Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery

Yin, Ruixue; Zi, Tong; Yang, Dongzhi; Nie, Jun

doi:10.1016/j.ijbiomac.2011.09.014

Cited by 67 publications

(31 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Yin et al [97] prepared glucose and pH responsive microhydrogels based on ConA for insulin delivery. Glucosyloxyethyl methacrylate (GEMA), acrylic glycomomnomer with a monosccharide residue and further photopolymerization of Con A-E/GEMA and N-(2-(dimethylamino) ethyl)-methacrylamide (DMAEMA), a cationic monomer containing tertiary amine functional group, led to the formation of microhydrogels that quickly responded to changes in glucose concentration and pH variations.…”

Section: Miscellaneous Hydrogelsmentioning

confidence: 99%

Polymeric hydrogels for oral insulin delivery

Chaturvedi¹,

Ganguly²,

Nadagouda³

et al. 2013

Journal of Controlled Release

229

154

View full text Add to dashboard Cite

Section: Miscellaneous Hydrogelsmentioning

confidence: 99%

Polymeric hydrogels for oral insulin delivery

Chaturvedi¹,

Ganguly²,

Nadagouda³

et al. 2013

Journal of Controlled Release

229

154

View full text Add to dashboard Cite

“…Insulin release in the environment with a pH of 6 was reported at 150% and 320% in comparison to the environment with a pH of 6.5 and 7.4, respectively. Also, after 1 h, the amount of insulin released in the environment with an upward glucose concentration (0, 4, 10, 14 mg mL −1 ) was almost twice the amount of insulin released in the glucose‐free environment . Zion et al.…”

Section: Further Improvements Of Insulin Delivery Systemsmentioning

confidence: 97%

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Taraghdari

Imani

Mohabatpour

2019

Macromolecular Bioscience

View full text Add to dashboard Cite

Diabetes mellitus (DM) is the most prevalent non‐contagious disease, which has affected a large number of people all over the world. Among all treatments known to have a positive influence in the control of DM, insulin therapy is the most common and effective one. Nowadays, various methods of insulin delivery are under investigation, which are able to reach a plausible bioavailability with ignorable side effects instead of insulin injection. This article presents a comprehensive review of the insulin therapy approach with a focus on modified methods in insulin delivery strategies and current advances in engineered insulin delivery systems.

show abstract

“…Nie group developed a series of Con A based microgels for GRIR [40,72,73]. Typical insulin-loaded microgels were prepared by copolymerization of glucosyloxyethyl methacrylate (GEMA), methacrylated concanavalin A (Con A-E), and a pH sensitive monomer N-(2-(dimethylamino) ethyl)-methacrylamide (DMAEMA) in insulin solution [72].…”

Section: Formulations Of Grir Systemmentioning

confidence: 99%

“…Typical insulin-loaded microgels were prepared by copolymerization of glucosyloxyethyl methacrylate (GEMA), methacrylated concanavalin A (Con A-E), and a pH sensitive monomer N-(2-(dimethylamino) ethyl)-methacrylamide (DMAEMA) in insulin solution [72]. The incorporation of Con A and DMAEMA enabled a glucose and pH dual-responsive system, which can sense the glucose concentration change and pH value change induced by the accumulation of acidic metabolites in diabetes.…”

Section: Formulations Of Grir Systemmentioning

confidence: 99%

Glucose-responsive insulin release: Analysis of mechanisms, formulations, and evaluation criteria

Yang

Cao

2017

Journal of Controlled Release

View full text Add to dashboard Cite

Diabetes mellitus has become one of the biggest medical challenges affecting millions of people globally. Alternative treatments for diabetes are currently being intensively investigated to improve the treatment efficacy and life qualities for diabetic patients. Glucose-responsive insulin release (GRIR) systems have exhibited tremendous potential to improve the normal glycemic control and to reduce the incidence of hyperglycemia and hypoglycemia, which further reduces potential complications in diabetic patients. In a given GRIR drug formulation, accuracy, response time, and reversibility of the GRIR functions are three key features enabling potential seamless control of blood glucose level. Nevertheless, there is significant challenge preventing current GRIR formulations from achieving them. This review article analyzes the most updated literature and provides insights on the impact of GRIR mechanisms, and formulations on these key features, and the relevant in vitro and in vivo evaluation methods to test these functions.

show abstract

Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery

Cited by 67 publications

References 34 publications

Polymeric hydrogels for oral insulin delivery

Polymeric hydrogels for oral insulin delivery

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Glucose-responsive insulin release: Analysis of mechanisms, formulations, and evaluation criteria

Contact Info

Product

Resources

About