Gluconeogenesis from glycerol in fasting rats

Nikkilä, Esko A.; Ojala, Kaarina

doi:10.1016/0024-3205(64)90066-9

Cited by 42 publications

(18 citation statements)

References 18 publications

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“…The precise amount of glucose formed from glycerol is not well established and reported values in the fasted rat range from 75-90% (24) to 18% (5). This discrepancy is partially due to difficulties in determining the endogenous glycerol space (11), because after administration of glycerol, the molecule is metabolized before being ho mogenized in the plasma.…”

Section: Introductionmentioning

confidence: 89%

<i>In vivo </i>Glycerol Metabolism in the Pregnant Rat

Chaves

Herrera

1980

Neonatology

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Pregnant rats at 12 and 21 days of gestation and their virgin controls were injected intravenously with U-¹⁴C-glycerol and decapitated 1, 3, or 10 min later. The conversion of labelled glycerol to ¹⁴C-glucose was augmented in the 21-day pregnant rats. The disappearance of the newly formed ¹⁴C-glucose from blood was faster in both 12- and 21-day pregnant rats than in their controls, being partially retained as liver ¹⁴C-glycogen. The greatest amount of radioactivity in all tissues appeared in the carcass hydrosoluble fraction. This amount was smaller in the pregnant rats. The reduced utilization of glycerol by extrahepatic tissues allowed the 21-day pregnant rats to dispose a greater amount of this substrate for gluconeogenesis.

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Section: Introductionmentioning

confidence: 89%

<i>In vivo </i>Glycerol Metabolism in the Pregnant Rat

Chaves

Herrera

1980

Neonatology

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“…The role of glycerol in energy metabolism has not been well clarified, especially as compared to the Received for publication 20 December 1971 and in revised form 30 January 1972. participation of fatty acid. Further, although glycerol has been shown to be an active precursor for glucose in vivo and in vitro (4)(5)(6)(7)(8), its participation in human gluconeogenesis has not been quantitated. This role may become important during periods of caloric deprivation.…”

Section: Introductionmentioning

confidence: 99%

Glycerol turnover and oxidation in man

Bortz¹,

Paul²,

Haff³

et al. 1972

J. Clin. Invest.

212

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A BST RA CT The oxidation and turnover of plasma glycerol has been studied in lean and obese, fed and starving man by means of a long-term infusion of glycerol-"4C, and the participation of glycerol in gluconeogenesis has been determined.Under none of the experimental conditions did glycerol contribute more than 10% of the total respiratory C02. Glycerol turnover in fed lean subjects was 106 mmoles/min. Glycerol levels and turnover were higher in the obese subjects and with all subjects after starvation. There was a direct correlation between plasma levels and turnover values for which a regression equation was derived: y = 1556 x + 33.1, when y= turnover in micromoles per minute and x = glycerol level in micromoles per milliliter.Whereas a. direct relation was established between glycerol and FFA levels, the FFA/glycerol turnover ratio was 4.7: 1 in the lean group indicating incomplete hydrolysis of adipose tissue triglycerides.

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“…Previous in vivo studies on glycerol metabo lism have shown that plasma glucose is rapidly labelled when a tracer dose of glycerol-14C is injected into the circulation of the rat (6,17). The participation of glycerol to gluconeogenesis might become important in the fasting state comparatively to the normal fed state (17).…”

Section: Introductionmentioning

confidence: 99%

“…To obtain dynamic data about the plasma glycerol it is necessary to use the isotope dilution technique. The turnover rate of glycerol has been studied in sheep (1), man (2), dog (9), rabbit (10) and rat (17). With the single injec tion technique it is necessary to determine the glycerol pool size for the calculation of the turnover.…”

Section: Introductionmentioning

confidence: 99%

Glycerol Metabolism in the Pregnant and Virgin Rats

Ricquier¹

1977

Neonatology

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The parameters of in vivo glycerol kinetic curves were determined after a single injection of glycerol-1-¹⁴C in pregnant and in virgin rats. The half-life of glycerol was found to be 9 min in pregnant rats and 17 min in virgin rats. There was no significant difference between the absolute turnover rates. The glycerol plasma space cannot be appreciated. The distribution volume expressed in milliliter of plasma appeared to be very high indicating that glycerol was not distributed only in the plasma. Glycerol was found to be a precursor of glucose and this conversion seemed to proceed more rapidly in the pregnant rat than in the virgin rat.

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Gluconeogenesis from glycerol in fasting rats

Cited by 42 publications

References 18 publications

<i>In vivo </i>Glycerol Metabolism in the Pregnant Rat

<i>In vivo </i>Glycerol Metabolism in the Pregnant Rat

Glycerol turnover and oxidation in man

Glycerol Metabolism in the Pregnant and Virgin Rats

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