Gluconic Acid Production from Golden Syrup by Aspergillus niger Strain using Semiautomatic Stirred-Tank Fermenter

Purane, Nilesh K

doi:10.4172/1948-5948.1000077

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…112 It is used in construction and in production of chemicals, pharmaceuticals, foods, beverages, textiles and leather. Substrates include glucose, sucrose and golden syrup, a by-product of the process refining sugar cane juice into sugar, or by treating sugar with acid.…”

Section: Organic Acidsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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Section: Organic Acidsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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“…Hlasewetz and Habermann discovered gluconic acid in 1870, this molecule is a natural constituent abundantly available in plants and fruits such as rice, meat, wine and honey; it is produced by different microorganisms, bacteria, and fungi …”

Section: Introductionmentioning

confidence: 99%

Acid–Base and Thermodynamic Properties ofd-Gluconic Acid and Its Interaction with Sn²⁺and Zn²⁺

et al. 2016

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In this paper, new potentiometric, calorimetric, and voltammetric measurements are reported to model the behavior of D-gluconic acid in aqueous NaCl (aq) and NaNO 3(aq) ionic media at different ionic strengths and temperatures (283.15 ≤ T/K ≤ 318.15) also in the presence of Sn 2+ and Zn 2+ . The protonation constants of D-gluconic acid (Gluc − in its deprotonated form) in NaCl (aq) and NaNO 3(aq) are very similar. The dependence on ionic strength of the protonation constant was modeled by means of the extended Debye−Huckel type equation, the Specific ion Interaction Theory (SIT) and a weak interaction model. At infinite dilution and T = 298.15 K, the thermodynamic parameters for the proton binding reaction, determined by direct calorimetric titrations and temperature gradients of protonation constants, are log K H0 = 3.709 ± 0.004, ΔG 0 = −21.18 ± 0.01 kJ mol −1 , ΔH 0 = −4.56 ± 0.04 kJ mol −1 , and TΔS 0 = 16.6 ± 0.1 kJ mol −1 , indicating that the reaction is exothermic and entropic in nature. Potentiometric and voltammetric measurements on the Sn 2+ and Zn 2+ /Gluc − systems allowed us to determine the MGluc + species for both systems at different ionic strengths, together with the Sn(Gluc) 2 and Sn(OH)Gluc species. The values of the formation constant of the SnGluc + species are higher than the corresponding ZnGluc + . During the experiments, the precipitation of insoluble species was evidenced at pH ≥ 4.0 for Sn 2+ /Gluc − and pH ≥ 7.0 for Zn 2+ /Gluc − . The stoichiometry of the precipitates was established by means of thermogravimetric analysis, and the solubility of the two salts, Sn(OH)Gluc (s) and Zn(Gluc) 2(s) , was determined in pure water, in NaCl and in NaNO 3 aqueous media. In pure water, the total solubility is S T = 0.262 ± 0.001 and 0.082 ± 0.006 mol kg −1 for the ZnGluc 2 and Sn(OH)Gluc, respectively. Calorimetric measurements were performed to determine the enthalpy changes of the gluconate protonation and Sn 2+ complex formation constants at different ionic strengths. The effect of two anions, as fluoride and citrate, on the stability of the Sn 2+ / Gluc − species was studied by means of potentiometric measurements at I = 0.15 and 1.02 mol kg −1 , and it was found that the formation of mixed complexes is thermodynamically favored.

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“…Gluconic acid (GA) is a multifunctional carboxylic acid with a low corrosive capacity which presents good complexation with metal ions. This allows GA and its salts (calcium, sodium or potassium gluconates) to be widely used in the food, pharmaceutical and textile industries [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Combi-CLEAs of Glucose Oxidase and Catalase for Conversion of Glucose to Gluconic Acid Eliminating the Hydrogen Peroxide to Maintain Enzyme Activity in a Bubble Column Reactor

et al. 2019

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In this study combined cross-linked aggregates of catalase from bovine liver and glucose-oxidase from Aspergillus niger were prepared, and the effects of the precipitant and crosslinking agents, as well as the use of bovine serum albumin (BSA) as a feeder protein, on enzyme immobilization yield and thermal stability of both enzymes, were evaluated. Combi- crosslinking of enzyme aggregates (CLEAs) prepared using dimethoxyethane as precipitant, 25 mM glutaraldehyde and BSA/enzymes mass ratio of 5.45 (w/w), exhibited the highest enzyme activities and stabilities at 40 °C, pH 6.0, and 250 rpm for 5 h. The stability of both immobilized enzymes was fairly similar, eliminating one of the problems of enzyme coimmobilization. Combi-CLEAs were used in gluconic acid (GA) production in a bubble column reactor operated at 40 °C, pH 6.0 and 10 vvm of aeration, using 26 g L−1 glucose as the substrate. Results showed conversion of around 96% and a reaction course very similar to the same process using free enzymes. The operational half-life was 34 h, determined from kinetic profiles and the first order inactivation model. Combi-CLEAs of glucose-oxidase and catalase were shown to be a robust biocatalyst for applications in the production of gluconic acid from glucose.

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Gluconic Acid Production from Golden Syrup by Aspergillus niger Strain using Semiautomatic Stirred-Tank Fermenter

Cited by 13 publications

References 23 publications

Production of valuable compounds by molds and yeasts

Production of valuable compounds by molds and yeasts

Acid–Base and Thermodynamic Properties ofd-Gluconic Acid and Its Interaction with Sn²⁺and Zn²⁺

Combi-CLEAs of Glucose Oxidase and Catalase for Conversion of Glucose to Gluconic Acid Eliminating the Hydrogen Peroxide to Maintain Enzyme Activity in a Bubble Column Reactor

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Gluconic Acid Production from Golden Syrup by Aspergillus niger Strain using Semiautomatic Stirred-Tank Fermenter

Cited by 13 publications

References 23 publications

Production of valuable compounds by molds and yeasts

Production of valuable compounds by molds and yeasts

Acid–Base and Thermodynamic Properties ofd-Gluconic Acid and Its Interaction with Sn2+and Zn2+

Combi-CLEAs of Glucose Oxidase and Catalase for Conversion of Glucose to Gluconic Acid Eliminating the Hydrogen Peroxide to Maintain Enzyme Activity in a Bubble Column Reactor

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Product

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About

Acid–Base and Thermodynamic Properties ofd-Gluconic Acid and Its Interaction with Sn²⁺and Zn²⁺