Glucose intolerance: is it a risk factor for cardiovascular disease in children with chronic kidney disease?

Canpolat, Nur; Çalışkan, Salim; Sever, Lale; Güzeltaş, Alper; Kantarcı, Fatih; Candan, Cengiz; Çivilibal, Mahmut; Kasapçopur, Özgür; Arısoy, Nı̇l

doi:10.1007/s00467-011-2034-3

Cited by 13 publications

(12 citation statements)

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“…Another finding was the association between serum hemoglobin and LVM, which is consistent with data from the literature that reports an association between anemia and LVMI 22,30. In a cross-sectional study evaluating 156 children undergoing dialysis with similar mean age to that of our study, an independent association between low serum hemoglobin and LVMI was reported 22.…”

Section: Discussionsupporting

confidence: 91%

Cardiovascular risk in children and adolescents with end stage renal disease

Val¹,

Menezes²,

Massaoka³

et al. 2019

Clinics

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OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD.

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Section: Discussionsupporting

confidence: 91%

Cardiovascular risk in children and adolescents with end stage renal disease

Val¹,

Menezes²,

Massaoka³

et al. 2019

Clinics

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“…IFG and IGT are common in pediatric CKD, including dialysis patients. Using the ADA definitions, 35% of pediatric non-dialysis CKD patients exhibit either IFG or IGT ( 35 ). While the prevalence for hyperinsulinemia varies between studies of pediatric CKD stage 2–4 (9–33%), insulin resistance reveals similar prevalence (16–19%) ( 36 ).…”

Section: Risk Factors and Risk Markersmentioning

confidence: 99%

Cardiovascular risks in chronic kidney disease pediatric patients (Review)

Tian

Niu

2017

Exp Ther Med

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One of the common factors for the premature death in children is advanced chronic kidney disease (CKD). Most often cardiovascular disease (CVD) is the reason for mortality. The cardiovascular (CV) morbidity starts early in the disease process and renal transplanted children (CKD-T) are also at risk. The present review is focused on the current views of the cardiovascular risks during CKD in pediatric patients. Variable data sources for the latest literature collection were explored which mainly included PubMed and Google Scholar. The most important risk factors for subclinical CVD were a young age, elevated BMI and systolic blood pressure z-scores as well as a low GFR and present albuminuria. Increasing blood pressure and BMI over follow-up were also important cardiac risk factors longitudinally. The present review concludes that altered cardiac function and remodeling are a concurrent part of the CKD process, start early in the disease development, and persist after renal transplantation. The findings suggest that children with CKD or CKD-T are at high risk for future CVD where younger patients with elevated BMI and slightly increased blood pressures, as well as present albuminuria, are those at greatest risk, thus indicating targets for future interventions.

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“…Disorder of the glucose and insulin metabolism in children with CKD on therapy with HD, and especially after kidney transplant is becoming more frequent 5 . Small studies on children with CKD, stage 2-4 or on HD, show that the prevalence of hyperinsulinemia is 33% and the prevalence of insulin resistance disorder is up to 16% (measured by homeostasis model assessment-estimated insulin resistance -HOMA IR) 33,34 . It appears that abnormalities in glucose and insulin metabolism are more prevalent than they were deemed to be.…”

Section: Disorders Of Glucose and Insulin Metabolismmentioning

confidence: 99%

“…It appears that abnormalities in glucose and insulin metabolism are more prevalent than they were deemed to be. Recent publications featuring studies on children after kidney transplantation have shown that the frequency of disorders of glucose and insulin metabolism is from 16% to 18% 33,35 .…”

Section: Disorders Of Glucose and Insulin Metabolismmentioning

confidence: 99%