Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression

Abstract

Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor prognosis are unresolved issues of PC. The concept of metabolic reprogramming is a hallmark of cancer cells. Increasing evidence shows that PC cells alter metabolic processes such as glucose, amino acids, and lipids metabolism and require continuous nutrition for survival, proliferation, and invasion. Glucose metabolism, in particular, regulates the tumour microenvironment (TME). Furthermore, the link between glucose metabolism and TME also plays an important role in the targeted therapy, chemoresistance, radiotherapy ineffectiveness, and immunosuppression of PC. Altered metabolism with the TME has emerged as a key mechanism regulating PC progression. This review shed light on the relationship between TME, glucose metabolism, and various aspects of PC. The findings of this study provide a new direction in the development of PC therapy targeting the metabolism of cancer cells.

GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy

“…The bioenergetic and biosynthetic processes in tumor cells necessitate reprogrammed metabolic behaviors, which are susceptible to interference from genetic mutations, contributing to the evasion of metabolic monitoring and uncontrolled proliferation [19][20][21]. Studies have abundantly demonstrated the profound impact of glucose metabolism on the pathogenesis and progression of tumors [22]. In the spectrum of glucose metabolism processes, tumor cells predominantly utilize aerobic glycolysis to generate ample adenosine triphosphate (ATP) [23,24].…”

Metadichol-Induced Differentiation of Pancreatic Ductal Cells (PANC-1) into Insulin-Producing Cells

“…6,7,8 Sirtuin 1, a transcription factor Glucose metabolism regulation and insulin sensitivity However, reprogramming pancreatic cancer cells presents many challenges; [9][10][11] . Dong 12 explored the potential for reprogramming the tumor microenvironment in pancreatic cancer, including endocrine gene expression, to improve glucose metabolism and decrease tumor growth. 13 .…”