1992
DOI: 10.1111/j.1471-4159.1992.tb09750.x
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Glucose, Insulin, and Insulin‐Like Growth Factor I Regulate the Glycogen Content of Astroglia‐Rich Primary Cultures

Abstract: The glycogen content of astroglia-rich primary cultures derived from the brains of newborn rats depends on the concentration of glucose in the culture medium. After administration of culture medium lacking glucose, the glycogen content decreases with a half-time of 7 min. Readdition of glucose results in replenishment of the glycogen stores within 2-3 h, but fully only if glucose is present in a concentration of at least 4 mM. Insulin, or the more potent insulin-like growth factor I, increases the content of g… Show more

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Cited by 135 publications
(115 citation statements)
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“…Membrane-In the present study, we show that insulin and IGF-1 affect the dynamics of glycogen stores in astrocytes by enhancing the accumulation of glycogen (57). The glycogen content in a cell depends on the intracellular levels of glucose, which in turn may also be dependent on the glucose transport across the plasma membrane via GLUTs.…”
Section: Insulin and Igf-1 Increase Glycogen Content In Astrocytes Insupporting
confidence: 49%
See 1 more Smart Citation
“…Membrane-In the present study, we show that insulin and IGF-1 affect the dynamics of glycogen stores in astrocytes by enhancing the accumulation of glycogen (57). The glycogen content in a cell depends on the intracellular levels of glucose, which in turn may also be dependent on the glucose transport across the plasma membrane via GLUTs.…”
Section: Insulin and Igf-1 Increase Glycogen Content In Astrocytes Insupporting
confidence: 49%
“…2 and 4). According to previous studies with radioisotopes, the maximum stimuli for forming glycogen is at 100 nM for insulin and 10 nM for IGF-1 (57). The maximum decrease in the cytosolic glucose concentration was 6% for insulin and 9% for IGF-1 after 300 s of stimulation.…”
Section: Insulin and Igf-1 Increase Glycogen Content In Astrocytes Inmentioning
confidence: 59%
“…For this set of nerves the control population incubated for 60 min in normal aCSF contained 4.85 Ϯ 0.31 pmol of glycogen/ g of protein (n ϭ 6). In other preparations exposure to high glucose concentration increases glycogen content (Prasannan and Subrahmanyam, 1966;Swanson et al, 1989b;Dringen and Hamprecht, 1992), whereas exposure to norepinephrine causes glycogen content to fall (Quach et al, 1978;Magistretti, 1988;Magistretti et al, 1993). Incubation of nerves in 25 mM glucose for 60 min induced an increase in glycogen stores to 7.90 Ϯ 0.59 pmol of glycogen/ g of protein (n ϭ 6; p Ͻ 0.001 vs control); conversely, pretreatment for 60 min with 1 mM norepinephrine led to a decline in RON glycogen (2.56 Ϯ 0.08 pmol of glycogen/ g of protein; n ϭ 7; p Ͻ 0.01 vs control).…”
Section: Glycogen Content Of Ronmentioning
confidence: 99%
“…Thus, glycogen was synthesized when glucose was abundant (Cummins et al, 1983) and degraded under glucose deprivation (Dringen and Hamprecht, 1992). This regulation is thought to result in a neuroprotective role for astrocytic glycogen under glucose deprivation, which was observed both in mixed cultures (Swanson and Choi, 1993) and the rat optic nerve (Wender et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Several studies suggested the involvement of brain glycogen in sleep cycle regulation (Kong et al, 2002;Petit et al, 2002). These changes in glycogen content may be brought about by a number of factors (Wiesinger et al, 1997) including hormones (Dringen and Hamprecht, 1992) and neurotransmitters (Hamai et al, 1999;Sorg and Magistretti, 1992;Swanson et al, 1990).…”
Section: Introductionmentioning
confidence: 99%