Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

Joseph, Biju; Shimojo, Guilherme Lemos; Li, Zhifeng; Thompson-Bonilla, María del Rocío; Shah, Roshan P.; Kanashiro, Alexandre; Salgado, Hélio César; Ulloa, Luis

doi:10.1038/s41598-018-36298-z

Cited by 27 publications

(15 citation statements)

References 77 publications

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“…Also, IL-10 that is produced by macrophages and T-cells is a potent inhibitor of macrophagederived inflammatory cytokines synthesis [54]. As pathogen activates the innate immune response through activation of the NF-B signaling pathways which is essential to the generations of inflammatory cytokines as TNF-αand interleukins which played a crucial role in fighting infection [55].In the current study, E.coli infected group showed a significant increase in serum level of TNF-α. and IL-10.…”

Section: Discussionmentioning

confidence: 56%

Effect of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

Elbaz

Hamed

Abdelhamid

et al. 2020

Mansoura Veterinary Medical Journal

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To evaluate the effect of cefepime on hematological changes, immunological disorders and hepatic oxidative damage in rats experimentally infected with E.coli ATCC 25922. Design: Randomized controlled experimental study. Animals: Thirty-two adult male albino rats weighting150-200 g. Procedures: Rats used for this study were randomly assigned into 4 equal groups: the control one, E.coli infected group (1×10 8 CFU/I/P/once), the cefepime treated group (45 mg/kg bw/I/M/day) for 5 days and the E.coli infected group that treated with cefepime 24h after bacterial inoculation as previously described. Hematological and immunological parameters, liver function biomarkers and hepatic oxidative stress and antioxidant markers were determined. Results: Our result revealed that E.coli infection induced a significant elevation in the erythrocytes count, hemoglobin concentration, PCV% and total leukocytic count (TLC) (P < 0.05). In the same respect, liver function biomarkers, serum glucose, total cholesterol, and triglyceride levels as well hepatic malondialdehyde (MDA), nitric oxide (NO), TNF-α, IL-10, and lysozyme activity were significantly increased compared to the control rats (P < 0.05). In contrast, hepatic reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were decreased significantly (P < 0.05). Cefepime treatment in E.coli + CFPM group reduced the elevated eythrogram, TLC and liver function biomarkers.Cefepime also ameliorated the oxidative damage and inflammatory response induced by E.coli infection. Conclusion and clinical relevance:Cefepime is safe when administered in a fixed-dose and possess antioxidant that contributes to improve efficacy against adverse effect induced by E.coli ATCC 25922 infection.

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Section: Discussionmentioning

confidence: 56%

Effect of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

Elbaz

Hamed

Abdelhamid

et al. 2020

Mansoura Veterinary Medical Journal

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“…Likewise, a recent study indicated that efferent vagal stimulation attenuates hyperglycemia in endotoxemia by inducing insulin in fasted mice [35] . However, while combined afferent and efferent cervical VNS impaired glucose tolerance and inhibited glucose-induced insulin secretion in conscious rats [12] .…”

Section: Discussionmentioning

confidence: 98%

Chronic vagus nerve stimulation for drug-resistant epilepsy influences fasting blood glucose concentration

Liu

Zhan

Meng

et al. 2020

Preprint

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Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose in patients with drug-resistant epilepsy.Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital in a randomized, controlled trial were retrospectively studied. Effects on fasting blood glucose, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up.Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in fasting blood glucose concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, p=0.001) and 12 (4.86±0.40 mmol/L, p=0.002) months of VNS, fasting blood glucose levels significantly increased compared to baseline values (4.52±0.54 mmol/L). Changes in fasting blood glucose concentrations at both 8 (R 2 =0.502, p<0.001) and 12 (R 2 =0.572, p<0.001) months were negatively correlated with baseline fasting blood glucose levels.Conclusions Our study suggests that chronic cervical VNS elevates fasting blood glucose levels with commonly used stimulation parameters in patients with epilepsy.Trial registration: VNSRE, NCT02378792. Registered 4 March 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02378792

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“…EA activates mechanisms that have physiologic limitations, and they are ineffective in patients with multiple comorbidities ( 57 , 58 ). One typical example is that EA on ST36 improves organ function and survival in experimental sepsis by inducing dopamine production in the adrenal glands ( 49 , 59 ). However, many septic patients have adrenal insufficiency, and thus they render insufficient dopamine production for EA to induce significant effects ( 49 , 60 , 61 ).…”

Section: Discussionmentioning

confidence: 99%

PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy

Huang

Guo

et al. 2021

Front. Immunol.

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Platinum-based chemotherapy is an effective treatment used in multiple tumor treatments, but produces severe side effects including neurotoxicity, anemia, and immunosuppression, which limits its anti-tumor efficacy and increases the risk of infections. Electroacupuncture (EA) is often used to ameliorate these side effects, but its mechanism is unknown. Here, we report that EA on ST36 and SP6 prevents cisplatin-induced neurotoxicity and immunosuppression. EA induces neuroprotection, prevents pain-related neurotoxicity, preserves bone marrow (BM) hematopoiesis, and peripheral levels of leukocytes. EA activates sympathetic BM terminals to release pituitary adenylate cyclase activating polypeptide (PACAP). PACAP-receptor PAC1-antagonists abrogate the effects of EA, whereas PAC1-agonists mimic EA, prevent neurotoxicity, immunosuppression, and preserve BM hematopoiesis during cisplatin chemotherapy. Our results indicate that PAC1-agonists may provide therapeutic advantages during chemotherapy to treat patients with advanced neurotoxicity or neuropathies limiting EA efficacy.

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Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

Cited by 27 publications

References 77 publications

Effect of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

Effect of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

Chronic vagus nerve stimulation for drug-resistant epilepsy influences fasting blood glucose concentration

PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy

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