GlucoMen Day Continuous Glucose Monitoring System: A Screening for Enzymatic and Electrochemical Interferents

Lucarelli, Fausto; Ricci, Francesco; Caprio, Felice; Valgimigli, Francesco; Scuffi, Cosimo; Moscone, Danila; Palleschi, Giuseppe

doi:10.1177/193229681200600522

Cited by 35 publications

(24 citation statements)

References 16 publications

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“…51 CGM readings may be inaccurate during periods of high glycemic variability, as well as after ingestion of acetaminophen or ascorbic acid. 52,53 Recent guidelines recommend clinicians consider using daily CGM in essentially all adult patients with type 1 diabetes, and intermittent CGM in any adult patient with diabetes and suspected nocturnal hypoglycemia, dawn phenomenon, postprandial hyperglycemia, hypoglycemic unawareness, or when significant therapeutic changes are made such as initiating or intensifying insulin. 54 Insurance plans reimburse charges for insertion and interpretation, particularly in patients with type 1 diabetes and in patients with type 2 diabetes treated with insulin.…”

Section: Alternatives To Using A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

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Section: Alternatives To Using A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

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“…[5][6][7][8][9][10][11] The latter microdialysis technique, as described in detail by Feichtner et al,7 has also been used by us in combination with infrared spectroscopy for ex-vivo glucose quantification. 12,13 Recently, an overview for continuous glucose monitoring (CGM) systems, based on electrochemical sensing as utilised in needle-type sensors directly implanted and micro-dialysis based systems for interstitial fluid or intravascular application with ex-vivo detection, has been given by Lucarelli et al 14 . These authors are reporting especially on enzymatic and electrochemical interferents, which comprise in particular endogenous and exogenous chemicals including non-glucose sugars.…”

Section: Introductionmentioning

confidence: 99%

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry

et al. 2015

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Micro-dialysis has been established in the clinical environment for continuously harvesting body fluids, but a drawback of this process are variable recovery rates, which can be observed especially for subcutaneously implanted catheters. Perfusates with either acetate or mannitol have been investigated as recovery markers. The latter substance is suggested for application with external cavity tuneable quantum cascade lasers, rendering a limited wavenumber interval in contrast to FTIR-spectrometers. Despite the overlap of mannitol and glucose spectra, their simultaneous quantification was successful. By investigating the depletion of the marker substances from the perfusates using different micro-dialysis devices, the theoretical nonlinear relationship between the relative dialysate marker concentration and glucose recovery rate was confirmed for the marker substance-analyte pair of acetate and glucose, rendering a basis for reliable blood glucose measurements. For the pair of mannitol and glucose an almost linear dependency was expected for the microdialysate catheters and experimentally verified, which provides a straightforward correction of any dialysis recovery rate variation during patient monitoring.

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“…An early study (77) on the accuracy and reliability of a CGM system at altitude is promising, but further studies are warranted. Some CGMs are susceptible to interference caused by local tissue hypoxia, temperature, and chemicals such as, among others, acetaminophen (78,79).…”

Section: Blood Glucose Monitoringmentioning

confidence: 99%

Physical Activity at Altitude: Challenges for People With Diabetes

Mol

Vries²,

Koning

et al. 2014

Diabetes Care

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A growing number of subjects with diabetes take part in physical activities at altitude such as skiing, climbing, and trekking. Exercise under conditions of hypobaric hypoxia poses some unique challenges on subjects with diabetes, and the presence of diabetes can complicate safe and successful participation in mountain activities. Among others, altitude can alter glucoregulation. Furthermore, cold temperatures and altitude can complicate accurate reading of glucose monitoring equipment and storage of insulin. These factors potentially lead to dangerous hyperglycemia or hypoglycemia. Over the last years, more information has become available on this subject. PURPOSETo provide an up-to-date overview of the pathophysiological changes during physical activity at altitude and the potential problems related to diabetes, including the use of (continuous) blood glucose monitors and insulin pumps. To propose practical recommendations for preparations and travel to altitude for subjects with diabetes. DATA SOURCES AND SYNTHESISWe researched PubMed, medical textbooks, and related Internet sites, and extracted human studies and data based on relevance for diabetes, exercise, and altitude. LIMITATIONSGiven the paucity of controlled trials regarding diabetes and altitude, we composed a narrative review and filled in areas lacking diabetes-specific studies with data obtained from nondiabetic subjects. CONCLUSIONSSubjects with diabetes can take part in activities at high, and even extreme, altitude. However, careful assessment of diabetes-related complications, optimal preparation, and adequate knowledge of glycemic regulation at altitude and altitude-related complications is needed.An increasing number of subjects with diabetes reside at high altitude for short periods of time, partly for work, but mainly for recreational purposes such as skiing, trekking, and climbing. Exercise under conditions of hypobaric hypoxia poses some unique challenges for subjects with diabetes and could potentially lead to dangerous situations such as unexpected hypoglycemia and hyperglycemia, inaccurate

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GlucoMen Day Continuous Glucose Monitoring System: A Screening for Enzymatic and Electrochemical Interferents

Cited by 35 publications

References 16 publications

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry

Physical Activity at Altitude: Challenges for People With Diabetes

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