Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism

Scholz-Ahrens, Katharina Elisabeth; Delling, G.; Stampa, B.; Helfenstein, Andreas; Hahne, H.‐J.; Açil, Yahya; Timm, Wolfram; Barkmann, Rainer; Hassenpflug, J.; Schrezenmeir, Jürgen; Glüer, Claus-Christian

doi:10.1152/ajpendo.00627.2006

Cited by 35 publications

(37 citation statements)

References 64 publications

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“…Recently, it has been reported that 10 mg/kg body weight prednisolone for 10 days decreases rat intestinal Ca 2+ absorption through diminished expression of the active calcium transporters such as the channel TRPV6 and CB 9k , independently of 1,25(OH) 2 D 3 [80]. A similar finding was also reported by Scholz-Ahrens et al [81]. These authors used adult Göttingen miniature pigs treated orally with prednisolone at a dose of 1 mg·kg body weight –1 · day –1 for 8 weeks (short-term) and thereafter at 0.5 mg·kg body weight –1 ·day –1 (long-term).…”

Section: Regulation By Other Hormonessupporting

confidence: 59%

“…By looking at the parallel decline in calcium balance and BMD and the parallel lower bone ash content, the authors concluded that GC-induced osteoporosis was the consequence of reduced intestinal mineral absorption. Scholz-Ahrens et al [81] think that GCs may directly alter the vitamin D-independent transmucosal absorption of calcium because they did not find large effects on plasma vitamin D metabolites or on PTH. Their conclusion is that alterations in vitamin D metabolites associated with the GC-induced osteoporosis might be the consequence of preexistent disorders.…”

Section: Regulation By Other Hormonesmentioning

confidence: 99%

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Minireview on Regulation of Intestinal Calcium Absorption

Pérez¹,

Picotto²,

Carpentieri

et al. 2008

Digestion

132

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An overview of current information on the mechanisms by which intestinal calcium absorption occurs is described in this article. Both paracellular and transcellular pathways are analyzed. Special emphasis focuses on molecules participating in the latter pathway, such as TRPV5 and TRPV6 channels, located in the apical region of the enterocytes, CB_9k and CB_28k, presumably involved in the cation movement from the apical to the basolateral pole of the cell, and PMCA_1b and Na⁺/Ca²⁺ exchanger, proteins that extrude Ca²⁺ from the cells. Current concepts on the relative importance of paracellular and transcellular calcium transport and the vitamin D dependence of each pathway are referred and analyzed showing the contrasting views on this issue. More detailed information is given regarding the stimulatory effect of vitamin D on intestinal Ca²⁺ absorption either in animal models or in the human intestine. The possible mechanisms triggered by hormones such as PTH, calcitonin, estrogen, thyroid hormone, glucocorticoids and different nutritional factors on intestinal calcium absorption are also reviewed. Finally, the influence of physiological conditions such as growth, pregnancy, lactation and aging on intestinal calcium absorption are discussed.

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Section: Regulation By Other Hormonessupporting

confidence: 59%

Section: Regulation By Other Hormonesmentioning

confidence: 99%

Minireview on Regulation of Intestinal Calcium Absorption

Pérez¹,

Picotto²,

Carpentieri

et al. 2008

Digestion

132

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“…In addition, the expression of genes expressed in osteocytes associated with bone mineralization (Dmp1 and Phex) was significantly higher at the later time points [97]. Others' animal models in GIOP have been reported: beagles [98], ewes [99], rabbits [100], pigs [101][102][103], and zebrafish [104] (Table 5).…”

Section: Experimental Models Of Giopmentioning

confidence: 92%

Glucocorticoid-Induced Osteoporosis: A Review

Bouvard

Legrand

Audran

et al. 2009

Clinic Rev Bone Miner Metab

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Glucocorticoid (GC)-induced osteoporosis is the main cause of secondary osteoporosis. Fractures, which are often asymptomatic, can occur in as many as 50% of patients receiving chronic GC therapy. GCs have direct and indirect effects on bone cells (osteoblasts, osteocytes, and osteoclasts) with a suppression of bone formation and an increased bone resorption. The management of patients exposed to GCs should include the use of the minimal effective dose of GC, general health measures, and adequate intakes of calcium and vitamin D. Bisphosphonates are nowadays largely used in GC-induced osteoporosis and teriparatide has proved its efficiency as well.

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“…The application of glucocorticoids in minipigs has been shown to induce reduction of BMD in the lumbar spine as assessed by quantitative computed tomography (QCT; Scholz-Ahrens et al, 2007). QCT enables repeated measurements of the entire skeleton over time and is therefore suitable for large animal studies on bone structure.…”

Section: Introductionmentioning

confidence: 99%

Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs

et al. 2017

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Osteoporosis is a systemic bone disease with an increasing prevalence in the elderly population. There is conflicting opinion about whether osteoporosis affects the alveolar bone of the jaws and whether it poses a risk to the osseointegration of dental implants. The aim of the present study was to evaluate the effects of systemic glucocorticoid administration on the jaw bone density of minipigs. Thirty-seven adult female minipigs were randomly divided into two groups. Quantitative computed tomography (QCT) was used to assess bone mineral density BMD of the lumbar spine as well as the mandible and maxilla, and blood was drawn. One group of minipigs initially received 1.0 mg prednisolone per kg body weight daily for 2 months. The dose was tapered to 0.5 mg per kg body weight per day thereafter. The animals in the other group served as controls and received placebo. QCT and blood analysis were repeated after 6 and 9 months. BMD was compared between the two groups by measuring Hounsfield units, and serum levels of several bone metabolic markers were also assessed. A decrease in BMD was observed in the jaws from baseline to 9 months. This was more pronounced in the prednisolone group. Statistically significant differences were reached for the mandible (p < 0.001) and the maxilla (p < 0.001). The administration of glucocorticoids reduced the BMD in the jaws of minipigs. The described model shows promise in the evaluation of osseointegration of dental implants in bone that is compromised by osteoporosis.

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Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism

Abstract: Glü er C-C. Glucocorticosteroid-induced osteoporosis in adult primiparous Gö ttingen miniature pigs: effects on bone mineral and mineral metabolism.

Cited by 35 publications

References 64 publications

Minireview on Regulation of Intestinal Calcium Absorption

Minireview on Regulation of Intestinal Calcium Absorption

Glucocorticoid-Induced Osteoporosis: A Review

Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs

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