Gluconic Acid Production from Potato Waste by <i>Gluconobacter oxidans</i> Using Sequential Hydrolysis and Fermentation

Jiang, Yi; Liu, Kuimei; Zhang, Hongsen; Wang, Yingli; Yuan, Quanquan; Su, Ning; Bao, Jie; Xu, Fang

doi:10.1021/acssuschemeng.7b00992

Cited by 41 publications

(21 citation statements)

References 54 publications

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“…Microbial fermentation does not consume as many raw materials and operates at less severe operating conditions compared to chemical oxidation. However, fermentation also suffers from various disadvantages such as long fermentation time (more than 2 days), low selectivity (GRA yield < 20%), and difficulty in product separation (large amounts of microbial biomass and hundreds of byproducts with similar properties are coproduced) 31 .…”

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confidence: 99%

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

et al. 2020

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Glucose electrolysis offers a prospect of value-added glucaric acid synthesis and energysaving hydrogen production from the biomass-based platform molecules. Here we report that nanostructured NiFe oxide (NiFeO x ) and nitride (NiFeN x ) catalysts, synthesized from NiFe layered double hydroxide nanosheet arrays on three-dimensional Ni foams, demonstrate a high activity and selectivity towards anodic glucose oxidation. The electrolytic cell assembled with these two catalysts can deliver 100 mA cm −2 at 1.39 V. A faradaic efficiency of 87% and glucaric acid yield of 83% are obtained from the glucose electrolysis, which takes place via a guluronic acid pathway evidenced by in-situ infrared spectroscopy. A rigorous process model combined with a techno-economic analysis shows that the electrochemical reduction of glucose produces glucaric acid at a 54% lower cost than the current chemical approach. This work suggests that glucose electrolysis is an energy-saving and cost-effective approach for H 2 production and biomass valorization.

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confidence: 99%

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

et al. 2020

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“…These dehydrogenases can rapidly and efficiently oxidise alcohols/sugars/ketones to corresponding sugars/ketones/acids. Strains have been widely used in the production of 1,3-dihydroxyacetone [19], gluconic acid [20] and vitamin C [21]. Regarding 2-KGA accumulation, there are two synthesis pathways in Gluconobacter (Fig.…”

Section: Introductionmentioning

confidence: 99%

Efficient biosynthesis of 2-keto-D-gluconic acid by fed-batch culture of metabolically engineered Gluconobacter japonicus

Zeng

Cai

Liu

et al. 2019

Synthetic and Systems Biotechnology

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2-keto- d -gluconic acid (2-KGA) is a key precursor for synthesising vitamin C and isovitamin C. However, phage contamination is as constant problem in industrial production of 2-KGA using Pseudomonas fluorescens . Gluconobacter holds promise for producing 2-KGA due to impressive resistance to hypertonicity and acids, and high utilisation of glucose. In this study, the 2-KGA synthesis pathway was regulated to enhance production of 2-KGA and reduce accumulation of the by-products 5-keto- d -gluconic acid (5-KGA) and d -gluconic acid (D-GA) in the 2-KGA producer Gluconobacter japonicus CGMCC 1.49. Knocking out the ga5dh-1 gene from a competitive pathway and overexpressing the ga2dh-A gene from the 2-KGA synthesis pathway via homologous recombination increased the titre of 2-KGA by 63.81% in shake flasks. Additionally, accumulation of 5-KGA was decreased by 63.52% with the resulting G. japonicas -Δ ga5dh-1 - ga2dh-A strain. Using an intermittent fed-batch mode in a 3 L fermenter, 2-KGA reached 235.3 g L −1 with a 91.1% glucose conversion rate. Scaling up in a 15 L fermenter led to stable 2-KGA titre with productivity of 2.99 g L −1 h −1 , 11.99% higher than in the 3 L fermenter, and D-GA and 5-KGA by-products were completely converted to 2-KGA.

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“…In recent years, expeditiously dwindling fossil fuels and rapidly increasing demand for chemicals and energy have driven the shift toward the exploration of alternative resources. − Biomass is a complex biopolymer, which is primarily composed of carbohydrates (hemicelluloses plus cellulose) and lignin. , It has been widely utilized as a sustainable, abundant, inexpensive, and available bioresource for the highly efficient production of high value-added biofuels and biobased chemicals. − The hemicellulose component accounts for 15–30% of the total lignocellulosic biomass. As one kind of hemicellulose-derived biobased chemicals, furfural (FAL) is a renewable platform molecule, which is widely used in fuels, resins, oil refining, plastics, pharmaceuticals, and agrochemical industries .…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Chemoenzymatic Cascade Catalysis of Biomass into Furfurylamine by a Heterogeneous Shrimp Shell-Based Chemocatalyst and an ω-Transaminase Biocatalyst in Deep Eutectic Solvent–Water

Ni¹,

Gong³

et al. 2021

ACS Sustainable Chem. Eng.

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Recently, the cost-effective production of high value-added furan chemicals from inexpensive, abundant, and renewable bioresources has gained much attention via a chemoenzymatic approach in an environmentally friendly reaction system. Furfurylamine is an important furan-based chemical for the production of additives, fibers, perfumes, agrochemicals, and pharmaceuticals. This study attempted to develop one sustainable approach for the production of furfurylamine via chemoenzymatic cascade catalysis of biomass into furfurylamine using a chemocatalyst and a biocatalyst. Using alkali-treated shrimp shells as the biobased support, a tin-based heterogeneous chemocatalyst (Sn-DAT-SS) was first prepared to transform corncob into furfural in 52.4% yield in deep eutectic solvent choline chloride:ethylene glycol (ChCl:EG)–water (10:90, v/v) at 170 °C within 0.5 h. Sn-DAT-SS was easy to recover and has good reusability. Detailed investigation using Fourier transform infrared (FT-IR) spectroscopy, Brunauer–Emmett–Teller (BET) analysis, temperature-programmed desorption of NH3 (NH3-TPD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) indicated that the Lewis and Brönsted acid sites existed on the surface of Sn-DAT-SS. The possible catalytic mechanism of the Sn-DAT-SS-catalyzed transformation of corncob into furfural in ChCl:EG–water was presented. To biologically synthesize furfurylamine, newly constructed recombinant Escherichia coli CCZU-XLS160 whole-cells harboring ω-transaminase and l-alanine dehydrogenase were used to catalyze biomass-derived furfural using available inexpensive NH4Cl (2.0 mol NH4Cl/mol furfural) as the amine donor in ChCl:EG–water (10:90, v/v) at 35 °C and pH 7.5. Within 71.5 h, 92.3 mM furfural derived from corncob was wholly transformed into furfurylamine with a productivity of 0.39 g furfurylamine/g xylan in corncob in ChCl:EG–water (10:90, v/v). This work demonstrated an environmentally friendly chemoenzymatic strategy for utilizing lignocellulosic biomass into furfurylamine via tandem chemocatalysis and biocatalysis in green reaction media. It was feasible to obtain furfurylamine from a renewable source consisting of corncob and shrimp shells.

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Gluconic Acid Production from Potato Waste by Gluconobacter oxidans Using Sequential Hydrolysis and Fermentation

Cited by 41 publications

References 54 publications

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Efficient biosynthesis of 2-keto-D-gluconic acid by fed-batch culture of metabolically engineered Gluconobacter japonicus

Highly Efficient Chemoenzymatic Cascade Catalysis of Biomass into Furfurylamine by a Heterogeneous Shrimp Shell-Based Chemocatalyst and an ω-Transaminase Biocatalyst in Deep Eutectic Solvent–Water

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