Glucose-lowering properties of vanadium compounds: Comparison of coordination complexes with maltol or kojic acid as ligands

Yuen, Violet G.; Caravan, Peter; Gelmini, Lucio; Glover, Nicholas R.; McNeill, John H.; Setyawati, Ika A.; Zhou, Ying; Orvig, Chris

doi:10.1016/s0162-0134(97)00082-2

Cited by 103 publications

(71 citation statements)

References 34 publications

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“…Among the biomolecules present in intra and extra-cellular fluids, proteins have a special importance because of their high amount in the cellular environment and their possible interaction with metal ions through a number of active sites. Several oxovanadium(IV) complexes with various coordination modes [7] and the relationship between their structures and insulin-mimetic activities has been already examined by several research groups [8] evaluating both in vivo and in vitro results.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine

Patel¹,

Singh²,

Patel³

et al. 2018

Asian J. Chem.

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, 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (dimphen), 2,2′-bipyridyl (bpy) and 2-(2-pyridyl)benimidazole (bipybenImH)], have been synthesized and characterized by elemental analysis, UV-visible spectroscopy, Fourier transform IR spectroscopy, EPR spectroscopy, cyclic voltammetric and differential pulse voltammetric techniques. The oxidation state of V(IV) with d 1 configuration was confirmed by EPR spectroscopy. The complexes were also tested for in vitro antidiabetic activity. Moderate α-glucosidase inhibitions are shown by these complexes. This suggested that the complexes may be promising candidates as antidiabetic agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine

Patel¹,

Singh²,

Patel³

et al. 2018

Asian J. Chem.

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“…[8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization.…”

Section: Introductionmentioning

confidence: 99%

“…7 Bis(maltolate) metal(IV) complexes are extensively used in medical studies to assess their therapeutic value as active agents against diabetes, as agents for controlling metal levels in the body and as contrast agents in imaging applications. [8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization.…”

Section: Introductionmentioning

confidence: 99%

A New Post-Metallocene-Ti Catalyst with Maltolate Bidentade Ligand: an Investigation in Heterogeneous Polymerization Reactions in Different Mesoporous Supports

Gheno¹,

Basso²,

Livotto³

et al. 2016

Journal of the Brazilian Chemical Society

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A new titanium catalyst easily synthesized from ethylmaltol bidentate chelator ligand was studied in homogeneous and heterogeneous ethylene polymerization. The dichlorobis(3-hydroxy-2-ethyl-4-pyrone)titanium(IV) complex was characterized by 1 H and 13 C NMR (nuclear magnetic resonance), UV-Vis and elemental analysis. Theoretical study by density functional theory (DFT) showed that the complex chlorines exhibit cis configuration, which is important for the activity in olefin polymerization. The complex was supported by two methods, direct impregnation or methylaluminoxane (MAO) pre-treatment, in five mesoporous supports: MCM-41 (micro and nano), SBA-15 and also the corresponding modified Al species. All the catalytic systems were active in ethylene polymerization and the catalytic activity was strongly influenced by the method of immobilization of the catalyst and the type of support. Keywords: catalysis, synthesis, mesoporous support, immobilization, polyethylene IntroductionPolyethylene (PE) has a broad application in different segments of the everyday life, from food packaging to resistant pieces for engineering. Due to the polymer industrial demands, continuous development of new technologies and synthetic methods for obtaining this material are necessary. Existing processes, involving polyethylene synthesis in industrial and/or research scale, use Ziegler-Natta, metallocene, and more recently, postmetallocene catalysts. Our research group has studied the synthesis of different post-metallocene catalysts and tested these complexes in ethylene polymerization. Organometallic complexes of Ti and Zr were obtained from bidentate chelator ligands as naphthoquinone, methylpyrone, ethylpyrone and 3-hydroxyflavone. [1][2][3][4][5] All the synthesized complexes were active in homogeneous ethylene polymerization at different reaction conditions. 3-Hydroxy-2-methyl-4-pyrone (methylpyrone or maltol) is a non-toxic compound of natural occurrence in many plants, 6 while 3-hydroxy-2-ethyl-4-pyrone (ethylmaltol) is a synthetic commercial product. These organic compounds are commonly used in food industries as flavor ingredients. Both hydroxypyrones are characterized by their synthetic versatility and they easily coordinate with transition metals of group IV to give L 2 MCl 2 complexes.7 Bis(maltolate) metal(IV) complexes are extensively used in medical studies to assess their therapeutic value as active agents against diabetes, as agents for controlling metal levels in the body and as contrast agents in imaging applications. [8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al. 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization. Subsequently, our research group has synthesized several Ti and Zr complexes Gheno et al. 2083 Vol. 27, No. 11, 2016 analogous based in maltolate ligands. The synthesized complexes were shown to be active in the ethylene...

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“…This fact is explained by the possible applications of maltol to control the level of metals content in an organism, either by excretion of their excess in the form of metal chelates, through coordination with maltol in the organism, [6][7][8] or by transportation of necessary metals as chelate complexes to the organism with therapeutic 9,10 and diagnostic purposes. [11][12][13] Inorganic compounds of bismuth (trioxide, nitrate) or bismuth acetate are usually used for the treatment of various gastrointestinal diseases as well as the preparation of antiseptic and woundhealing products. 14,15 But these drugs possess various side-effects (bismuth stomatitis, dermatitis, nephropathy) related to their toxicity and slow and incomplete excretion from organism.…”

Section: Introductionmentioning

confidence: 99%

Stereoactive lone pair of electrons on bismuth(III): tris(3-hydroxy- 2-methyl-4H-pyran-4-onato)bismuth(III)

Сухов¹,

Mukha²,

Antipova³

et al. 2008

Arkivoc

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Glucose-lowering properties of vanadium compounds: Comparison of coordination complexes with maltol or kojic acid as ligands

Cited by 103 publications

References 34 publications

Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine

Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine

A New Post-Metallocene-Ti Catalyst with Maltolate Bidentade Ligand: an Investigation in Heterogeneous Polymerization Reactions in Different Mesoporous Supports

Stereoactive lone pair of electrons on bismuth(III): tris(3-hydroxy- 2-methyl-4H-pyran-4-onato)bismuth(III)

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