Glucocorticoids and the risk of osteoporosis

Vitamin D Deficiency and Reduced Lung Function in Connective Tissue-Associated Interstitial Lung Diseases

“…[17][18][19][20] Corticosteroids are a mainstay of treatment regimens in patients with CTD-ILD, 21,22 and the detrimental effects of long-term usage on bone health are well documented. 23 In SLE, vitamin D insuffi ciency was associated with cumulative corticosteroid exposure, 24 and the interplay of chronic infl ammation and low vitamin D levels has been causally implicated in low bone mineral density in these patients. 25 In subjects with asthma, it has recently been reported that reduced vitamin D levels are associated with impaired steroid responsiveness.…”

Tenofovir-associated bone density loss

“…Osteoporosis commonly occurs in women following menopause, where it is called postmenopausal osteoporosis, but can also occur in men or anyone with certain hormonal disorders, other chronic diseases, or due to medications such as glucocorticoids. [17][18][19][20][21][22][23] Vitamin D deficiencies can result in bone softening, resulting in osteomalacia -in children called rickets. [24][25][26] Loss of osteoclast function increases bone density, resulting in osteopetrosis.…”

Steroids in neurooncology: actions, indications, side-effects

“…Long-term administration of glucocorticoids is frequently associated with osteoporosis which results in significant morbidity and mortality [70,71]. The underlying pathophysiological mechanisms include the induction of apoptosis in osteoblasts and osteocytes [72] Special attention should also be given to individuals using medications that increase the risk of falling including antihypertensives, some anticonvulsants and benzodiazepines [74].…”