in adult lung transplant candidates

Layton

Armstrong

Baldwin

et al. 2017

Respiratory Medicine

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Background Frail lung transplant candidates are more likely to be delisted or die without receiving a transplant. Further knowledge of what frailty represents in this population will assist in developing interventions to prevent frailty from developing. We set out to determine whether frail lung transplant candidates have reduced exercise capacity independent of disease severity and diagnosis. Methods Sixty-eight adult lung transplant candidates underwent cardiopulmonary exercise testing (CPET) and a frailty assessment (Fried’s Frailty Phenotype (FFP)). Primary outcomes were peak workload and peak aerobic capacity ( trueV˙normalO2). We used linear regression to adjust for age, gender, diagnosis, and lung allocation score (LAS). Results The mean ± SD age was 57 ± 11 years, 51% were women, 57% had interstitial lung disease, 32% had chronic obstructive pulmonary disease, 11% had cystic fibrosis, and the mean LAS was 40.2 (range 19.2 to 94.5). In adjusted models, peak workload decreased by 10 watts (95% CI 4.7 to 14.6) and peak trueV˙normalO2 decreased by 1.8 ml/kg/min (95% CI 0.6 to 2.9) per 1 unit increment in FFP score. After adjustment, exercise tolerance was 38 watts lower (95% CI 18.4 to 58.1) and peak trueV˙normalO2 was 8.5 ml/kg/min lower (95% CI 3.3 to 13.7) among frail participants compared to non-frail participants. Frailty accounted for 16% of the variance (R2) of watts and 19% of the variance of trueV˙normalO2 in adjusted models. Conclusion Frailty contributes to reduced exercise capacity among lung transplant candidates independent of disease severity.

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“…Patients may describe difficulty arising from a seated position and climbing stairs. Less commonly distal muscles and even respiratory muscles can be affected [16,17]. Serum muscle enzymes are typically normal and electromyography may demonstrate myopathic findings [17].…”

Section: Steroid-induced Myopathymentioning

confidence: 99%

“…Less commonly distal muscles and even respiratory muscles can be affected [16,17]. Serum muscle enzymes are typically normal and electromyography may demonstrate myopathic findings [17]. & Steroid myopathy has a significant impact on patients' quality of life [15].…”

Section: Steroid-induced Myopathymentioning

confidence: 99%

Managing Disease and Therapy-Related Complications in Patients with Central Nervous System Tumors

Raizer¹,

Dixit

2015

Curr. Treat. Options in Oncol.

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Treating patients with brain tumors can be divided into tumor-directed therapies, the management of tumor-related symptoms and complications and the psychosocial aspect of patient care. In this review, we will discuss the management of disease and treatment-related complications, which can negatively impact patient quality of life and functional status. Brain edema is a common complication or brain tumors and often causes more symptoms than the tumor itself. Treatment options are limited to the use of corticosteroids, which although effective have a plethora of side effects, so the goal should be the lowest dose that maximizes symptoms. Seizures are more common in lower grade brain tumors and treatment should be limited to patients who have seizures using agents that do not affect the metabolism of other drugs, especially chemotherapies. Blood clots are also common in patients and although there is a "fear" of tumoral bleeding, this is not a frequent occurrence; hence, using anticoagulants should be routinely used in patients who experience this complication.

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Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment

Cited by 146 publications

References 16 publications

Physical fitness and physical activity in fatigued and non-fatigued inflammatory bowel disease patients

Physical fitness and physical activity in fatigued and non-fatigued inflammatory bowel disease patients

Frailty and maximal exercise capacity in adult lung transplant candidates

Managing Disease and Therapy-Related Complications in Patients with Central Nervous System Tumors

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