Glucose-induced self-assembly and phase separation in hydrophilic triblock copolymers and the governing mechanism

Abstract

Poly(ethylene oxide, EO)-poly(propylene oxide, PO)–poly(ethylene oxide, EO) - based triblock copolymers (BCPs) with 80 % hydrophilicity stay molecularly dissolved as Gaussian chain at ambient temperature even at fairly high-concentrations (>...

Rationalizing the Design of Pluronics–Surfactant Mixed Micelles through Molecular Simulations and Experiments

“…The CP (which is often related to the dehydration of the PEO moiety with the progressive increase in temperature) of 1% w/v L81, i.e., ∼20 °C along with their CMT (<20 °C) is in accordance with the literature data. , The degree of hydrophobicity exhibited by the three cationic surfactants followed the order: DTAB < 12-2-12 < DDAB. ,,, Studies have also inferred that the clouding phenomenon in these conventional Pluronics can be impacted by the presence of additives, where both a deferral and an improvement were noticed. ,,− A small amount of an ionic surfactant drastically influences the CP of Pluronics. The temperature-dependent solution behavior for the examined Pluronics–cationic surfactants blended systems is presented in Figure .…”

Role of Unimers to Polymersomes Transition in Pluronic Blends for Controlled and Designated Drug Conveyance

“…A calibrated Cannon Ubbelohde viscometer was used to obtain η rel , and all measurements were performed in a water bath with temperature fluctuations maintained within ±0.2 °C. The flow rate of the solutions was determined using a calibrated stopwatch, and the procedure was repeated at least three times with a deviation of ±5 s. 7,15,43 Scattering Conduct. The hydrodynamic diameter (D h ) was determined using a dynamic light scattering (DLS) Zetasizer Nano device (Malvern Instruments, U.K.).…”

“…The curve was plotted for concentration vs normalized cell viability. 43,69 Cellular Uptake of Compounds. HeLa cells were trypsinized and seeded in 12 well plates on coverslips.…”

“…A calibrated Cannon Ubbelohde viscometer was used to obtain η rel , and all measurements were performed in a water bath with temperature fluctuations maintained within ±0.2 °C. The flow rate of the solutions was determined using a calibrated stopwatch, and the procedure was repeated at least three times with a deviation of ±5 s. ,, …”

Additive-anchored thermoresponsive nanoscale self-assembly generation in normal and reverse Tetronics®

“…19,20 Several researchers have placed a strong emphasis on the selective salts following the Hofmeister series in order to better comprehend the BCP micellar system under study and to draw clear comparisons with the salt-free aqueous system. 21,22 Sugars, and polyols, being biologically-active ingredients, are too widely used to trigger the micellization in Tetronics s . 9,22 Surfactants are frequently used in BCP solutions to alter their rheological characteristics and improve the stability of their dispersions and the CP as well.…”