Glucose-6-Phosphate Dehydrogenase

Luzzatto, Lucio; Battistuzzi, G.

doi:10.1007/978-1-4615-9400-0_4

Cited by 99 publications

(122 citation statements)

References 375 publications

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“…G lucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme that catalyzes the first step in the pentose phosphate pathway that produces riboses, which are incorporated into nucleic acids, and NADPH, the major cytoplasmic reducing compound (Luzzatto and Battistuzzi 1985). NADPH plays important roles in cells.…”

mentioning

confidence: 99%

Posttranslational Regulation of Glucose-6-phosphate Dehydrogenase Activity in Tongue Epithelium

Biagiotti

Bosch

Ninfali

et al. 2000

J Histochem Cytochem.

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(PN) S U M M A R Y Expression of glucose-6-phosphate dehydrogenase (G6PD) activity is high in tongue epithelium, but its exact function is still unknown. It may be related either to the high proliferation rate of this tissue or to protection against oxidative stress. To elucidate its exact role, we localized quantitatively G6PD activity, protein and mRNA using image analysis in tongue epithelium of rat and rabbit, two species with different diets. Distribution patterns of G6PD activity were largely similar in rat and rabbit but the activities were twofold lower in rabbit. Activity was two to three times higher in upper cell layers of epithelium than in basal cell layers, whereas basal layers, where proliferation takes place, contained twice as much G6PD protein and 40% more mRNA than upper layers. Our findings show that G6PD is synthetized mainly in basal cell layers of tongue epithelium and that it is posttranslationally activated when cells move to upper layers. Therefore, we conclude that the major function of G6PD activity in tongue epithelium is the formation of NADPH for protection against oxidative stress and that diet affects enzyme expression in this tissue.

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mentioning

confidence: 99%

Posttranslational Regulation of Glucose-6-phosphate Dehydrogenase Activity in Tongue Epithelium

Biagiotti

Bosch

Ninfali

et al. 2000

J Histochem Cytochem.

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“…This linkage is very stable and linkage with other group locuses is similar in all mammals (Luzzatto & Battistuzzi, 1985, Group, 1989, Luzzatto, 1989, Beutler, 1990. In mice, X-linkage of G6PD was shown by Epstein (Epstein, 1969).…”

Section: Introductionmentioning

confidence: 79%

“…G6PD is a typical cytoplasmic, housekeeping enzyme and has been found in all cells from liver to kidney and organisms, from prokaryotes to yeasts, to protozoa, to plants and animals (Luzzatto & Battistuzzi, 1985, Antonenkov, 1989, Glader, 1999, Notaro, et al, 2000. Inactive form of G6PD is a monomer with 515 amino acids and has a molecular weight of over 59 kDa (Rattazzi, 1968).…”

Section: Structure Of G6pd and Enzymatic Propertiesmentioning

confidence: 99%

“…Up to 450 G6PD variants have been identified depending on the enzyme kinetics, physicochemical characteristics, and other parameters (Luzzatto & Battistuzzi, 1985, Chen, et al, 1991. Nearly 300 variants of these have been confirmed by the World Health Organization (1967).…”

Section: Introductionmentioning

confidence: 98%

“…If one of the alleles contains deficiency, as a result of random deactivation of X-chromosomes, about half of the cells will be normal and the other half will be deficient, although there is a wide range of variation around that average (Nance, 1964, Rinaldi, et al, 1976. For this reason, total G6PD activity in heterozygous females can show variability between near-normal to near-deficient (Luzzatto & Battistuzzi, 1985, Segel, 2000. Deactivation of X-chromosome actualizes at random.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glucose-6-Phosphate Dehydrogenase Deficiency and Malaria: A Method to Detect Primaquine-Induced Hemolysis in vitro

Allahverdiyev¹,

Bağırova²,

Elcicek³

et al. 2012

Dehydrogenases

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Biodemoraphy and genetics of the Berba of Benin

Biondi

Rickards

Martínez-Labarga

et al. 1996

Am. J. Phys. Anthropol.

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Genetic structure of the Berba of Benin was studied on the basis of biodemographic data and ABO, RH, MNS, KEL, JK, FY, ACP1, ADA, AK1, CA2, ESD, GLO1, G6PD, PGD, PGM1 (subtypes and thermostability), PGM2, PGP, SODA, HB alpha, HB beta, HB delta, BF, C3, and HP gene frequencies. Comparisons were carried out with other populations of Benin and of sub-Saharan Africa. Correspondence analysis revealed genetic differentiation among the three main groups of populations who inhabit sub-Saharan Africa: Bushmen-Hottentots, Pygmies, and Negroes. The genetic differentiation of the Negroes in relation to their linguistic affiliation and geographic localization was evident. The first group included the populations belonging to the Bantoid subfamily of the Nigritic linguistic stock living in southern Africa; in the second subcluster the populations of central-eastern Africa were localized, and the third subcluster included the populations living in the West.

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Glucose-6-Phosphate Dehydrogenase

Cited by 99 publications

References 375 publications

Posttranslational Regulation of Glucose-6-phosphate Dehydrogenase Activity in Tongue Epithelium

Posttranslational Regulation of Glucose-6-phosphate Dehydrogenase Activity in Tongue Epithelium

Glucose-6-Phosphate Dehydrogenase Deficiency and Malaria: A Method to Detect Primaquine-Induced Hemolysis in vitro

Biodemoraphy and genetics of the Berba of Benin

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