Glucose Lowering Activity of Aqueous Ammodaucus leucotrichus Extract in Diabetic Rats

Abstract

Background: Ammodaucus leucotrichus (Apiaceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Aims: The aim of this study was to evaluate the antidiabetic effect of the aqueous extract prepared from the fruits of this medicinal plant. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of Ammodaucus leucotrichus (A. leucotrichus) at a dose of 10 mg/kg. Methods: The blood glucose levels were determined during 6 hours and 15 days during this treatment. In addition the oral glucose tolerance test as well as the analysis of histopathological changes of liver was performed. The antioxidant activity of aqueous A. Leucotrichus extract was also valuated by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH). Results: A. Leucotrichus fruit aqueous extract (ALFAE) reduced the blood glucose levels in both normal and diabetic rats. In addition, a remarkable influence on glucose tolerance was also noticed after ALFAE treatment. Moreover, ALFAE was able to exhibit a beneficial effect on histologlogical structure of liver. Finally a potential antioxidant effect has been shown in vitro. Conclusion: In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of A. Leucotrichus in rats supporting then its traditional use for the management of diabetes.

Medicinal uses, phytochemistry and pharmacology of Ammodaucus leucotrichus

“…Blood glucose was significantly reduced after 15 days of oral administration of the plant extract at a dose of 10 mg/kg. In addition, Ammodaucus leucotrichus fruit aqueous extract was able to exhibit a beneficial effect on histologlogical structure of liver and a remarkable influence on glucose tolerance [26].…”

“…Required concentrations to neutralize and stabilize 50% of DPPH concentration goes from 2 to 4 μg/ml [5]. A potential antioxidant effect of the aqueous extract from the fruits of Ammodaucus leucotrichus has been shown, in vitro, by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl [26].…”

“…El-Ouady et al [26] evaluated anti-diabetic activities of aqueous extract of Ammodaucus leucotrichus fruits in streptozotocin-induced diabetic rats. Blood glucose was significantly reduced after 15 days of oral administration of the plant extract at a dose of 10 mg/kg.…”

Ethnopharmacological Documentation of Medicinal Plants Used in the Traditional Treatment of Hypertension in Tarfaya Province, Morocco

“…Analysis of the data obtained showed that the age of the respondents varied between 22 and 80 years, with a majority of the age group [41][42][43][44][45][46][47][48][49][50] at 34%. Then come the age groups [51][52][53][54][55][56][57][58][59][60], [31][32][33][34][35][36][37][38][39][40], [21][22][23][24][25][26][27][28][29][30] and finally those over 61, with a rate of 26%, 18.7%, 11.3% and 10% respectively.…”

Ammodaucus leucotrichus Coss. & Durieu: Antihyperglycemic activity via the inhibition of α-amylase, α-glucosidase, and intestinal glucose absorption activities and its chemical composition

“…The leaves and seeds are used in the form of decoction or infusion for several therapeutic cases, such as blood pressure, chest pain, liver and digestive system ailments, gastroenteritis, as also for diabetes (Ziani et al, 2019). Furthermore, a pharmacological study realized showed that A. leucotrichus fruits had a significant effect on diabetes (El-Ouady and Eddouks, 2019). Currently, no study has been carried out on its action mechanisms.…”