Glucocorticoids in the regulation of transcription factors that control cytokine synthesis

Liberman, Ana C.; Druker, Jimena; Perone, Marcelo J.; Arzt, Eduardo

doi:10.1016/j.cytogfr.2007.01.005

Cited by 108 publications

(93 citation statements)

References 94 publications

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“…Todo el espectro de albos moleculares explica tanto la pleiotropía como la fuerza antiinflamatoria e inmunomoduladora. Es por eso que al bloquear la síntesis de la citocina IL-5 y el factor estimulante de colonias de granulocitos y macrófagos (GM-CSF), se desencadena la muerte programada de estas células (apoptosis), lo que disminuye la vida media de los eosinófilo, una vez que esta citocina (IL-5) se encarga de la eosinófilopoyesis, causando el aumento de la función de los eosinófilos maduros, así como la degranulación, adherencia y citotoxicidad, prolongando así la sobrevivencia de esa célula (30).…”

Section: Discussionunclassified

“…This is why blocking the synthesis of IL-5 cytokine and granulocyte-macrophage colonystimulating factors (GM-CSF) triggers the programmed death of these cells (apoptosis), which decreases the half-life of eosinophil, since cytokine (IL-5) is responsible for eosinophilopoiesis, increasing the function of mature eosinophils as well as degranulation, adhesion and cytotoxicity, thus prolonging the survival of that cell (30).…”

Section: Discussionmentioning

confidence: 99%

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Pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Parte 1. Caracterización clínica

2016

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Objective. The objective of the present study was to characterizer clinically of the healing process of cutaneous pythiosis in horses treated with triamcinolone acetonide. Materials and methods. We conducted a descriptive study, not probabilistic, of convenience. 24 horses were used with cutaneous pythiosis confirmed, a group of 12 animals was administered 50 mg of intramuscular injection of triamcinolone acetonide (TG) and the other group was not applied any treatment (CG). They are undergoing clinical and microscopic characterization of the lesion every 4 days until the complete recovery of granuloma in the GT. Being verified decreased fibrin bloody exudate, pruritus, presence of fistulae and output kunkers, likewise radiographic projections were performed to assess the degree of compromise bone and tissue fibrosis. Results. Macroscopically animals GT present progressive decrease in the clinical features of the disease at 16±1.4 days post treatment application. The wound contraction was 100% at 60±3.4 days after application of the treatment in all granulomas of GT, being highly significant (p<0.0001). Radiological monitoring of chronic skin lesions, met invasion to underlying tissues compromising bone structures, characterized by tissue fibrosis, moderate exostosis, bake as osteolysis and osteomyelitis. Neither of the animals in the CG showed improvement in clinical characteristics, and macroscopic of pythiosis and maintained equal to the first day throughout the study. Conclusions. The use of triamcinolone acetonide is a good therapeutic alternative for the treatment of granulomatous Pythiosis wounds in horses with 100% clinical recovery.Keywords: Pythium insidiosum, oomicosis, Kunkers, granuloma (Source: MeSh). RESUMENObjetivo. El objetivo del estudio fue caracterizar clínicamente el proceso de cicatrización de la pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Materiales y métodos. Se realizó un estudio descriptivo, no probabilístico, de conveniencia. Fueron utilizados 24 equinos con pythiosis cutánea. A un grupo le fue aplicado 50 mg de acetonida de triamcinolona vía intramuscular (GT) y al otro grupo no fue aplicado tratamiento (GC). Se realizó caracterización clínica y macroscópica de la lesión cada 4 días hasta la recuperación completa del granuloma en el GT. Siendo verificada la disminución del 5512REVISTA MVZ CÓRDOBA • Volumen 21(3) Septiembre -Diciembre 2016 exudado fibrinosanguinolento, prurito, presencia de trayectos fistulosos y salida de kunkers, también, fueron realizadas proyecciones radiológicas para evaluar el grado de compromiso óseo y fibrosis tecidual. Resultados. Macroscópicamente, los animales del GT presentaron diminución progresiva en las características clínicas de la enfermedad a los 16±1,4 días post aplicación del tratamiento. La contracción de la herida fue del 100% a los 60±3.4 días post aplicación del tratamiento en todos los granulomas del GT, siendo altamente significativa (p<0.0001). Radiológicamente, se encontró invasión a los tejidos subyacente...

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Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

Pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Parte 1. Caracterización clínica

2016

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“…The repression of NF-κβ will finally inhibit the expression of some cytokines as TNF-α, IL-1, IL-8 (interleukin-8) and ICAM-1 17 . Transrepression between GCs and TFs is reciprocal, and NF-κβ 17 can also repress glucocorticoid receptors; which could, at least in part, induce GC resistance in some patients.…”

Section: Introductionmentioning

confidence: 99%

“…However, the success rate of topical GC ranges from 60.9 to 80% 12,13,16 . The anti-inflammatory property of GCs occurs due to their binding to the glucocorticoid receptor (GR); the GC-GR complex inhibits other TF, such as NF-κβ, a phenomenon known as transrepression 4,[17][18][19] . The repression of NF-κβ will finally inhibit the expression of some cytokines as TNF-α, IL-1, IL-8 (interleukin-8) and ICAM-1 17 .…”

Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory property of GCs occurs due to their binding to the glucocorticoid receptor (GR); the GC-GR complex inhibits other TF, such as NF-κβ, a phenomenon known as transrepression 4,[17][18][19] . The repression of NF-κβ will finally inhibit the expression of some cytokines as TNF-α, IL-1, IL-8 (interleukin-8) and ICAM-1 17 . Transrepression between GCs and TFs is reciprocal, and NF-κβ 17 can also repress glucocorticoid receptors; which could, at least in part, induce GC resistance in some patients.…”

Section: Introductionmentioning

confidence: 99%

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In vitro effect of glucocorticoids on nasal polyps

Valera¹,

Brassesco²,

Castro‐Gamero³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Glucocorticoids are considered the main treatment option for nasal polyps, but their effect is only recently being understood. Aim To evaluate whether fluticasone propionate (FP) inhibits the inflammatory process induced by TNF-alpha in vitro , and to assess if NF-kappaB is associated to this inhibition. Study Design Experimental in vitro study. Materials and Methods Nasal polyp fibroblasts were cultured during 24 hours. Three different concentrations of FP (1, 10 and 100 nM, added to TNF-alpha) were compared to negative (without additive) and positive (TNF-alpha) controls. Gene expression (RTQ-PCR) and protein concentration (ELISA) of VCAM-1, ICAM-1, eotaxin and RANTES were measured, as well as the nuclear translocation of NF-kappaB. Results TNF-alpha significantly increased protein concentration and RNA expression of all the studied molecules, as well as the nuclear translocation of NF-kappaB, when compared to the negative control. FP decreased these parameters in a dose-dependent manner, statistically different from positive control up to 100nM. Conclusions FP extensively inhibited inflammatory recruiters, at both protein and RNA levels, confirming the ability of glucocorticoids to modulate the inflammatory process in nasal polyps. This inhibition was associated to decreased NF-kappaB nuclear translocation, demonstrating that this is an important mechanism of glucocorticoids action for nasal polyps.

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