Glucose-6-Phosphate Dehydrogenase Deficiency Trait in Nigeria

Gilles, H. M.; Watson-Williams, J.; Taylor, Bernard

doi:10.1038/185257b0

Cited by 18 publications

(5 citation statements)

References 2 publications

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“…This was close to the frequency of 6% reported from the same centre in the 1960’s [35]. The frequency of G6PD deficiency was higher among boys compared to girls.…”

Section: Discussionsupporting

confidence: 87%

Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria

Ajetunmobi

Orimadegun

et al. 2012

Malar J

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BackgroundHaemoglobinuria is one of the manifestations of severe malaria and results from severe intravascular haemolysis. Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been implicated in its aetiology. Haemoglobinuria may be associated with severe anaemia and, less frequently, acute renal failure.MethodsA prospective case-control study was carried out to determine the incidence of haemoglobinuria as confirmed by dipstick urinalysis, microscopy and spectrophotometric measurement, among children with severe malaria. A total of 251 children presenting at the Children’s Emergency Ward with severe malaria were recruited over a period of 21 months. The G6PD status and the outcomes of severe malaria in children with and without haemoglobinuria was studied with respect to renal failure, the recurrence of haemoglobinuria and blood pressure changes over a three-month follow-up period.ResultsIt was found that the incidence of haemoglobinuria among children with severe malaria is 19.1%. Children <5 years constituted 76.8% of all the study patients. Patients with haemoglobinuria had median age of 52.5 months, which was significantly higher than 35 months in patients without haemoglobinuria (p=0.001). Although, haemaglobinuria was commoner among boys (54.2%) than girls (45.8%), the difference was not statistically significant. There were no significant differences between children with and without haemoglobinuria regarding their nutritional status or parasite densities. Among the clinical features of the study patients, only jaundice was significantly associated with haemoglobinuria (p=0.0001). Renal failure occurred in three out of 48 children with haemoglobinuria and in none of the 203 without. There was not recurrence of haemoglobinuria in the follow-up period. At discharge, blood pressure was elevated in six children (one previously haemoglobinuric), but all returned to normal within the follow-up period.ConclusionsHaemoglobinuria was a prominent feature of severe malaria and it was significantly associated with jaundice at presentation. Haemoglobinuria was commoner in older children than younger children but not related to sex. G6PD deficiency was not an independent predictor of the occurrence or outcome of haemoglobinuria. Blood pressure was not affected by haemoglobinuria on admission nor during follow-up.

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“…This was close to the frequency of 6% reported from the same centre in the 1960’s [35]. The frequency of G6PD deficiency was higher among boys compared to girls.…”

Section: Discussionsupporting

confidence: 87%

Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria

Ajetunmobi

Orimadegun

et al. 2012

Malar J

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“…"5 The possibility that glucose 6-phosphate dehydrogenase may play a role in this form of hemolysis has been suggested. 52 Sulfonamides. After the introduction of sulfonamides and their widespread use immediately prior to W orId War II, the occurrence of hemolysis complicating this therapy was soon recognized.…”

Section: Drugs Causing Hemolytic Anemia Through Unknown Mechanismsmentioning

confidence: 99%

Hemolytic effects of drugs and chemical agents

Prankerd

1963

Clin Pharma and Therapeutics

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“…Congenital galactosemia is due to absence of galactowaldenase (Kalckar et al, 1956). Various forms of glycogen deposition diseases are due to lack of glucose-6-phosphatase, amylo-l-6-glucosidase or muscle phosphorylase (Hers and Malbrain, 1959;Hauk et al, 1959;Mommaerts et al, 1959; Yi Yung Hsia and Kot, 1959;Larner and Villar Palasi, 1959;Gilles et al, 1960). Pentosuria may be due to hereditary deficiency in xylulose dehydrogenase (Bozian and Touster, 1959).…”

Section: Chapter Imentioning

confidence: 99%

The biosynthesis of proteins

Chantrenne¹

1961

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Set in Imprint 11 on 12 point and printed in Great Britain at THE ALDEN PRESS. OXFORD au Professeur Jean BRACKET, mon maitre et mon ami Contents PAGE Preface 1. Induced synthesis of enzymes in micro-organisms 2. Repression of enzyme synthesis in micro-organisms 3. Mechanisms of repression and induction 4. Induced transformation of an enzyme 5. Permeases and enzyme synthesis 6. Enzymic adaptation in animal tissues B. Non-mendelian hereditary factors in enzyme synthesis C. Changes in protein synthesis during differentiation D. The formation of antibodies Subject Index Author Index 207Preface Knowledge on the biosynthesis of proteins is increasing so rapidly, and relevant data are obtained from such a variety of approaches that it is more and more difficult to keep abreast with the progress of research. Chemistry, crystallography, genetics, cytology, cellular physiology, embryology, immunology, microbiology, enzymology all contribute to the analysis of the process. It is obviously impossible to master all these sciences, and each worker must go his own way, trying his best with what he can do. But he must from time to time stop and look around to appreciate the advances made along the other lines of research, lest he might lose contact altogether with the other approaches. The author felt this necessity for himself and for the students in his laboratory, and he tried to outline a picture of the whole field of protein biosynthesis as he sees it presently. The outcome of his attempt was this little book, in which well established facts were merely summarized, and greater emphasis was laid upon recent developments and new perspectives. It is realized that the discussions and interpretations of recent data that this book contains will soon become obsolete : this is unavoidable in a field of research which is developing so rapidly. The picture presented here should be regarded as a snapshot taken at the end of 1960; blurred spots on the picture are due in part to the lens, and in part to the fog that still covers large regions of the field.

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Glucose-6-Phosphate Dehydrogenase Deficiency Trait in Nigeria

Cited by 18 publications

References 2 publications

Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria

Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria

Hemolytic effects of drugs and chemical agents

The biosynthesis of proteins

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