Glucomannans Alleviated the Progression of Diabetic Kidney Disease by Improving Kidney Metabolic Disturbance

Chen, Haihong; Nie, Qixing; Hu, Jielun; Huang, Xiao‐Jun; Zhang, Ke; Nie, Shaoping

doi:10.1002/mnfr.201801008

Cited by 29 publications

(40 citation statements)

References 62 publications

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“…Guar gum, carrageenan, apple pectin, xylan, arabinogalactan, and xanthan gum were purchased from Sigma-Aldrich (St. Louis, MO, USA). Glucomannan, β-glucan, and arabinoxylan were prepared from barley, konjac, and seed of Plantago asiatica L using the method described in previous studies. − The seeds of P. asiatica L were purchased from Ji’an, Jiangxi Province, China.…”

Section: Methodsmentioning

confidence: 99%

Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Nie

et al. 2021

J. Agric. Food Chem.

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High intake of dietary fibers was found to be inversely associated with type-2 diabetes (T2D), whereas the difference among different dietary fibers on T2D remains unclear. Therefore, we have investigated the effects of different dietary fibers on T2D. Nine types of dietary fibers were used to investigate and evaluate their effects on type-2 diabetic rats via physiology, genomics, and metabolomics. We found that supplementation with β-glucan, arabinogalactan, guar gum, apple pectin, glucomannan, and arabinoxylan significantly reduced the fasting blood glucose, whereas carrageenan, xylan, and xanthan gum did not affect glycemic control in diabetic rats. Also, bioactive dietary fibers (β-glucan, arabinogalactan, guar gum, and apple pectin) associated with the increased butyric acid level and abundance of beneficial bacteria (Lachnobacterium, Parabacteroides, Faecalibacterium, Akkermansia, and some butyric acid-producing bacteria), as well as improved host metabolism by decreasing 12α-hydroxylated bile acids, acylcarnitines, and amino acids (leucine, phenylalanine, citrulline, etc.), thereby exert beneficial effects on T2D. It was also found that β-glucan might attenuate insulin resistance via downregulation of Prevotella copri-mediated biosynthesis of branched-chain amino acids in T2D. Together, our study uncovered the effects of different dietary fibers on T2D, along with their potential mechanism.

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Section: Methodsmentioning

confidence: 99%

Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Nie

et al. 2021

J. Agric. Food Chem.

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“…Dendrobium is a genus of valuable medicinal herbs in the family Orchidacea [1], containing 74 species and two varieties in China [2] of which many species can be used as medicine [3,4]. Dendrobium officinale is a precious species and famously known as one of the nine immortal herbs [5], as it possesses many kinds of physiological functions [6], including immune modulation [7], antitumor activity [8], and helping to reduce levels of blood glucose [9,10]. However, wild D. officinale is scarce because it requires a peculiar growth environment and takes a long time to grow.…”

Section: Introductionmentioning

confidence: 99%

Comparative Metabolomic Analysis of Dendrobium officinale under Different Cultivation Substrates

Zuo

Zhang

et al. 2020

Metabolites

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Dendrobium officinale, a precious herbal medicine, has been used for a long time in Chinese history. The metabolites of D. officinale, regarded as its effective components to fight diseases, are significantly affected by cultivation substrates. In this study, ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS) was conducted to analyze D. officinale stems cultured in three different substrates: pine bark (PB), coconut coir (CC), and a pine bark: coconut coir 1:1 mix (PC). A total of 529 metabolites were identified. Multivariate statistical analysis methods were employed to analyze the difference in the content of metabolites extracted from different groups. By the criteria of variable importance in projection (VIP) value ≥1 and absolute log2 (fold change) ≥1, there were a total of 68, 51, and 57 metabolites, with significant differences in content across groups being filtrated out between PB and PC, PB and CC, and PC and CC, respectively. The comparisons among the three groups revealed that flavonoids were the metabolites that fluctuated most. The results suggested the D. officinale stems from the PB group possessed a higher flavonoid content. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that the significantly regulated metabolites were mainly connected with flavonoid biosynthesis. A comprehensive profile of the metabolic differentiation of D. officinale planted in different substrates was provided, which supports the selection of an optimum cultivation substrate for a higher biomass yield of D. officinale.

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“…The animal and experimental design was described in our previous study. 17 In brief, all animals were individually housed in cages with a controlled temperature, relative humidity, and 12/12 h light/dark cycle. After acclimation for 1 week, all of the animals were assigned to two groups.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Multiomics Approach to Explore the Amelioration Mechanisms of Glucomannans on the Metabolic Disorder of Type 2 Diabetic Rats

Chen

Nie

et al. 2021

J. Agric. Food Chem.

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Type 2 diabetes (T2D) is a worldwide epidemic associated with metabolic disorders and intestinal microbiota alterations. Polysaccharides have been considered to be beneficial to the prevention and alleviation of T2D. In the present study, ultra-performance liquid chromatography−triple-time-of-flight-based metabolomics and proteomics and 16S rRNA sequencing methods were employed to evaluate the effects of glucomannans from Dendrobium officinale stem, konjac, and Aloe vera leaves on host metabolism and intestinal microbiota regulation in type 2 diabetic rats and potential mechanisms. The metabolism of amino acids was significantly disturbed in the type 2 diabetic rats, especially the upregulated branched-chain amino acid (BCAA) metabolism. Host-derived BCAA metabolism was significantly decreased in type 2 diabetic rats. However, the levels of BCAAs in host circulation and gene abundance of BCAA biosynthesis in gut microbiota were significantly increased in diabetic rats, which suggested that the disturbed intestinal microbiota might be responsible for the increased circulation of BCAAs in T2D. Glucomannan treatment decreased the abundance of microbial BCAA biosynthesis-related genes and ameliorated the host BCAA metabolism. Also, glucomannan with a higher molecular weight and a lower ratio of mannose/glucose possessed better antidiabetic effects. In summary, the antidiabetic effects of glucomannans might be associated with the amelioration of BCAA metabolism by modulating intestinal microbiota.

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Glucomannans Alleviated the Progression of Diabetic Kidney Disease by Improving Kidney Metabolic Disturbance

Cited by 29 publications

References 62 publications

Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Comparative Metabolomic Analysis of Dendrobium officinale under Different Cultivation Substrates

Multiomics Approach to Explore the Amelioration Mechanisms of Glucomannans on the Metabolic Disorder of Type 2 Diabetic Rats

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