Glucose -6- phosphate dehydrogenase (g6pd) activity and deficiency in a population of Nigerian males resident in jos

Egesie, OJ; Joseph, DE; Isiguzoro, Ikechukwu; Egesie, UG

doi:10.4314/njps.v23i1-2.54908

Cited by 13 publications

(14 citation statements)

References 10 publications

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“…The higher prevalence of males with neonatal jaundice than females corroborated with the study of Hamid et al (2003) who had higher males with neonatal jaundice due to the fact that the enzyme level of the activity of G6PD was significantly lower in males than in females (George and Akani, 2011). But the result of the study disagreed with the studies of Sciuto et al (2009) and Egesie et al (2008) where they reported lower prevalence of neonatal jaundice in males. Males have lower levels of the enzymes activity of G6PD than the females in view of the fact that the defect is X-linked recessive resulting in the male's tendency to develop neonatal jaundice (George and Akani, 2011).…”

Section: Discussioncontrasting

confidence: 56%

Prevalence of neonatal jaundice in Eku Baptist Community Hospital in Delta State Nigeria

Kolawole¹,

Obueh²,

Okandeji-Barry³

2016

J. Public Health Epidemiol.

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A total of 2,509 neonatal case folders were reviewed to determine the prevalence, pattern of occurrence, and associated risk factors of neonatal jaundice among the newborn babies aged between 1 and 28 days. Neonatal jaundice accounted for a total prevalence of 52. 6 in 1000 of the total number of cases reviewed. There was significant prevalence (p≤0.05) of neonatal jaundice in males (67.4) than in females (43.6). The risk factors of neonatal jaundice identified were sepsis (66.7%), prematurity (15.2%), lack of breast feeding (9.0%), ABO incompatibility (5.2%), and anaemia (3.8%). Two deaths were recorded from neonatal jaundice due to sepsis. Although the prevalence of neonatal jaundice was low, there is need to educate women on regular antenatal checks and delivery in appropriate health care facility in order to curb the incidence of neonatal jaundice.

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Section: Discussioncontrasting

confidence: 56%

Prevalence of neonatal jaundice in Eku Baptist Community Hospital in Delta State Nigeria

Kolawole¹,

Obueh²,

Okandeji-Barry³

2016

J. Public Health Epidemiol.

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“…In this study, prevalence of G6PD deficiency was 12.3% among male subjects while that of females was found to be 10.5%. This finding is similar to 26% among males and 20% among females as earlier reported (Luzzatto and Notaro, 2001;Ademowo and Falusi, 2002;Egesie et al, 2008). The higher occurrence observed among the male subjects may be due to the fact that G6PD gene is X -linked and therefore G6PD deficiency is an X-linked disorder.…”

Section: Discussionsupporting

confidence: 89%

Frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency among febrile patients in malaria-endemic communities in southwestern Nigeria

Nassar¹,

Olayiwola²,

Ogunmola³

2019

Ife Journal of Science

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Glucose-6-phosphate dehydrogenase (G6PD) enzyme plays an active role in survival of erythrocytes. The deficiency of G6PD in the red blood cells is a clinical problem attributed to neonatal jaundice and chronic hemolytic anemia. Three hundred and thirty three blood samples were collected from consenting participants and screened for G6PD using methaemoglobin reductase method and malaria parasite microscopically by using Giemsa staining technique. The data obtained were analyzed with SPSS (version 16) software as statistical tool with p value ≤ 0.05 as level of significance. The prevalence of G6PD deficiency in male and female participants was 27.2% and 19.2% respectively. There was no significant association between G6PD deficiency and sex (0.086). Fifty 50 (15%) of samples were positive for malaria (P. falciparum associated) with prevalence rate of 10.2% among female as against 4.6% found among male counterparts. There was significant association between malaria and gender (p-value = 0.04). Also, the rate of G6PD was higher in male (27.2%) than in female (19.5%) participants but not statistically significant (0.086). Low level of both G6PD deficiency and malaria (2.4%) was found. Due to possibility of G6PD deficiency, there is need for the diagnosis of G6PD in the management of malaria.

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“…Our finding is consistent with previous reports in Nigeria and other parts of the world. In previous reports in Nigeria, the prevalence of G6PD deficiency ranged from 4% to 26% 2–4. However, a study by Akanni et al5 in Oshogbo, Nigeria among 200 blood donors and 86 jaundiced neonates indicated G6PD deficiencies of 19.5% and 47.7%, respectively.…”

Section: Discussionmentioning

confidence: 92%

“…G6PD is an enzyme present in the cytoplasm of all cells, acting specifically in the maintenance of the integrity of the erythrocytes, preventing the oxidation of hemoglobin and other cellular proteins. In Nigeria, the prevalence of G6PD deficiency ranges from 4% to 26% 2–4. A study by Akanni et al in Oshogbo, Nigeria among 200 blood donors and 86 jaundiced neonates indicated G6PD deficiencies of 19.5% and 47.7%, respectively 5.…”

Section: Introductionmentioning

confidence: 99%

Glucose-6-phosphate dehydrogenase deficiency among children attending the Emergency Paediatric Unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

Isaac¹,

Mainasara²,

Erhabor³

et al. 2013

IJGM

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human enzyme deficiencies in the world. It is particularly common in populations living in malaria-endemic areas, affecting more than 400 million people worldwide. This present study was conducted with the aim of determining the prevalence of G6PD deficiency among children visiting the Emergency Paediatric Unit of Usmanu Danfodiyo University Teaching Hospital for pediatric-related care. The study included 118 children, made up of 77 (65.3%) males and 41 (34.7%) females aged ≤5 years with mean age of 3.26 ± 1.90 years. Randox G6PD quantitative in vitro test screening was used for the diagnosis of G6PD deficiency. Of the 118 children tested, 17 (14.4%) were G6PD-deficient. Prevalence of G6PD deficiency was concentrated predominantly among male children (22.1%). Male sex was significantly correlated with G6PD deficiency among the children studied (r = 7.85, P = 0.01). The highest prevalence occurred among children in the 2- to 5-year age-group. Of the 17 G6PD-deficient children, twelve (70.2%) were moderately deficient, while five (29.4%) were severely deficient. Blood film from G6PD-deficient children indicated the following morphological changes; Heinz bodies, schistocytes, target cells, nucleated red cells, spherocytes, and polychromasia. This present study has shown a high prevalence of G6PD deficiency among children residing in Sokoto in the northwestern geopolitical zone of Nigeria. The study indicated a male sex bias in the prevalence of G6PD deficiency among the children studied. There is a need for the routine screening of children for G6PD deficiency in our environment, to allow for evidence-based management of these children and to ensure the avoidance of food, drugs, and infective agents that can potentially predispose these children to oxidative stress as well as diseases that deplete micronutrients that protect against oxidative stress. There is need to build capacity in our setting among pediatricians to ensure the effective management of children with G6PD deficiency.

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Glucose -6- phosphate dehydrogenase (g6pd) activity and deficiency in a population of Nigerian males resident in jos

Cited by 13 publications

References 10 publications

Prevalence of neonatal jaundice in Eku Baptist Community Hospital in Delta State Nigeria

Prevalence of neonatal jaundice in Eku Baptist Community Hospital in Delta State Nigeria

Frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency among febrile patients in malaria-endemic communities in southwestern Nigeria

Glucose-6-phosphate dehydrogenase deficiency among children attending the Emergency Paediatric Unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

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