Gluconeogenesis in Neonatal Piglet Liver

Bieber, L.L.; Helmrath, Thomas A.; Dolanski, Eugene; Olgaard, M K; Choi, Yuna; Bélanger, Luc

doi:10.2527/jas1979.491250x

Cited by 13 publications

(3 citation statements)

References 6 publications

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“…Due to the lack of body fat (de Passill~ and Hartsock, 1979), a questionable ability to mobilize body lipid (Seerley et al, 1974), little hepatic capacity to oxidize fatty acids (Bieber et al, 1973) and the lack of gluconeogenic capacity sufficient to balance glucose demand (Bieber et al, 1979), the neonatal pig is dependent on tissue glycogen reserves as a source of metabolic fuel during periods of food deprivation (Boyd et al, 1978). Mersmann (1974) concluded that the high rate of neonatal mortality in swine was attributable, in part, to inadequate energy deposition during uterine development processes, complicated by poorly developed metabolic pathways at the time of birth.…”

Section: Introductionmentioning

confidence: 99%

Fetal Hepatic and Neural Substrate Utilization as Affected by Induced Nutritional Ketosis in Swine

Steele¹,

Rosebrough²,

McMurtry³

1984

Journal of Animal Science

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Systemic ketosis was induced in first-parity gilts by the isocaloric substitution of glucose with 1,3-butylene glycol to supply 20% of the total dietary energy beginning on d 23 (23 BG) or d 60 (60 BG) of gestation. Ketosis reduced (P less than .05) maternal plasma glucose, urea N and insulin concentrations. Fetal carcass dry matter and carcass glycogen contents were reduced (P less than .05) by maternal ketogenic calorie substitution, whereas fetal hepatic glycogen and lipid contents were not influenced by maternal treatment. Neural acetate oxidation was reduced (P less than .05) in the 23 BG and 60 BG fetuses, with a concurrent increase (P less than .05) in beta-hydroxybutyrate (BOHB) oxidation. Neural lipogenesis measured from acetate and BOHB substrates was nominal in the d 105 pig fetus. Fetal hepatic acetate and BOHB utilization for lipogenesis were increased (P less than .05) by maternal ketosis. Reproductive performance characteristics (litter size, number stillborn and birth weight) were not improved by maternal ketosis. The substantial improvement in lactation weight gain by litters from 23 BG and 60 BG dams (20%, P less than .05) may suggest a carryover effect of gestation dietary treatment on lactation performance.

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Section: Introductionmentioning

confidence: 99%

Fetal Hepatic and Neural Substrate Utilization as Affected by Induced Nutritional Ketosis in Swine

Steele¹,

Rosebrough²,

McMurtry³

1984

Journal of Animal Science

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“…The developing fetus requires large amounts of glucose, primarily for use as an energy source. Because gluconeogenesis does not occur to an appreciable degree in the fetus, glucose is an essential nutrient that must be derived either from the maternal circulation or from placental metabolism (67)(68)(69). An extensive body of work, performed in pregnant sheep, has demonstrated that glucose is taken up by the placenta, primarily from the maternal circulation, but also from the fetal circulation, suggesting the critical importance of adequate placental function during pregnancy (41).…”

Section: Glucose Transfermentioning

confidence: 99%

Fetal Nutrition: How We Become What We Are

McClellan,

Novak

2001

J. pediatr. gastroenterol. nutr.

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“…Vet. glasnik 68(3)(4) 175 -188 (2014) Kirovski Danijela i sar. : Biološki značaj razlika u sastavu kolostruma i mleka krava i krmača…”

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The biological significance of differences in cows and sows colostrum and milk composition

et al. 2014

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The objective of this work was to compare the composition of colostrum and milk of cows and sows (content of dry matter, protein, milk fat and lactose, concentration of IGF-I and insulin) in samples taken on the first, second, third and seventh day after parturition, and then based on the differences in composition to determine a biological significance of nutrition of newborn during the earliest stages of their life. The investigation inluded 14 cows of Holstein breed and 14 sows of Landrace breed. The content of dry matter and the concentration of proteins in both colostrum and milk samples were statistically significantly higher in regard to sows mammary glands secretion, taken on the first day after the parturition (p<0,01 and p<0,001, individually), but their decrease in mammary glands secretion was more pronounced in the cows than the sows, during the first seven days. The concentration IGF-I was statistically significantly higher in the cows colostrum and milk in regard to the sows during the whole investigation period, while the concentration of insulin was significantly higher in the sows in regard to the cows during the same period. The concentrations of milk fat and lactose in cows milk samples were significantly lower in regard to the sows in all period of the study. On the basis of the obtained results, it can be concluded that there are significant differences in the composition of milk and colostrum of both the investigated animal species. The differences are probably the result of evolutionary adaptation of mammal gland function to nutrition, energy and protection requirements of these young animals in their early postnatal life. [Projekat Ministarstva nauke Republike Srbije, br. III 46002]

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Gluconeogenesis in Neonatal Piglet Liver

Cited by 13 publications

References 6 publications

Fetal Hepatic and Neural Substrate Utilization as Affected by Induced Nutritional Ketosis in Swine

Fetal Hepatic and Neural Substrate Utilization as Affected by Induced Nutritional Ketosis in Swine

Fetal Nutrition: How We Become What We Are

The biological significance of differences in cows and sows colostrum and milk composition

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