Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro

Bos, Rémi; Vinay, Laurent

doi:10.1152/jn.00571.2011

Cited by 2 publications

(2 citation statements)

References 62 publications

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“…Bos and Vinay showed that in the neonatal rat lumbar spinal cord in vitro supplementing the ACSF with physiological concentrations of ESs does not alter the reversal potentials of synaptic currents mediated by GABA and glycine, known to be depolarizing at early developmental stages (Bos and Vinay, 2012) (Figure 1C). Moreover, ESs did not affect the depolarizing action of GABA on primary afferent terminals.…”

Section: The Role Of Energy Substrates In Gaba Polaritymentioning

confidence: 99%

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Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

Ben-Ari¹,

Woodin²,

Sernagor³

et al. 2012

Front. Cell. Neurosci.

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During brain development, there is a progressive reduction of intracellular chloride associated with a shift in GABA polarity: GABA depolarizes and occasionally excites immature neurons, subsequently hyperpolarizing them at later stages of development. This sequence, which has been observed in a wide range of animal species, brain structures and preparations, is thought to play an important role in activity-dependent formation and modulation of functional circuits. This sequence has also been considerably reinforced recently with new data pointing to an evolutionary preserved rule. In a recent “Hypothesis and Theory Article,” the excitatory action of GABA in early brain development is suggested to be “an experimental artefact” (Bregestovski and Bernard, 2012). The authors suggest that the excitatory action of GABA is due to an inadequate/insufficient energy supply in glucose-perfused slices and/or to the damage produced by the slicing procedure. However, these observations have been repeatedly contradicted by many groups and are inconsistent with a large body of evidence including the fact that the developmental shift is neither restricted to slices nor to rodents. We summarize the overwhelming evidence in support of both excitatory GABA during development, and the implications this has in developmental neurobiology.

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Section: The Role Of Energy Substrates In Gaba Polaritymentioning

confidence: 99%

“…Right panel demonstrates the amplitude of IPSPs as a function of holding potential in both control and DL-BHB conditions, respectively. [Modified from Bos and Vinay (2012)]. (D) Energy substrates (DL-BHB, 4 mM) do not affect GABA-mediated depolarization in cultured hippocampal neurons.…”

Section: The Role Of Energy Substrates In Gaba Polaritymentioning

confidence: 99%

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

Ben-Ari¹,

Woodin²,

Sernagor³

et al. 2012

Front. Cell. Neurosci.

Self Cite

140

125

View full text Add to dashboard Cite

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Development of coherent neuronal activity patterns in mammalian cortical networks: Common principles and local hetereogeneity

Egorov

Draguhn

2013

Mechanisms of Development

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Many mammals are born in a very immature state and develop their rich repertoire of behavioral and cognitive functions postnatally. This development goes in parallel with changes in the anatomical and functional organization of cortical structures which are involved in most complex activities. The emerging spatiotemporal activity patterns in multi-neuronal cortical networks may indeed form a direct neuronal correlate of systemic functions like perception, sensorimotor integration, decision making or memory formation. During recent years, several studies--mostly in rodents--have shed light on the ontogenesis of such highly organized patterns of network activity. While each local network has its own peculiar properties, some general rules can be derived. We therefore review and compare data from the developing hippocampus, neocortex and--as an intermediate region--entorhinal cortex. All cortices seem to follow a characteristic sequence starting with uncorrelated activity in uncoupled single neurons where transient activity seems to have mostly trophic effects. In rodents, before and shortly after birth, cortical networks develop weakly coordinated multineuronal discharges which have been termed synchronous plateau assemblies (SPAs). While these patterns rely mostly on electrical coupling by gap junctions, the subsequent increase in number and maturation of chemical synapses leads to the generation of large-scale coherent discharges. These patterns have been termed giant depolarizing potentials (GDPs) for predominantly GABA-induced events or early network oscillations (ENOs) for mostly glutamatergic bursts, respectively. During the third to fourth postnatal week, cortical areas reach their final activity patterns with distinct network oscillations and highly specific neuronal discharge sequences which support adult behavior. While some of the mechanisms underlying maturation of network activity have been elucidated much work remains to be done in order to fully understand the rules governing transition from immature to mature patterns of network activity.

show abstract

Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro

Cited by 2 publications

References 62 publications

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

Development of coherent neuronal activity patterns in mammalian cortical networks: Common principles and local hetereogeneity

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