2009
DOI: 10.1073/pnas.0808716106
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Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress

Abstract: Stress elicits a synchronized response of the endocrine, sympathetic, and central nervous systems to preserve homeostasis and well-being. Glucagon-like peptide-1 (GLP-1), a primary posttranslational product of the preproglucagon (PPG) gene, activates both physical and psychological stress responses. The current study examined mechanisms regulating expression of PPG gene products in the hindbrain. Our results indicate that PPG mRNA decreases rapidly after exposure to acute stressors of multiple modalities. Redu… Show more

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Cited by 56 publications
(55 citation statements)
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“…The morning following FST, rats were rapidly decapitated (Zhang et al, 2009). Brains were removed and fast-frozen by immersion in isopentane on dry ice (−45C) and stored at −80C.…”
Section: Methodsmentioning
confidence: 99%
“…The morning following FST, rats were rapidly decapitated (Zhang et al, 2009). Brains were removed and fast-frozen by immersion in isopentane on dry ice (−45C) and stored at −80C.…”
Section: Methodsmentioning
confidence: 99%
“…24,25 In turn, physiological stressors as well as glucocorticoids themselves modulate GCG transcription in the hindbrain. 26 Furthermore, centrally administered exendin 4 engages the sympathetic nervous system in rats, including medullary catecholamine neurons and the adrenal medulla. 27 In rodents, sympathetic nervous system activity is necessary for several central GLP1R-mediated effects, including inhibition of gastric emptying, adipogenesis inhibition and exendin 4-induced hyperglycemia.…”
Section: Central Glp-1 and Energy Balancementioning
confidence: 99%
“…The NTS sends excitatory, primarily noradrenergic, projections to CRH neurons (48,250,293) suggesting that GR action in NTS may contribute to, or modulate, feedback effects of corticosteroids. Recent studies in the Herman lab suggest that stress-induced corticosterone rapidly downregulates neuropeptide glucagon-like peptide 1 expression in NTS (323). The GLP-1 expressing neurons contain GR (104,250) and project to the PVN, synapsing on CRH neurons (289).…”
Section: Mechanisms Of Delayed Feedback: Role Of Brainstemmentioning
confidence: 99%