Glucocorticoid use in patients with preterm premature rupture of the fetal membranes

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

“…For the mother, corticosteroid use was not shown to increase the risk of death, chorioamnionitis or puerperal sepsis (Roberts 2006). Contrary to the concern that corticosteroid treatment may increase infection in those with preterm prelabour rupture of membranes (Imseis 1996) or increase the rate of stillbirth in those with pregnancy-related hypertension (Liggins 1976), this Cochrane review confirmed that antenatal corticosteroid treatment is effective in women at risk of preterm birth with these complications (Roberts 2006). Corticosteroids have become the standard of care for women at risk of preterm birth before 32 to 34 weeks’ gestation in many countries (Jobe 2004; NIH 1995).…”

Preterm Premature Rupture of Membranes: Perspectives Surrounding Controversies in Management

“…Although the conclusions of the NIH panel have been supported by a more formal decision analysis, 59 other authors have voiced concerns about corticosteroid administration in PPROM. 60 The lack of enthusiastic support for the use of corticosteroids primarily centers on the potential for increased risk of infectious morbidities such as chorioamnionitis, postpartum endometritis, and neonatal sepsis. To this end, two recent studies 61,62 and a meta-analysis 63 have been published that support the use of a single course of corticosteroids to patients with PPROM.…”