Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter

Ivy,; Oosthuyzen, Wilna; Peltz, Theresa S.; Howarth, Amelia R.; Hunter, Robert W.; Dhaun, Neeraj; Al-Dujaili, Emad A S; Webb, David J.; Dear, James W.; Flatman, Peter W.; Bailey, Matthew A.

doi:10.1161/hypertensionaha.115.06977

Cited by 62 publications

(61 citation statements)

References 45 publications

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“…This is also proven by the fact that beta-adrenoreceptor stimulation significantly participates in glucocorticoid excess-induced metabolic and gravimetric alterations (Kis et al, 2001;Kis and Crăciun, 2003 a, b). This experimental result is consistent with other similar research results, according to which the high amount of glucocorticoid is harmful, resulting in increased blood pressure (Hunter et al, 2016;Ivy et al, 2016;Jeje and Raji, 2017). In longterm treatment with glucocorticoids, increased blood pressure in the heart and vascular a b system disease can occur which change kidney function.…”

Section: Histological Studies Of the Kidney In The Control And Treatesupporting

confidence: 92%

“…Chronic corticosterone infusion increased bmal1, per1, sgk1, and tsc22d3 genes expression during the inactive phase. In the inactive phase pNCC was also elevated by corticosterone (Ivy et al, 2016).…”

Section: Introductionmentioning

confidence: 90%

“…The excess of glucocorticoids increases in the liver the storage of glycogen obstructs the movement of glycogen in the blood and it stimulates the gluconeogenesis (Nyirenda et al, 2000;Hans et al, 2006;Waldron et al, 2013;Ivy et al, 2016). Glucocorticoids inhibit the uptake and usage of sugar in the muscle and adipose tissues (Grigoriadis et al, 1988;Burén et al, 2002;Lundgren et al, 2004;Gounarides et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Has the Fluocinolon-acetonid N ointment any effect on the kidneys and the thyroid gland structure and function?

Kis¹,

András²

2017

Studia UBB Biologia

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SUMMARY.Besides the naturally occurring glucocorticoids, there are many other synthetically produced glucocorticoids: dexamethasone, prednisolone, triamcinolone, triamcinolone acetonide, flumetazon, methyl prednisone and methylprednisolone. Corticosteroids are administered intravenously, orally, through inhalation directly onto the inflamed organ, eye drops and by applying skin ointments. Although long term use has its undesirable effects, e.g. high blood pressure, heart failure, diabetes and renal failure. Fluocinolon-acetonid N ointment is a synthetic derivate of the adrenocortical hormone, which is used for medical treatment purposes in dermatology. We also use it in our homes, mostly due to its anti-inflammatory effect, in the treatment of itching, and also in the acute keratosis. It is highly effective in serious, non contagious, dry skin inflammations, such as atopic eczema, seborrheic dermatitis, psoriasis, dermatitis or even in allergic reactions. In prolonged usage due to its liposoluble properties, it is easily absorbed into the bloodstream, which increases the chances of having side effects. The main objective of this study is to analyze the side effects of glucocorticoid excess when treatment is done with Fluocinolon-acetonid N ointment, to see if it has any effect on organs which have an important role in maintaining basal metabolism such as kidneys and thyroid gland. Our results demonstrate that fluocinolon treatment affects the structure and the function of kidneys and thyroid gland.

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Section: Histological Studies Of the Kidney In The Control And Treatesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Has the Fluocinolon-acetonid N ointment any effect on the kidneys and the thyroid gland structure and function?

Kis¹,

András²

2017

Studia UBB Biologia

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“…However, when examining NCC activation through phosphorylation (pNCC) by the WNK-OSR1/SPAK pathway [58], there appears to be a significant night/day difference in pNCC protein expression, with a peak at the beginning of the active period and a nadir at the start of the inactive period [57]. This night/day difference in pNCC expression was seen in another study as well [59]. Richards et al showed evidence that Per1 facilitates the expression of NCC through the WNK pathway, as reducing the expression of the clock protein resulted in a reduction of NCC, WNK1 and WNK4 as well [60].…”

Section: Circadian Rhythms Along the Nephronmentioning

confidence: 97%

“…This regulation of the circadian variation of plasma GC is controlled by the SCN through neural and humoral signals [111], however little is known about the effects of GC on circadian function in the kidney. A study by Ivy et al found that chronic corticosterone infusion led to increased levels of pNCC, Bmal1 and Per1 during the inactive phase, and a non-dipping BP phenotype [59]. Treatment of these mice with hydrochlorothiazide reversed the non-dipping phenotype back to normal [59].…”

Section: Integration Of Circadian Control Throughout the Nephronmentioning

confidence: 99%

Circadian regulation of renal function

Johnston

Pollock

2018

Free Radical Biology and Medicine

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The kidneys regulate many vital functions that require precise control throughout the day. These functions, such as maintaining sodium balance or regulating arterial pressure, rely on an intrinsic clock mechanism that was commonly believed to be controlled by the central nervous system. Mounting evidence in recent years has unveiled previously underappreciated depth of influence by circadian rhythms and clock genes on renal function, at the molecular and physiological level, independent of other external factors. The impact of circadian rhythms in the kidney also affects individuals from a clinical standpoint, as the loss of rhythmic activity or clock gene expression have been documented in various cardiovascular diseases. Fortunately, the prognostic value of examining circadian rhythms may prove useful in determining the progression of a kidney-related disease, and chronotherapy is a clinical intervention that requires consideration of circadian and diurnal rhythms in the kidney. In this review, we discuss evidence of circadian regulation in the kidney from basic and clinical research in order to provide a foundation on which a great deal of future research is needed to expand our understanding of circadian relevant biology.

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Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Crislip

Johnston

Douma

et al. 2021

Comprehensive Physiology

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Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mechanisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskeletal, immune, and central nervous systems are discussed.

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Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter

Abstract: Supplemental Digital Content is available in the text.

Cited by 62 publications

References 45 publications

Has the Fluocinolon-acetonid N ointment any effect on the kidneys and the thyroid gland structure and function?

Has the Fluocinolon-acetonid N ointment any effect on the kidneys and the thyroid gland structure and function?

Circadian regulation of renal function

Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

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